Page last updated: 2024-10-31

mirtazapine and Neoplasms

mirtazapine has been researched along with Neoplasms in 27 studies

Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"This study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia."9.41Mirtazapine in Cancer-Associated Anorexia and Cachexia: A Double-Blind Placebo-Controlled Randomized Trial. ( Abdel-Aal, HH; Alsirafy, SA; Elsherief, WA; Farag, DE; Hunter, CN; Riad, NM, 2021)
"We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)."9.14Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010)
"The purpose of the present paper was to evaluate the effectiveness of mirtazapine orally disintegrating tablets for nausea and sleep disturbance, which are common and distressing symptoms of cancer."9.13Effectiveness of mirtazapine for nausea and insomnia in cancer patients with depression. ( Kim, JM; Kim, KM; Kim, KS; Kim, SW; Kim, YC; Shin, IS; Yang, SJ; Yoon, JS, 2008)
"We conducted a nested case-control study to evaluate the association between risk of cancer and mirtazapine use in depression patients in Taiwan."7.79Does use of tetracyclic antidepressant-mirtazapine reduce cancer risk in depression patients? ( Chang, SN; Chang, YJ; Kao, CH; Liang, JA; Lin, MC; Muo, CH; Sun, LM; Sung, FC, 2013)
"Mirtazapine and olanzapine are easy-to-use psychiatric drugs with potent antinausea effects."7.74Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. ( Foley, KF; Kast, RE, 2007)
"Mirtazapine is a noradrenergic and specific serotonergic antidepressant(NaSSA)."6.74[Efficacy of mirtazapine for appetite loss and nausea of the cancer patient--from clinical experience in Memorial Sloan-Kettering Cancer Center]. ( Ito, T; Okubo, Y; Roth, A, 2009)
"This study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia."5.41Mirtazapine in Cancer-Associated Anorexia and Cachexia: A Double-Blind Placebo-Controlled Randomized Trial. ( Abdel-Aal, HH; Alsirafy, SA; Elsherief, WA; Farag, DE; Hunter, CN; Riad, NM, 2021)
"Pruritus is a relatively rare but distressing symptom associated with cholestasis, renal failure, and malignancies."5.32Mirtazapine for pruritus. ( Andresen, S; Davis, MP; Frandsen, JL; Taylor, S; Walsh, D, 2003)
"We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)."5.14Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010)
"The purpose of the present paper was to evaluate the effectiveness of mirtazapine orally disintegrating tablets for nausea and sleep disturbance, which are common and distressing symptoms of cancer."5.13Effectiveness of mirtazapine for nausea and insomnia in cancer patients with depression. ( Kim, JM; Kim, KM; Kim, KS; Kim, SW; Kim, YC; Shin, IS; Yang, SJ; Yoon, JS, 2008)
"This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms."5.13Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine. ( Akbiyik, DI; Alkis, N; Cankurtaran, ES; Ozalp, E; Soygur, H; Turhan, L, 2008)
"We conducted a nested case-control study to evaluate the association between risk of cancer and mirtazapine use in depression patients in Taiwan."3.79Does use of tetracyclic antidepressant-mirtazapine reduce cancer risk in depression patients? ( Chang, SN; Chang, YJ; Kao, CH; Liang, JA; Lin, MC; Muo, CH; Sun, LM; Sung, FC, 2013)
"Mirtazapine and olanzapine are easy-to-use psychiatric drugs with potent antinausea effects."3.74Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. ( Foley, KF; Kast, RE, 2007)
" This might lead to polypharmacy and increase adverse events representing major threats to the quality of health care, especially in palliative care situations."3.11What is the effectiveness and safety of mirtazapine versus escitalopram in alleviating cancer-associated poly-symptomatology (the MIR-P study)? A mixed-method randomized controlled trial protocol. ( Alexandre, M; Economos, G; Glehen, O; Haesebaert, J; Perceau-Chambard, E; Subtil, F; Villeneuve, L, 2022)
"It involved 88 terminally ill cancer patients from University of Malaya Medical Centre, Kuala Lumpur, Malaysia."2.79Rapid response to methylphenidate as an add-on therapy to mirtazapine in the treatment of major depressive disorder in terminally ill cancer patients: a four-week, randomized, double-blinded, placebo-controlled study. ( Boks, MP; de Wit, NJ; Ng, CG; Roes, KC; Sulaiman, AH; Tan, SB; Zainal, NZ, 2014)
"Mirtazapine is a noradrenergic and specific serotonergic antidepressant(NaSSA)."2.74[Efficacy of mirtazapine for appetite loss and nausea of the cancer patient--from clinical experience in Memorial Sloan-Kettering Cancer Center]. ( Ito, T; Okubo, Y; Roth, A, 2009)
"Depression is quite common among cancer patients."2.73An open-label long-term naturalistic study of mirtazapine treatment for depression in cancer patients. ( Elbi, H; Ersoy, MA; Noyan, AM, 2008)
"Anorexia is the common symptom of malnutrition in cancer patients."2.72Appetite problem in cancer patients: Pathophysiology, diagnosis, and treatment. ( Hariyanto, TI; Kurniawan, A, 2021)
"In cases of malignancy that are refractive to treatment, other therapies have been found to be effective for paraneoplastic itch, including selective serotonin reuptake inhibitors, mirtazapine, gabapentin, thalidomide, opioids, aprepitant, and histone deacetylase inhibitors."2.53Paraneoplastic Itch Management. ( Rowe, B; Yosipovitch, G, 2016)
"Advanced cancer patients are polysymptomatic and often receive multiple medications for symptom relief."2.41Management of symptoms associated with advanced cancer: olanzapine and mirtazapine. A World Health Organization project. ( Davis, MP; Khawam, E; Lagman, R; Pozuelo, L, 2002)
" Adverse events were commonly seen in the oncology population."1.72Propensity score-matching analysis comparing safety outcomes of appetite-stimulating medications in oncology patients. ( Burger, A; Eladghm, N; Gamaleldin, A; Marie Gavioli, E; Vider, E, 2022)
"Mirtazapine was administered to 50 cancer patients with digestive symptoms in palliative care, and the data were retrospectively examined."1.40[Effectiveness of mirtazapine for digestive symptoms in palliative care - retrospective study of 50 cases]. ( Imai, E; Nishimura, D; Shibahara, H; Tokura, Y; Uematsu, N, 2014)
"One hundred sixty-five patients with cancer, consecutively admitted to the Oncology Division of San Camillo-Forlanini Hospital, were recruited to the study."1.33Detection and treatment of depressive and anxiety disorders among cancer patients: feasibility and preliminary findings from a liaison service in an oncology division. ( Biondi, M; Cairoli, F; Costantini, A; Ferrarese, G; Pasquini, M; Picardi, A; Sternberg, C, 2006)
"Pruritus is a relatively rare but distressing symptom associated with cholestasis, renal failure, and malignancies."1.32Mirtazapine for pruritus. ( Andresen, S; Davis, MP; Frandsen, JL; Taylor, S; Walsh, D, 2003)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (44.44)29.6817
2010's8 (29.63)24.3611
2020's7 (25.93)2.80

Authors

AuthorsStudies
Lavan, O1
Peled, O1
Avishai-Neumann, M1
Weizman, A1
Yahel, A1
Apter, A1
Valevski, A1
Fennig, S1
Stein, J1
Benaroya-Milshtein, N1
Marie Gavioli, E1
Burger, A1
Gamaleldin, A1
Eladghm, N1
Vider, E1
Economos, G2
Alexandre, M1
Perceau-Chambard, E1
Villeneuve, L1
Subtil, F1
Haesebaert, J1
Glehen, O1
Vita, G1
Compri, B1
Matcham, F1
Barbui, C1
Ostuzzi, G1
Lovell, N1
Johnston, A1
Higginson, IJ1
Hariyanto, TI1
Kurniawan, A1
Hunter, CN1
Abdel-Aal, HH1
Elsherief, WA1
Farag, DE1
Riad, NM1
Alsirafy, SA1
Sun, LM1
Lin, MC1
Liang, JA1
Chang, YJ1
Chang, SN1
Sung, FC1
Muo, CH1
Kao, CH1
Raddin, RS1
Park, EM1
Hamer, RM1
Nelson, KM1
Mayer, DK1
Rosenstein, DL1
Bernard, SA1
Ng, CG1
Boks, MP1
Roes, KC1
Zainal, NZ1
Sulaiman, AH1
Tan, SB1
de Wit, NJ1
Shibahara, H1
Uematsu, N1
Imai, E1
Tokura, Y1
Nishimura, D1
Uzawa, K1
Kasamatsu, A1
Shimizu, T1
Saito, Y1
Baba, T1
Sakuma, K1
Fushimi, K1
Sakamoto, Y1
Ogawara, K1
Shiiba, M1
Tanzawa, H1
Rowe, B1
Yosipovitch, G1
Ito, T1
Okubo, Y1
Roth, A1
Riechelmann, RP1
Burman, D1
Tannock, IF1
Rodin, G1
Zimmermann, C1
Davis, MP3
Kirkova, J1
Lagman, R2
Walsh, D2
Karafa, M1
Van Gool, AR1
Bannink, M1
Stronks, DL1
Vos, MS1
Frandsen, JL1
Andresen, S1
Taylor, S1
Khawam, E1
Pozuelo, L1
Raji, MA2
Pasquini, M1
Biondi, M1
Costantini, A1
Cairoli, F1
Ferrarese, G1
Picardi, A1
Sternberg, C1
Kast, RE1
Foley, KF1
Barnum, PD1
Freeman, J1
Markowitz, AB1
Ersoy, MA1
Noyan, AM1
Elbi, H1
Kim, SW1
Shin, IS1
Kim, JM1
Kim, YC1
Kim, KS1
Kim, KM1
Yang, SJ1
Yoon, JS1
Cankurtaran, ES1
Ozalp, E1
Soygur, H1
Akbiyik, DI1
Turhan, L1
Alkis, N1
Theobald, DE1
Kirsh, KL1
Holtsclaw, E1
Donaghy, K1
Passik, SD1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
What is the Effectiveness and Safety of Mirtazapine Versus Escitalopram in Alleviating Cancer-associated Poly-symptomatology (MIR-P)? A Mixed-method Randomized Controlled Trial Protocol[NCT04763135]Phase 31 participants (Actual)Interventional2021-12-15Terminated (stopped due to difficulties in recruiting)
A Parallel-group, Double-blind, Placebo-controlled Study of Methylphenidate as an Add on Therapy for Mirtazapine in the Treatment of Major Depressive Disorder in Cancer Patients Under Palliative Care[NCT01497548]Phase 3120 participants (Anticipated)Interventional2011-03-31Recruiting
Efficacy and Safety Analyses of Mirtazapine in the Treatment of Malignant Tumor Related Depression: A Phase II, Placebo-controlled, Randomized, Double-blinded Clinical Trial in Advanced Non-small Cell Lung Cancer Patients[NCT02650544]Phase 2236 participants (Anticipated)Interventional2015-12-31Active, not recruiting
Randomized, Double-blind Clinical Trial of the Use of Mirtazapine Versus Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.[NCT03283488]Phase 252 participants (Actual)Interventional2019-03-26Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for mirtazapine and Neoplasms

ArticleYear
Psychopharmacology in the Pediatric Oncology and Bone Marrow Transplant Units: Antidepressant Treatment.
    Journal of child and adolescent psychopharmacology, 2022, Volume: 32, Issue:3

    Topics: Adolescent; Antidepressive Agents; Child; Depressive Disorder, Major; Humans; Mirtazapine; Neoplasms

2022
Antidepressants for the treatment of depression in people with cancer.
    The Cochrane database of systematic reviews, 2023, 03-31, Volume: 3

    Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Depression; Depressive Disorder, Maj

2023
What is the evidence for mirtazapine in treating cancer-related symptomatology? A systematic review.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020, Volume: 28, Issue:4

    Topics: Adrenergic alpha-2 Receptor Antagonists; Antidepressive Agents; Clinical Trials as Topic; Depression

2020
Appetite problem in cancer patients: Pathophysiology, diagnosis, and treatment.
    Cancer treatment and research communications, 2021, Volume: 27

    Topics: Anorexia; Appetite; Clinical Trials, Phase III as Topic; Eicosapentaenoic Acid; Growth Differentiati

2021
Paraneoplastic Itch Management.
    Current problems in dermatology, 2016, Volume: 50

    Topics: Acantholysis; Acanthosis Nigricans; Analgesics, Opioid; Anticonvulsants; Antidepressive Agents; Apre

2016
Management of symptoms associated with advanced cancer: olanzapine and mirtazapine. A World Health Organization project.
    Expert review of anticancer therapy, 2002, Volume: 2, Issue:4

    Topics: Antidepressive Agents; Antipsychotic Agents; Benzodiazepines; Drug Interactions; Humans; Mianserin;

2002

Trials

9 trials available for mirtazapine and Neoplasms

ArticleYear
What is the effectiveness and safety of mirtazapine versus escitalopram in alleviating cancer-associated poly-symptomatology (the MIR-P study)? A mixed-method randomized controlled trial protocol.
    BMC palliative care, 2022, May-23, Volume: 21, Issue:1

    Topics: Antidepressive Agents; Depressive Disorder, Major; Escitalopram; Humans; Mirtazapine; Neoplasms; Pro

2022
Mirtazapine in Cancer-Associated Anorexia and Cachexia: A Double-Blind Placebo-Controlled Randomized Trial.
    Journal of pain and symptom management, 2021, Volume: 62, Issue:6

    Topics: Anorexia; Cachexia; Double-Blind Method; Hand Strength; Humans; Mirtazapine; Neoplasms

2021
Rapid response to methylphenidate as an add-on therapy to mirtazapine in the treatment of major depressive disorder in terminally ill cancer patients: a four-week, randomized, double-blinded, placebo-controlled study.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2014, Volume: 24, Issue:4

    Topics: Academic Medical Centers; Aged; Antidepressive Agents; Depressive Disorder, Major; Diagnostic and St

2014
[Efficacy of mirtazapine for appetite loss and nausea of the cancer patient--from clinical experience in Memorial Sloan-Kettering Cancer Center].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2009, Volume: 36, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Appetite; Appetite Stimulants; Female; Hospit

2009
Phase II trial of mirtazapine for cancer-related cachexia and anorexia.
    The American journal of hospice & palliative care, 2010, Volume: 27, Issue:2

    Topics: Aged; Aged, 80 and over; Anorexia; Antidepressive Agents, Tricyclic; Appetite; Body Weight; Cachexia

2010
An open-label long-term naturalistic study of mirtazapine treatment for depression in cancer patients.
    Clinical drug investigation, 2008, Volume: 28, Issue:2

    Topics: Administration, Oral; Adult; Aged; Anorexia; Antidepressive Agents, Tricyclic; Depressive Disorder;

2008
Effectiveness of mirtazapine for nausea and insomnia in cancer patients with depression.
    Psychiatry and clinical neurosciences, 2008, Volume: 62, Issue:1

    Topics: Adjustment Disorders; Administration, Oral; Adult; Aged; Antidepressive Agents, Tricyclic; Depressiv

2008
Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2008, Volume: 16, Issue:11

    Topics: Adaptation, Psychological; Adjustment Disorders; Adrenergic alpha-Antagonists; Adult; Antidepressive

2008
An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Cross-Over Studies; Depression; Dose-Response Relationship, Drug;

2002
An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Cross-Over Studies; Depression; Dose-Response Relationship, Drug;

2002
An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Cross-Over Studies; Depression; Dose-Response Relationship, Drug;

2002
An open-label, crossover trial of mirtazapine (15 and 30 mg) in cancer patients with pain and other distressing symptoms.
    Journal of pain and symptom management, 2002, Volume: 23, Issue:5

    Topics: Antidepressive Agents, Tricyclic; Cross-Over Studies; Depression; Dose-Response Relationship, Drug;

2002

Other Studies

12 other studies available for mirtazapine and Neoplasms

ArticleYear
Propensity score-matching analysis comparing safety outcomes of appetite-stimulating medications in oncology patients.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022, Volume: 30, Issue:7

    Topics: Adult; Aged; Anorexia; Appetite; Appetite Stimulants; Cachexia; Hallucinations; Humans; Long QT Synd

2022
Does use of tetracyclic antidepressant-mirtazapine reduce cancer risk in depression patients?
    Pharmacoepidemiology and drug safety, 2013, Volume: 22, Issue:12

    Topics: Adult; Age Factors; Aged; Antidepressive Agents; Case-Control Studies; Chi-Square Distribution; Como

2013
A pilot study to evaluate symptom-oriented selection of antidepressants in patients with cancer.
    Journal of palliative medicine, 2014, Volume: 17, Issue:2

    Topics: Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Depressive D

2014
[Effectiveness of mirtazapine for digestive symptoms in palliative care - retrospective study of 50 cases].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2014, Volume: 41, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Feeding and Eating Disorders; Female; Humans; Male; Mianserin; Middl

2014
Suppression of metastasis by mirtazapine via restoration of the Lin-7C/β-catenin pathway in human cancer cells.
    Scientific reports, 2014, Jun-25, Volume: 4

    Topics: Adrenergic alpha-Antagonists; Animals; beta Catenin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cel

2014
Intolerance to mirtazapine in advanced cancer.
    Journal of pain and symptom management, 2011, Volume: 42, Issue:3

    Topics: Aged; Antidepressive Agents; Depressive Disorder; Disorders of Excessive Somnolence; Female; Humans;

2011
Re: Mirtazapine in cancer patients.
    Journal of pain and symptom management, 2003, Volume: 25, Issue:1

    Topics: Antidepressive Agents, Tricyclic; Depression; Female; Humans; Male; Mianserin; Middle Aged; Mirtazap

2003
Mirtazapine for pruritus.
    Journal of pain and symptom management, 2003, Volume: 25, Issue:3

    Topics: Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Cholestasis; Female; Histamine H1 Antagon

2003
Management of chemotherapy-induced side-effects.
    The Lancet. Oncology, 2005, Volume: 6, Issue:6

    Topics: Antiemetics; Antineoplastic Agents; Histamine H1 Antagonists; Humans; Mianserin; Mirtazapine; Nausea

2005
Detection and treatment of depressive and anxiety disorders among cancer patients: feasibility and preliminary findings from a liaison service in an oncology division.
    Depression and anxiety, 2006, Volume: 23, Issue:7

    Topics: Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Citalopram; Depressive D

2006
Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects.
    European journal of cancer care, 2007, Volume: 16, Issue:4

    Topics: Antiemetics; Antineoplastic Agents; Benzodiazepines; Cachexia; Humans; Mianserin; Mirtazapine; Nause

2007
Mirtazapine for depression and comorbidities in older patients with cancer.
    The Annals of pharmacotherapy, 2007, Volume: 41, Issue:9

    Topics: Aged; Antidepressive Agents, Tricyclic; Antiemetics; Comorbidity; Depression; Humans; Mianserin; Mir

2007