mirtazapine has been researched along with Apnea, Obstructive Sleep in 6 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mirtazapine is an a2A antagonist and mixed 5-HT2/5-HT3 antagonist that has been proposed as a potential treatment for obstructive sleep apnea (OSA)." | 2.73 | Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea. ( Buchanan, PR; Crompton, R; Desai, AV; Gendreau, RM; Grunstein, RR; Kranzler, J; Marshall, NS; Melehan, KL; Rao, SG; Wong, KK; Yee, BJ; Zack, N, 2008) |
| "The latter yielded results on VMS, insomnia, circadian rhythm disorders, obstructive sleep apnea (OSA) and restless leg syndrome (RLS)." | 2.61 | Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders. ( Aricò, I; Bonanni, E; Bonsignore, M; Caretto, M; Caruso, D; Di Perri, MC; Galletta, S; Lecca, RM; Lombardi, C; Maestri, M; Miccoli, M; Palagini, L; Provini, F; Puligheddu, M; Savarese, M; Silvestri, R; Simoncini, T; Spaggiari, MC, 2019) |
| "In an animal model of central apnea the use of mirtazapine produced a significant reduction of apneas." | 1.32 | Effectiveness of mirtazapine in the treatment of sleep apnea/hypopnea syndrome (SAHS). ( Castillo, JL; Guilleminault, C; Menendez, P; Segovia, L, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Silvestri, R | 1 |
| Aricò, I | 1 |
| Bonanni, E | 1 |
| Bonsignore, M | 1 |
| Caretto, M | 1 |
| Caruso, D | 1 |
| Di Perri, MC | 1 |
| Galletta, S | 1 |
| Lecca, RM | 1 |
| Lombardi, C | 1 |
| Maestri, M | 1 |
| Miccoli, M | 1 |
| Palagini, L | 1 |
| Provini, F | 1 |
| Puligheddu, M | 1 |
| Savarese, M | 1 |
| Spaggiari, MC | 1 |
| Simoncini, T | 1 |
| Marshall, NS | 1 |
| Yee, BJ | 1 |
| Desai, AV | 1 |
| Buchanan, PR | 1 |
| Wong, KK | 1 |
| Crompton, R | 1 |
| Melehan, KL | 1 |
| Zack, N | 2 |
| Rao, SG | 1 |
| Gendreau, RM | 1 |
| Kranzler, J | 2 |
| Grunstein, RR | 1 |
| Levendowski, DJ | 1 |
| Rao, S | 1 |
| Wong, K | 1 |
| Gendreau, M | 1 |
| Zavora, T | 1 |
| Westbrook, PR | 1 |
| Kohler, M | 1 |
| Bloch, KE | 1 |
| Stradling, JR | 1 |
| Castillo, JL | 1 |
| Menendez, P | 1 |
| Segovia, L | 1 |
| Guilleminault, C | 1 |
| Carley, DW | 1 |
| Olopade, C | 1 |
| Ruigt, GS | 1 |
| Radulovacki, M | 1 |
2 reviews available for mirtazapine and Apnea, Obstructive Sleep
| Article | Year |
|---|---|
Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders.
Topics: Antidepressive Agents; Cognitive Behavioral Therapy; Continuous Positive Airway Pressure; Depression | 2019 |
Pharmacological approaches to the treatment of obstructive sleep apnoea.
Topics: Animals; Cholinesterase Inhibitors; Humans; Mianserin; Mirtazapine; Protriptyline; Pulmonary Ventila | 2009 |
3 trials available for mirtazapine and Apnea, Obstructive Sleep
| Article | Year |
|---|---|
Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Drug Tolerance; Female; Histamine H1 Antagonists; Hu | 2008 |
Assessment of the test-retest reliability of laboratory polysomnography.
Topics: Adrenergic alpha-Antagonists; Adult; Body Mass Index; Continuous Positive Airway Pressure; Female; H | 2009 |
Efficacy of mirtazapine in obstructive sleep apnea syndrome.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cross-Over Studies; Dose-Response Relationship, Drug; | 2007 |
1 other study available for mirtazapine and Apnea, Obstructive Sleep
| Article | Year |
|---|---|
Effectiveness of mirtazapine in the treatment of sleep apnea/hypopnea syndrome (SAHS).
Topics: Aged, 80 and over; Antidepressive Agents, Tricyclic; Continuous Positive Airway Pressure; Disorders | 2004 |