mirtazapine has been researched along with Fibromyalgia in 6 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Fibromyalgia: A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy and safety of mirtazapine in Japanese patients with fibromyalgia (FM), a parallel-group, randomized, double-blind, placebo-controlled phase IIa study was conducted at 57 sites between November 2012 and February 2014." | 9.22 | Efficacy of mirtazapine for the treatment of fibromyalgia without concomitant depression: a randomized, double-blind, placebo-controlled phase IIa study in Japan. ( Miki, K; Murakami, M; Oka, H; Onozawa, K; Osada, K; Yoshida, S, 2016) |
| " Eighteen patients had at least moderate depression before mirtazapine treatment and 8 patients presented mild depressive symptoms." | 9.11 | Open trial of mirtazapine in patients with fibromyalgia. ( Lezanska-Szpera, M; Rybakowski, JK; Samborski, W, 2004) |
| "To assess the efficacy, tolerability and safety of the tetracyclic antidepressant, mirtazapine, compared with placebo or other active drug(s) in the treatment of fibromyalgia in adults." | 8.98 | Mirtazapine for fibromyalgia in adults. ( Bernardy, K; Derry, S; Häuser, W; Moore, RA; Welsch, P, 2018) |
| "On the background of a restricted armamentarium of drugs available for the management of fibromyalgia (FM), we aimed to compare the real-world effectiveness of two serotonin-norepinephrine reuptake inhibitors (SNRIs), mirtazapine (MTZ) and duloxetine (DLX) in FM." | 8.12 | Effectiveness and adverse effects of the use of mirtazapine as compared to duloxetine for fibromyalgia: real-life data from a retrospective cohort. ( Ahmed, S; Basu, A; Mehta, P, 2022) |
| " Study durations ranged from 6 to 13 weeks and studies used varying dosing strategies for mirtazapine." | 6.58 | The role of mirtazapine in patients with fibromyalgia: a systematic review. ( Brown, JN; Ottman, AA; Warner, CB, 2018) |
| "To evaluate the efficacy and safety of mirtazapine in Japanese patients with fibromyalgia (FM), a parallel-group, randomized, double-blind, placebo-controlled phase IIa study was conducted at 57 sites between November 2012 and February 2014." | 5.22 | Efficacy of mirtazapine for the treatment of fibromyalgia without concomitant depression: a randomized, double-blind, placebo-controlled phase IIa study in Japan. ( Miki, K; Murakami, M; Oka, H; Onozawa, K; Osada, K; Yoshida, S, 2016) |
| " Eighteen patients had at least moderate depression before mirtazapine treatment and 8 patients presented mild depressive symptoms." | 5.11 | Open trial of mirtazapine in patients with fibromyalgia. ( Lezanska-Szpera, M; Rybakowski, JK; Samborski, W, 2004) |
| "To assess the efficacy, tolerability and safety of the tetracyclic antidepressant, mirtazapine, compared with placebo or other active drug(s) in the treatment of fibromyalgia in adults." | 4.98 | Mirtazapine for fibromyalgia in adults. ( Bernardy, K; Derry, S; Häuser, W; Moore, RA; Welsch, P, 2018) |
| "On the background of a restricted armamentarium of drugs available for the management of fibromyalgia (FM), we aimed to compare the real-world effectiveness of two serotonin-norepinephrine reuptake inhibitors (SNRIs), mirtazapine (MTZ) and duloxetine (DLX) in FM." | 4.12 | Effectiveness and adverse effects of the use of mirtazapine as compared to duloxetine for fibromyalgia: real-life data from a retrospective cohort. ( Ahmed, S; Basu, A; Mehta, P, 2022) |
| " Study durations ranged from 6 to 13 weeks and studies used varying dosing strategies for mirtazapine." | 2.58 | The role of mirtazapine in patients with fibromyalgia: a systematic review. ( Brown, JN; Ottman, AA; Warner, CB, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mehta, P | 1 |
| Basu, A | 1 |
| Ahmed, S | 1 |
| Ottman, AA | 1 |
| Warner, CB | 1 |
| Brown, JN | 1 |
| Welsch, P | 1 |
| Bernardy, K | 1 |
| Derry, S | 1 |
| Moore, RA | 1 |
| Häuser, W | 1 |
| Miki, K | 1 |
| Murakami, M | 1 |
| Oka, H | 1 |
| Onozawa, K | 1 |
| Yoshida, S | 1 |
| Osada, K | 1 |
| Samborski, W | 2 |
| Lezanska-Szpera, M | 2 |
| Rybakowski, JK | 2 |
2 reviews available for mirtazapine and Fibromyalgia
| Article | Year |
|---|---|
The role of mirtazapine in patients with fibromyalgia: a systematic review.
Topics: Fibromyalgia; Health Status; Humans; Mirtazapine; Neurotransmitter Agents; Pain Threshold; Quality o | 2018 |
Mirtazapine for fibromyalgia in adults.
Topics: Adult; Antidepressive Agents, Tricyclic; Fibromyalgia; Humans; Mianserin; Mirtazapine; Randomized Co | 2018 |
3 trials available for mirtazapine and Fibromyalgia
| Article | Year |
|---|---|
Efficacy of mirtazapine for the treatment of fibromyalgia without concomitant depression: a randomized, double-blind, placebo-controlled phase IIa study in Japan.
Topics: Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Depression; Double-Blind Method; Fema | 2016 |
Open trial of mirtazapine in patients with fibromyalgia.
Topics: Adrenergic alpha-Antagonists; Adult; Depression; Drug Administration Schedule; Female; Fibromyalgia; | 2004 |
Effects of antidepressant mirtazapine on fibromyalgia symptoms.
Topics: Adult; Antidepressive Agents, Tricyclic; Female; Fibromyalgia; Humans; Male; Mianserin; Middle Aged; | 2004 |
1 other study available for mirtazapine and Fibromyalgia
| Article | Year |
|---|---|
Effectiveness and adverse effects of the use of mirtazapine as compared to duloxetine for fibromyalgia: real-life data from a retrospective cohort.
Topics: Duloxetine Hydrochloride; Female; Fibromyalgia; Humans; Male; Middle Aged; Mirtazapine; Retrospectiv | 2022 |