mirtazapine has been researched along with Chronic Illness in 30 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Mirtazapine has a prophylactic and ibuprofen an acute effect in tension-type headache." | 9.12 | Combination of low-dose mirtazapine and ibuprofen for prophylaxis of chronic tension-type headache. ( Ashina, S; Bendtsen, L; Buchgreitz, L; Jensen, R, 2007) |
| "Six cases where mirtazapine, a noradrenergic and specific serotonergic antidepressant, was used to treat chronic breathlessness in advanced lung disease." | 7.88 | Use of mirtazapine in patients with chronic breathlessness: A case series. ( Bajwah, S; Higginson, IJ; Lovell, N; Maddocks, M; Wilcock, A, 2018) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 7.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study." | 7.73 | The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006) |
| "We present the cases of two elderly patients with intermittent long-term tramadol intake against chronic back pain." | 7.73 | Unrecognised long-lasting tramadol-induced delirium in two elderly patients. A case report. ( Dätwyler, S; Eschen, A; Künig, G; Schreiter Gasser, U, 2006) |
| "The effect of mirtazapine on steady-state plasma concentrations of the newer atypical antipsychotics clozapine, risperidone and olanzapine was investigated in 24 patients with chronic schizophrenia." | 7.72 | Lack of a pharmacokinetic interaction between mirtazapine and the newer antipsychotics clozapine, risperidone and olanzapine in patients with chronic schizophrenia. ( Canale, A; Crucitti, D; D'Arrigo, C; Malara, G; Muscatello, MR; Spina, E; Torre, DL; Zoccali, R, 2003) |
| "Mirtazapine is a relatively new so-called noradrenergic and specific serotonergic antidepressant, which is more specific and therefore generally better tolerated." | 6.71 | Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. ( Bendtsen, L; Jensen, R, 2004) |
| " Mirtazapine has a prophylactic and ibuprofen an acute effect in tension-type headache." | 5.12 | Combination of low-dose mirtazapine and ibuprofen for prophylaxis of chronic tension-type headache. ( Ashina, S; Bendtsen, L; Buchgreitz, L; Jensen, R, 2007) |
| "Six cases where mirtazapine, a noradrenergic and specific serotonergic antidepressant, was used to treat chronic breathlessness in advanced lung disease." | 3.88 | Use of mirtazapine in patients with chronic breathlessness: A case series. ( Bajwah, S; Higginson, IJ; Lovell, N; Maddocks, M; Wilcock, A, 2018) |
| "The effects of acute, systemic administration of amitriptyline, duloxetine and mirtazapine (antidepressant drugs that variously affect extracellular noradrenaline and serotonin levels) and the selective serotonin reuptake inhibitor (SSRI) citalopram were compared in rat models of experimental pain." | 3.73 | Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. ( Blackburn-Munro, G; Bomholt, SF; Mikkelsen, JD, 2005) |
| "To evaluate the safety, tolerability and efficacy of mirtazapine in patients with the primary diagnosis of chronic pain and concomitant depression in an open post-marketing surveillance study." | 3.73 | The effect of mirtazapine in patients with chronic pain and concomitant depression. ( Freynhagen, R; Lipfert, P; Muth-Selbach, U; Stevens, MF; Tölle, TR; von Giesen, HJ; Zacharowski, K, 2006) |
| "We present the cases of two elderly patients with intermittent long-term tramadol intake against chronic back pain." | 3.73 | Unrecognised long-lasting tramadol-induced delirium in two elderly patients. A case report. ( Dätwyler, S; Eschen, A; Künig, G; Schreiter Gasser, U, 2006) |
| "The effect of mirtazapine on steady-state plasma concentrations of the newer atypical antipsychotics clozapine, risperidone and olanzapine was investigated in 24 patients with chronic schizophrenia." | 3.72 | Lack of a pharmacokinetic interaction between mirtazapine and the newer antipsychotics clozapine, risperidone and olanzapine in patients with chronic schizophrenia. ( Canale, A; Crucitti, D; D'Arrigo, C; Malara, G; Muscatello, MR; Spina, E; Torre, DL; Zoccali, R, 2003) |
| "The co-occurrence of substance use disorder (SUD) and major depressive disorder (MDD) is common and is often thought to impair response to antidepressant therapy." | 2.77 | Effect of concurrent substance use disorder on the effectiveness of single and combination antidepressant medications for the treatment of major depression: an exploratory analysis of a single-blind randomized trial. ( Balasubramani, GK; Davis, LL; Fava, M; Gaynes, BN; Howland, RH; Pilkinton, P; Rush, AJ; Trivedi, MH; Wisniewski, SR; Zisook, S, 2012) |
| "Mirtazapine adjunction was well tolerated and induced a significant improvement in cognitive performance, as measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS; Randolph, 1998) total score and by the subscales for immediate and delayed memory (p<." | 2.73 | Add-on mirtazapine enhances effects on cognition in schizophrenic patients under stabilized treatment with clozapine. ( Biondi, M; Delle Chiaie, R; Fiorentini, S; Salviati, M, 2007) |
| "Mirtazapine is a relatively new so-called noradrenergic and specific serotonergic antidepressant, which is more specific and therefore generally better tolerated." | 2.71 | Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache. ( Bendtsen, L; Jensen, R, 2004) |
| "Steroids were restarted and his ataxia stabilized." | 1.46 | JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7. ( Angeles, MR; Bucelli, RC; Clifford, DB; Dang, X; Koralnik, IJ; Kuhlmann, FM; Major, EO; Ryschkewitsch, CF; Schmidt, RE; Schwetye, KE; Soleimani-Meigooni, DN, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 19 (63.33) | 29.6817 |
| 2010's | 8 (26.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, HG | 1 |
| Grossman, SK | 1 |
| Valdes-Rodriguez, R | 1 |
| Berenato, F | 1 |
| Korbutov, J | 1 |
| Chan, YH | 1 |
| Lavery, MJ | 1 |
| Yosipovitch, G | 2 |
| Lovell, N | 1 |
| Bajwah, S | 1 |
| Maddocks, M | 1 |
| Wilcock, A | 1 |
| Higginson, IJ | 1 |
| Bernhard, JD | 1 |
| Warden, D | 2 |
| Trivedi, MH | 4 |
| Carmody, T | 1 |
| Toups, M | 1 |
| Zisook, S | 2 |
| Lesser, I | 1 |
| Myers, A | 1 |
| Kurian, KR | 1 |
| Morris, D | 1 |
| Rush, AJ | 3 |
| Smith, JH | 1 |
| Soleimani-Meigooni, DN | 1 |
| Schwetye, KE | 1 |
| Angeles, MR | 1 |
| Ryschkewitsch, CF | 1 |
| Major, EO | 1 |
| Dang, X | 1 |
| Koralnik, IJ | 1 |
| Schmidt, RE | 1 |
| Clifford, DB | 1 |
| Kuhlmann, FM | 1 |
| Bucelli, RC | 1 |
| Khan, AY | 1 |
| Golewale, MH | 1 |
| Kahn, DA | 1 |
| Klein, DN | 1 |
| Arnow, BA | 1 |
| Barkin, JL | 1 |
| Dowling, F | 1 |
| Kocsis, JH | 1 |
| Leon, AC | 1 |
| Manber, R | 1 |
| Rothbaum, BO | 1 |
| Wisniewski, SR | 3 |
| Davis, LL | 1 |
| Pilkinton, P | 1 |
| Gaynes, BN | 1 |
| Howland, RH | 1 |
| Balasubramani, GK | 1 |
| Fava, M | 2 |
| Sung, SC | 1 |
| Haley, CL | 1 |
| Nierenberg, AA | 3 |
| Morris, DW | 1 |
| Kurian, BT | 1 |
| Zoccali, R | 1 |
| Muscatello, MR | 1 |
| Torre, DL | 1 |
| Malara, G | 1 |
| Canale, A | 1 |
| Crucitti, D | 1 |
| D'Arrigo, C | 1 |
| Spina, E | 1 |
| Quitkin, FM | 1 |
| Kremer, C | 1 |
| Keller, MB | 3 |
| Thase, ME | 2 |
| Bendtsen, L | 2 |
| Jensen, R | 2 |
| Bomholt, SF | 1 |
| Mikkelsen, JD | 1 |
| Blackburn-Munro, G | 1 |
| Thormann, H | 1 |
| Bindslev-Jensen, C | 1 |
| Bigatà, X | 1 |
| Sais, G | 1 |
| Soler, F | 1 |
| Freynhagen, R | 1 |
| Muth-Selbach, U | 1 |
| Lipfert, P | 1 |
| Stevens, MF | 1 |
| Zacharowski, K | 1 |
| Tölle, TR | 1 |
| von Giesen, HJ | 1 |
| Gerrits, M | 1 |
| Bakker, PL | 1 |
| Koch, T | 1 |
| Ter Horst, GJ | 1 |
| Künig, G | 1 |
| Dätwyler, S | 1 |
| Eschen, A | 1 |
| Schreiter Gasser, U | 1 |
| Tajti, J | 1 |
| Almási, J | 1 |
| Buchgreitz, L | 1 |
| Ashina, S | 1 |
| Silver, N | 1 |
| Delle Chiaie, R | 1 |
| Salviati, M | 1 |
| Fiorentini, S | 1 |
| Biondi, M | 1 |
| Hoes, MJ | 1 |
| Zeijpveld, JH | 1 |
| Brannon, GE | 1 |
| Stone, KD | 1 |
| Panagides, J | 1 |
| Spierings, EL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combining Medications to Enhance Depression Outcomes[NCT00590863] | Phase 4 | 665 participants (Actual) | Interventional | 2008-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Quality of Life Inventory (QOLI) is a 32-item comprehensive self-report of satisfaction in 16 areas of life, such as love, work, and health. Each area is rated in terms of satisfaction and the relationship of that area to overall quality of life. It yields an overall raw score and satisfaction ratings for the 16 individual areas of life. The QOLI raw score is an average of weighted satisfaction ratings computed only over areas of life judged to be Important or Extremely Important to the respondent. Higher scores indicate higher reported quality of life. (NCT00590863)
Timeframe: Measured at Month 7
| Intervention | units on a scale (Mean) |
|---|---|
| Escitalopram + Bupropion SR | 0.6 |
| Venlafaxine XR + Mirtazapine | 0.4 |
| Escitalopram + Placebo | 0.4 |
Percentage of patients that achieve remission, as defined as QIDS total score below 6 for last 2 study visits. QIDS depression scores range from 0 (normal) to 27 (very severe). (NCT00590863)
Timeframe: Measured at Month 7
| Intervention | percentage of participants (Number) |
|---|---|
| Escitalopram + Bupropion SR | 46.6 |
| Venlafaxine XR + Mirtazapine | 41.8 |
| Escitalopram + Placebo | 46.0 |
4 reviews available for mirtazapine and Chronic Illness
| Article | Year |
|---|---|
Clinical practice. Chronic pruritus.
Topics: Amines; Antidepressive Agents, Tricyclic; Behavior Therapy; Chronic Disease; Cyclohexanecarboxylic A | 2013 |
[Effects of mirtazapine in patients with chronic tension-type headache. Literature review].
Topics: Age Factors; Analgesics; Chronic Disease; Female; Humans; Male; Mianserin; Mirtazapine; Prevalence; | 2006 |
Headache (chronic tension-type).
Topics: Amitriptyline; Analgesics, Non-Narcotic; Antidepressive Agents; Biofeedback, Psychology; Chronic Dis | 2007 |
The long-term treatment of depression.
Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Chronic Disease; Combined Modality Therapy; | 1999 |
8 trials available for mirtazapine and Chronic Illness
| Article | Year |
|---|---|
Adherence to antidepressant combinations and monotherapy for major depressive disorder: a CO-MED report of measurement-based care.
Topics: Adult; Antidepressive Agents; Bupropion; Chronic Disease; Citalopram; Cyclohexanols; Depressive Diso | 2014 |
Effect of concurrent substance use disorder on the effectiveness of single and combination antidepressant medications for the treatment of major depression: an exploratory analysis of a single-blind randomized trial.
Topics: Adolescent; Antidepressive Agents; Bupropion; Chronic Disease; Citalopram; Cyclohexanols; Depressive | 2012 |
The impact of chronic depression on acute and long-term outcomes in a randomized trial comparing selective serotonin reuptake inhibitor monotherapy versus each of 2 different antidepressant medication combinations.
Topics: Adolescent; Adult; Aged; Antidepressive Agents; Bupropion; Chronic Disease; Citalopram; Comorbidity; | 2012 |
Placebo-controlled continuation treatment with mirtazapine: acute pattern of response predicts relapse.
Topics: Adult; Aged; Antidepressive Agents; Chronic Disease; Depressive Disorder; Female; Humans; Long-Term | 2004 |
Mirtazapine is effective in the prophylactic treatment of chronic tension-type headache.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Area Under Curve; Chro | 2004 |
Combination of low-dose mirtazapine and ibuprofen for prophylaxis of chronic tension-type headache.
Topics: Adrenergic alpha-Antagonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dose- | 2007 |
Add-on mirtazapine enhances effects on cognition in schizophrenic patients under stabilized treatment with clozapine.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Antipsychotic Agents; Brief Psychiatric R | 2007 |
Efficacy of mirtazapine for prevention of depressive relapse: a placebo-controlled double-blind trial of recently remitted high-risk patients.
Topics: Adult; Chronic Disease; Depressive Disorder, Major; Double-Blind Method; Female; Follow-Up Studies; | 2001 |
18 other studies available for mirtazapine and Chronic Illness
| Article | Year |
|---|---|
Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability.
Topics: Aged; Amines; Amitriptyline; Analgesics; Chronic Disease; Cyclohexanecarboxylic Acids; Drug Therapy, | 2017 |
Use of mirtazapine in patients with chronic breathlessness: A case series.
Topics: Antidepressive Agents; Chronic Disease; Dyspnea; Humans; Interviews as Topic; Lung Neoplasms; Mirtaz | 2018 |
Mirtazapine for new daily persistent headache-associated chronic nausea.
Topics: Chronic Disease; Female; Headache; Histamine H1 Antagonists; Humans; Mianserin; Middle Aged; Mirtaza | 2015 |
JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7.
Topics: Aged; Ataxia; Chronic Disease; Hamartoma Syndrome, Multiple; Humans; Immunocompromised Host; Immunog | 2017 |
A case of chronic drug-induced neutropenia.
Topics: Anti-Anxiety Agents; Anti-Infective Agents; Anxiety Disorders; Chronic Disease; Female; Humans; Metr | 2008 |
Early adversity in chronic depression: clinical correlates and response to pharmacotherapy.
Topics: Adolescent; Adult; Age of Onset; Aged; Algorithms; Antidepressive Agents; Anxiety Disorders; Bupropi | 2009 |
Lack of a pharmacokinetic interaction between mirtazapine and the newer antipsychotics clozapine, risperidone and olanzapine in patients with chronic schizophrenia.
Topics: Administration, Oral; Adult; Antipsychotic Agents; Benzodiazepines; Chronic Disease; Clinical Trials | 2003 |
[Unclear chronic aches. Often depression plays a part therein].
Topics: Acetates; Amines; Analgesics, Opioid; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Age | 2003 |
Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain.
Topics: Acute Disease; Amitriptyline; Analgesics; Animals; Antidepressive Agents; Chronic Disease; Citalopra | 2005 |
Mirtazapine for chronic urticaria.
Topics: Adrenergic alpha-Antagonists; Adult; Carbon Radioisotopes; Chronic Disease; Female; Humans; Male; Mi | 2004 |
Severe chronic urticaria: response to mirtazapine.
Topics: Adrenergic alpha-Antagonists; Aged; Chronic Disease; Female; Humans; Mianserin; Mirtazapine; Remissi | 2005 |
The effect of mirtazapine in patients with chronic pain and concomitant depression.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Tricyclic; Chronic Disease; Depre | 2006 |
Stress-induced sensitization of the limbic system in ovariectomized rats is partly restored by cyclic 17beta-estradiol administration.
Topics: Amygdala; Animals; Antidepressive Agents; Chronic Disease; Dentate Gyrus; Drug Interactions; Estradi | 2006 |
Unrecognised long-lasting tramadol-induced delirium in two elderly patients. A case report.
Topics: Adrenergic alpha-Antagonists; Aged; Analgesics, Opioid; Back Pain; Chronic Disease; Delirium; Drug I | 2006 |
Mirtazapine as treatment for serotonin syndrome.
Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Chronic Disease; Depressive Disorder; Female; Humans; | 1996 |
The use of mirtazapine in a patient with chronic pain.
Topics: Accidental Falls; Antidepressive Agents, Tricyclic; Back Pain; Chronic Disease; Humans; Male; Mianse | 1999 |
[Depressive disorders. A third have a chronic course].
Topics: Antidepressive Agents, Tricyclic; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Dr | 2001 |
Acute and chronic hypertensive headache and hypertensive encephalopathy.
Topics: Acute Disease; Antidepressive Agents; Antihypertensive Agents; Anxiety; Arterioles; Cerebral Arterie | 2002 |