mirtazapine has been researched along with Disorders of Excessive Somnolence in 6 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Disorders of Excessive Somnolence: Disorders characterized by hypersomnolence during normal waking hours that may impair cognitive functioning. Subtypes include primary hypersomnia disorders (e.g., IDIOPATHIC HYPERSOMNOLENCE; NARCOLEPSY; and KLEINE-LEVIN SYNDROME) and secondary hypersomnia disorders where excessive somnolence can be attributed to a known cause (e.g., drug affect, MENTAL DISORDERS, and SLEEP APNEA SYNDROME). (From J Neurol Sci 1998 Jan 8;153(2):192-202; Thorpy, Principles and Practice of Sleep Medicine, 2nd ed, p320)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to conduct a naturalistic, open-label examination of the efficacy and tolerability of mirtazapine (a medication with both serotonergic and noradrenergic properties) in the treatment of associated symptoms of autism and other pervasive developmental disorders (PDDs)." | 5.09 | A naturalistic open-label study of mirtazapine in autistic and other pervasive developmental disorders. ( Guenin, KD; Kohn, AE; McDougle, CJ; Posey, DJ; Swiezy, NB, 2001) |
| "Insomnia and daytime sleepiness are often associated with depression." | 2.42 | Daytime sleepiness and insomnia as correlates of depression. ( Fava, M, 2004) |
| "In an animal model of central apnea the use of mirtazapine produced a significant reduction of apneas." | 1.32 | Effectiveness of mirtazapine in the treatment of sleep apnea/hypopnea syndrome (SAHS). ( Castillo, JL; Guilleminault, C; Menendez, P; Segovia, L, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brunette, MF | 1 |
| Akerman, SC | 1 |
| Dawson, R | 1 |
| O'Keefe, CD | 1 |
| Green, AI | 1 |
| Davis, MP | 1 |
| Kirkova, J | 1 |
| Lagman, R | 1 |
| Walsh, D | 1 |
| Karafa, M | 1 |
| Castillo, JL | 1 |
| Menendez, P | 1 |
| Segovia, L | 1 |
| Guilleminault, C | 1 |
| Fava, M | 1 |
| Han, C | 1 |
| Pae, CU | 1 |
| Lee, BH | 1 |
| Ko, YH | 1 |
| Masand, PS | 1 |
| Patkar, AA | 1 |
| Joe, SH | 1 |
| Jung, IK | 1 |
| Posey, DJ | 1 |
| Guenin, KD | 1 |
| Kohn, AE | 1 |
| Swiezy, NB | 1 |
| McDougle, CJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Music to Improve Sleep Quality in Adults With Depression and Insomnia: a Randomized Controlled Trial Using Mixed Methods[NCT03676491] | 112 participants (Actual) | Interventional | 2018-05-23 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mirtazapine and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
Daytime sleepiness and insomnia as correlates of depression.
Topics: Antidepressive Agents; Benzhydryl Compounds; Bupropion; Comorbidity; Depressive Disorder; Disorders | 2004 |
2 trials available for mirtazapine and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
Venlafaxine versus mirtazapine in the treatment of undifferentiated somatoform disorder: a 12-week prospective, open-label, randomized, parallel-group trial.
Topics: Adult; Antidepressive Agents; Cyclohexanols; Diagnostic and Statistical Manual of Mental Disorders; | 2008 |
A naturalistic open-label study of mirtazapine in autistic and other pervasive developmental disorders.
Topics: Adolescent; Adult; Aggression; Antidepressive Agents, Tricyclic; Anxiety Disorders; Appetite; Autist | 2001 |
3 other studies available for mirtazapine and Disorders of Excessive Somnolence
| Article | Year |
|---|---|
An open-label pilot study of quetiapine plus mirtazapine for heavy drinkers with alcohol use disorder.
Topics: Adrenergic alpha-Antagonists; Adult; Alcohol Drinking; Alcohol-Related Disorders; Antipsychotic Agen | 2016 |
Intolerance to mirtazapine in advanced cancer.
Topics: Aged; Antidepressive Agents; Depressive Disorder; Disorders of Excessive Somnolence; Female; Humans; | 2011 |
Effectiveness of mirtazapine in the treatment of sleep apnea/hypopnea syndrome (SAHS).
Topics: Aged, 80 and over; Antidepressive Agents, Tricyclic; Continuous Positive Airway Pressure; Disorders | 2004 |