mirtazapine has been researched along with Cachexia in 7 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia." | 9.41 | Mirtazapine in Cancer-Associated Anorexia and Cachexia: A Double-Blind Placebo-Controlled Randomized Trial. ( Abdel-Aal, HH; Alsirafy, SA; Elsherief, WA; Farag, DE; Hunter, CN; Riad, NM, 2021) |
| "We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)." | 9.14 | Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010) |
| "To investigate the effect of mirtazapine on tumor growth, food intake, body weight, and nutritional status in gemcitabine-induced mild cachexia." | 7.78 | Intervention of mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts. ( Jia, L; Jiang, SM; Wu, JH, 2012) |
| "Mirtazapine and olanzapine are easy-to-use psychiatric drugs with potent antinausea effects." | 7.74 | Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. ( Foley, KF; Kast, RE, 2007) |
| "This study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia." | 5.41 | Mirtazapine in Cancer-Associated Anorexia and Cachexia: A Double-Blind Placebo-Controlled Randomized Trial. ( Abdel-Aal, HH; Alsirafy, SA; Elsherief, WA; Farag, DE; Hunter, CN; Riad, NM, 2021) |
| "We performed an open-label single-institution phase II trial of mirtazapine (15-30 mg by mouth [po] every day [qd]), a tetracyclic antidepressant that may lead to weight gain, for 8 weeks in nondepressed patients with cancer-related cachexia/anorexia (CRCA)." | 5.14 | Phase II trial of mirtazapine for cancer-related cachexia and anorexia. ( Burman, D; Riechelmann, RP; Rodin, G; Tannock, IF; Zimmermann, C, 2010) |
| "To investigate the effect of mirtazapine on tumor growth, food intake, body weight, and nutritional status in gemcitabine-induced mild cachexia." | 3.78 | Intervention of mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts. ( Jia, L; Jiang, SM; Wu, JH, 2012) |
| "Mirtazapine and olanzapine are easy-to-use psychiatric drugs with potent antinausea effects." | 3.74 | Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects. ( Foley, KF; Kast, RE, 2007) |
| " Adverse events were commonly seen in the oncology population." | 1.72 | Propensity score-matching analysis comparing safety outcomes of appetite-stimulating medications in oncology patients. ( Burger, A; Eladghm, N; Gamaleldin, A; Marie Gavioli, E; Vider, E, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Marie Gavioli, E | 1 |
| Burger, A | 1 |
| Gamaleldin, A | 1 |
| Eladghm, N | 1 |
| Vider, E | 1 |
| Hunter, CN | 1 |
| Abdel-Aal, HH | 1 |
| Elsherief, WA | 1 |
| Farag, DE | 1 |
| Riad, NM | 1 |
| Alsirafy, SA | 1 |
| Fox, CB | 1 |
| Treadway, AK | 1 |
| Blaszczyk, AT | 1 |
| Sleeper, RB | 1 |
| Riechelmann, RP | 1 |
| Burman, D | 1 |
| Tannock, IF | 1 |
| Rodin, G | 1 |
| Zimmermann, C | 1 |
| Jiang, SM | 1 |
| Wu, JH | 1 |
| Jia, L | 1 |
| Schillerstrom, JE | 1 |
| Seaman, JS | 1 |
| Kast, RE | 1 |
| Foley, KF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-blind Clinical Trial of the Use of Mirtazapine Versus Megestrol for the Control of Anorexia-cachexia in Cancer Patients in Palliative Care.[NCT03283488] | Phase 2 | 52 participants (Actual) | Interventional | 2019-03-26 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for mirtazapine and Cachexia
| Article | Year |
|---|---|
Megestrol acetate and mirtazapine for the treatment of unplanned weight loss in the elderly.
Topics: Aged; Antidepressive Agents, Tricyclic; Appetite Stimulants; Cachexia; Case-Control Studies; Dose-Re | 2009 |
2 trials available for mirtazapine and Cachexia
| Article | Year |
|---|---|
Mirtazapine in Cancer-Associated Anorexia and Cachexia: A Double-Blind Placebo-Controlled Randomized Trial.
Topics: Anorexia; Cachexia; Double-Blind Method; Hand Strength; Humans; Mirtazapine; Neoplasms | 2021 |
Phase II trial of mirtazapine for cancer-related cachexia and anorexia.
Topics: Aged; Aged, 80 and over; Anorexia; Antidepressive Agents, Tricyclic; Appetite; Body Weight; Cachexia | 2010 |
4 other studies available for mirtazapine and Cachexia
| Article | Year |
|---|---|
Propensity score-matching analysis comparing safety outcomes of appetite-stimulating medications in oncology patients.
Topics: Adult; Aged; Anorexia; Appetite; Appetite Stimulants; Cachexia; Hallucinations; Humans; Long QT Synd | 2022 |
Intervention of mirtazapine on gemcitabine-induced mild cachexia in nude mice with pancreatic carcinoma xenografts.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Cachexia; Carcinoma; Cell Line, Tumor; Deoxyc | 2012 |
Modafinil augmentation of mirtazapine in a failure-to-thrive geriatric inpatient.
Topics: Aged; Antidepressive Agents, Tricyclic; Benzhydryl Compounds; Cachexia; Central Nervous System Stimu | 2002 |
Cancer chemotherapy and cachexia: mirtazapine and olanzapine are 5-HT3 antagonists with good antinausea effects.
Topics: Antiemetics; Antineoplastic Agents; Benzodiazepines; Cachexia; Humans; Mianserin; Mirtazapine; Nause | 2007 |