Page last updated: 2024-10-31

mirtazapine and Neuralgia

mirtazapine has been researched along with Neuralgia in 6 studies

Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.

Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Research Excerpts

ExcerptRelevanceReference
" The present study was designed to explore the effects and most appropriate dosage of mirtazapine in treating neuropathic pain and its possible neuroimmune mechanisms."5.35Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain. ( Feng, X; Hu, Y; Song, J; Wei, X; Xu, J; Zhu, J, 2008)
"Mirtazapine (MTZ) is a new and well-tolerated tricyclic antidepressants with both monoaminergic and opioid properties that might favorably influence pain."2.73Mirtazapine decreases the pain feeling in healthy participants. ( Arnold, P; Deriaz, O; Gobelet, C; Kuntzer, T; Vuadens, P, 2008)
" Time-course data for the dose-response effects were analyzed using two-way analysis of variance and the posthoc Tukey-Kramer multiple-comparison test."1.40Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. ( Hashimoto, R; Hosokawa, K; Mashimo, T; Nakae, A; Nakai, K, 2014)
"Mirtazapine (MTZ) is an antidepressant, which is considered to enhance noradrenergic and serotonergic neurotransmission via antagonistic action at central α2-adrenergic autoreceptors and heteroreceptors."1.38Effects of mirtazapine on sleep disturbance under neuropathic pain-like state. ( Enomoto, T; Hirayama, S; Horiuchi, H; Ikegami, D; Inada, E; Iseki, M; Nagase, H; Nakahara, K; Narita, M; Sakai, H; Suzuki, T; Torigoe, K; Yamashita, A; Yanase, M, 2012)
" All substances were dosed between 0."1.35Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats. ( Driehsen, C; Freynhagen, R; Hermanns, H; Lipfert, P; Muth-Selbach, U, 2009)
" The present study was designed to explore the effects and most appropriate dosage of mirtazapine in treating neuropathic pain and its possible neuroimmune mechanisms."1.35Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain. ( Feng, X; Hu, Y; Song, J; Wei, X; Xu, J; Zhu, J, 2008)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nakai, K1
Nakae, A1
Hashimoto, R1
Mashimo, T1
Hosokawa, K1
Muth-Selbach, U1
Hermanns, H1
Driehsen, C1
Lipfert, P1
Freynhagen, R1
Enomoto, T1
Yamashita, A1
Torigoe, K1
Horiuchi, H1
Hirayama, S1
Nakahara, K1
Yanase, M1
Sakai, H1
Ikegami, D1
Nagase, H1
Suzuki, T1
Iseki, M1
Inada, E1
Narita, M1
Masuzawa, M1
Taguchi, H1
Sugimoto, T1
Kojima, H1
Matsumoto, S1
Kojima, K1
Shingu, K1
Arnold, P1
Vuadens, P1
Kuntzer, T1
Gobelet, C1
Deriaz, O1
Zhu, J1
Wei, X1
Feng, X1
Song, J1
Hu, Y1
Xu, J1

Trials

1 trial available for mirtazapine and Neuralgia

ArticleYear
Mirtazapine decreases the pain feeling in healthy participants.
    The Clinical journal of pain, 2008, Volume: 24, Issue:2

    Topics: Adult; Analgesics; Antidepressive Agents, Tricyclic; Cross-Over Studies; Double-Blind Method; Drug A

2008

Other Studies

5 other studies available for mirtazapine and Neuralgia

ArticleYear
Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats.
    Journal of oral & facial pain and headache, 2014,Winter, Volume: 28, Issue:1

    Topics: Adrenergic alpha-Antagonists; Amines; Analgesics; Animals; Cranial Nerve Injuries; Cyclohexanecarbox

2014
Racemic intrathecal mirtazapine but not its enantiomers acts anti-neuropathic after chronic constriction injury in rats.
    Brain research bulletin, 2009, Apr-06, Volume: 79, Issue:1

    Topics: Analgesics; Animals; Antidepressive Agents; Hot Temperature; Hyperalgesia; Injections, Spinal; Male;

2009
Effects of mirtazapine on sleep disturbance under neuropathic pain-like state.
    Synapse (New York, N.Y.), 2012, Volume: 66, Issue:6

    Topics: Animals; Disease Models, Animal; Histamine H1 Antagonists; Hyperalgesia; Male; Mianserin; Mice; Mice

2012
[Case of successful management with mirtazapine for prolonged pain after esophagectomy].
    Masui. The Japanese journal of anesthesiology, 2012, Volume: 61, Issue:9

    Topics: Adrenergic alpha-Antagonists; Antidepressive Agents, Tricyclic; Esophageal Neoplasms; Esophagectomy;

2012
Repeated administration of mirtazapine inhibits development of hyperalgesia/allodynia and activation of NF-kappaB in a rat model of neuropathic pain.
    Neuroscience letters, 2008, Mar-05, Volume: 433, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Cytokines; Denervation; Disease Models, Animal; Do

2008