mirtazapine has been researched along with Drug Withdrawal Symptoms in 17 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study sought to determine whether chronic dosing of mirtazapine during cocaine withdrawal reduced depression- and anxiety-like behaviors that characterize cocaine withdrawal in animals." | 7.91 | Mirtazapine attenuates anxiety- and depression-like behaviors in rats during cocaine withdrawal. ( Barbosa Méndez, S; Salazar-Juárez, A, 2019) |
| "Here we present the case of a 30-year-old woman with type I diabetes mellitus, preeclampsia and treatment resistant persistent hyperemesis gravidarum in her 25th week of gestation who was successfully treated with the antidepressant mirtazapine (Remergil)." | 7.74 | Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine. ( Gembruch, U; Heep, A; Rohde, A; Schwarzer, V, 2008) |
| "A 23-year-old man with a history of alcohol dependence was admitted to our hospital after self-intoxication with 2700 mg baclofen and 330 mg mirtazapine." | 5.43 | [Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms]. ( de Witte, LD; Dekker, D; Kaasjager, K; Kromkamp, M; Veraart, J; Vinkers, CH, 2016) |
| "The objective of the present study was to determine whether a combined psychotherapeutic-psychopharmacological (with mirtazapine) treatment of collateral anxiety and depressive symptomatology during the post-withdrawal phase of alcoholism facilitates the process of alcohol detoxification, which is a decisive stage in the treatment of alcohol-dependent individuals." | 5.11 | Mirtazapine improves alcohol detoxification. ( Christodoulou, G; Liappas, J; Malitas, P; Paparrigopoulos, T; Tzavellas, E, 2004) |
| "This study sought to determine whether chronic dosing of mirtazapine during cocaine withdrawal reduced depression- and anxiety-like behaviors that characterize cocaine withdrawal in animals." | 3.91 | Mirtazapine attenuates anxiety- and depression-like behaviors in rats during cocaine withdrawal. ( Barbosa Méndez, S; Salazar-Juárez, A, 2019) |
| "Here we present the case of a 30-year-old woman with type I diabetes mellitus, preeclampsia and treatment resistant persistent hyperemesis gravidarum in her 25th week of gestation who was successfully treated with the antidepressant mirtazapine (Remergil)." | 3.74 | Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine. ( Gembruch, U; Heep, A; Rohde, A; Schwarzer, V, 2008) |
| "Modafinil-treated participants had a milder withdrawal syndrome as measured by the Amphetamine Cessation Symptom Assessment and less sleep disturbance in comparison to mirtazapine." | 2.73 | Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual. ( McGregor, C; Mitchell, A; Srisurapanont, M; White, JM; Wickes, W, 2008) |
| " Thus, the objective of this study was to determine if dosing of mirtazapine in an enriched housing environment enhanced the mirtazapine-induced decrease on the induction and expression of cocaine-induced locomotor sensitization." | 1.62 | Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats. ( Barbosa-Méndez, S; López-Morado, C; Salazar-Juárez, A, 2021) |
| "A 23-year-old man with a history of alcohol dependence was admitted to our hospital after self-intoxication with 2700 mg baclofen and 330 mg mirtazapine." | 1.43 | [Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms]. ( de Witte, LD; Dekker, D; Kaasjager, K; Kromkamp, M; Veraart, J; Vinkers, CH, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
| Authors | Studies |
|---|---|
| Ciccarone, D | 1 |
| Shoptaw, S | 1 |
| Barbosa-Méndez, S | 1 |
| López-Morado, C | 1 |
| Salazar-Juárez, A | 2 |
| Barbosa Méndez, S | 1 |
| Arora, S | 1 |
| Vohora, D | 1 |
| de Witte, LD | 1 |
| Dekker, D | 1 |
| Veraart, J | 1 |
| Kromkamp, M | 1 |
| Kaasjager, K | 1 |
| Vinkers, CH | 1 |
| Chandrasekaran, PK | 1 |
| Kang, L | 1 |
| Wang, D | 1 |
| Li, B | 1 |
| Hu, M | 1 |
| Zhang, P | 1 |
| Li, J | 1 |
| Haney, M | 1 |
| Hart, CL | 1 |
| Vosburg, SK | 1 |
| Comer, SD | 1 |
| Reed, SC | 1 |
| Cooper, ZD | 1 |
| Foltin, RW | 1 |
| Liappas, J | 2 |
| Paparrigopoulos, T | 2 |
| Malitas, P | 1 |
| Tzavellas, E | 2 |
| Christodoulou, G | 1 |
| Rabavilas, A | 1 |
| Schwarzer, V | 1 |
| Heep, A | 1 |
| Gembruch, U | 1 |
| Rohde, A | 1 |
| McGregor, C | 1 |
| Srisurapanont, M | 1 |
| Mitchell, A | 1 |
| Wickes, W | 1 |
| White, JM | 1 |
| Benyamina, A | 1 |
| Lecacheux, M | 1 |
| Blecha, L | 1 |
| Reynaud, M | 1 |
| Lukasiewcz, M | 1 |
| Cruickshank, CC | 1 |
| Montebello, ME | 1 |
| Dyer, KR | 1 |
| Quigley, A | 1 |
| Blaszczyk, J | 1 |
| Tomkins, S | 1 |
| Shand, D | 1 |
| Benazzi, F | 1 |
| MacCall, C | 1 |
| Callender, J | 1 |
| Klesmer, J | 1 |
| Sarcevic, A | 1 |
| Fomari, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Baclofen on Marijuana Withdrawal and Relapse[NCT00373295] | Phase 2 | 13 participants (Actual) | Interventional | 2006-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"This is a measure of marijuana self-administration and relapse since each initial puff costs $7 and is a burden to overcome just to smoke.~Over each 3 day period, the puffs chosen by each participant is averaged for a single value." (NCT00373295)
Timeframe: Days 1-3 (Baseline) and Days 6-8 (Relapse Phase)
| Intervention | dollars spent on marijuana (Mean) |
|---|---|
| Baclofen 60, Marijuana | 7.15 |
| Placebo, Marijuana | 9.77 |
| Baclofen 90, Marijuana | 7.25 |
2 reviews available for mirtazapine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Understanding Stimulant Use and Use Disorders in a New Era.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adult; Anticonvulsants; Behavior Therapy; Bupropion; Centra | 2022 |
Pharmacotherapy and psychotherapy in cannabis withdrawal and dependence.
Topics: Behavior Therapy; Buspirone; Cannabinoids; Cognitive Behavioral Therapy; Combined Modality Therapy; | 2008 |
5 trials available for mirtazapine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Effects of baclofen and mirtazapine on a laboratory model of marijuana withdrawal and relapse.
Topics: Adrenergic alpha-Antagonists; Adult; Affect; Baclofen; Cognition; Dose-Response Relationship, Drug; | 2010 |
Mirtazapine improves alcohol detoxification.
Topics: Adolescent; Adult; Alcoholism; Antidepressive Agents, Tricyclic; Combined Modality Therapy; Female; | 2004 |
Mirtazapine and venlafaxine in the management of collateral psychopathology during alcohol detoxification.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Anxiety; Central Nervous System Depressants; | 2005 |
Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: a comparison of mirtazapine and modafinil with treatment as usual.
Topics: Adult; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Centra | 2008 |
A placebo-controlled trial of mirtazapine for the management of methamphetamine withdrawal.
Topics: Adult; Ambulatory Care; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Central Ner | 2008 |
10 other studies available for mirtazapine and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Mirtazapine-induced decrease in cocaine sensitization is enhanced by environmental enrichment in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dopamine Uptak | 2021 |
Mirtazapine attenuates anxiety- and depression-like behaviors in rats during cocaine withdrawal.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Cocaine; Depression; Disease Models, Anim | 2019 |
Comparative Evaluation of Partial α2 -Adrenoceptor Agonist and Pure α2 -Adrenoceptor Antagonist on the Behavioural Symptoms of Withdrawal after Chronic Alcohol Administration in Mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Alcoholism; Animals; Anxiety; Be | 2016 |
[Aggression and restlessness following baclofen overdose: the narrow line between intoxication and withdrawal symptoms].
Topics: Adult; Aggression; Alcoholism; Baclofen; Delirium; Drug Overdose; GABA-B Receptor Agonists; Humans; | 2016 |
Employing mirtazapine to aid benzodiazepine withdrawal.
Topics: Adult; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Humans; Male; Mianserin; Midazolam; Mi | 2008 |
Mirtazapine, a noradrenergic and specific serotonergic antidepressant, attenuates morphine dependence and withdrawal in Sprague-Dawley rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Conditioning, Operant; Dose-Response Relationship, Drug; | 2008 |
Treatment resistant hyperemesis gravidarum in a patient with type 1 diabetes mellitus: neonatal withdrawal symptoms after successful antiemetic therapy with mirtazapine.
Topics: Adult; Antidepressive Agents, Tricyclic; Diabetes Mellitus, Type 1; Drug Resistance; Female; Humans; | 2008 |
Mirtazapine withdrawal symptoms.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Therapy, Combination; Humans; Mal | 1998 |
Mirtazapine withdrawal causing hypomania.
Topics: Aged; Antidepressive Agents, Tricyclic; Bipolar Disorder; Female; Humans; Mianserin; Mirtazapine; Su | 1999 |
Panic attacks during discontinuation of mirtazepine.
Topics: Antidepressive Agents, Tricyclic; Appendectomy; Dysthymic Disorder; Hernia, Umbilical; Humans; Male; | 2000 |