mirtazapine has been researched along with Anxiety in 26 studies
Mirtazapine: A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was a 10-week double-blind, placebo-controlled pilot trial of mirtazapine for anxiety in youth with autism spectrum disorder (ASD)." | 9.51 | A randomized double-blind, placebo-controlled pilot trial of mirtazapine for anxiety in children and adolescents with autism spectrum disorder. ( Erickson, CA; Keary, CJ; Mathieu-Frasier, L; McDougle, CJ; Mullett, JE; Palumbo, ML; Politte, LC; Posey, DJ; Ravichandran, CT; Stigler, KA; Thom, RP, 2022) |
| "In a randomized, placebo-controlled trial, mirtazapine significantly improved early satiation, quality of life, gastrointestinal-specific anxiety, nutrient tolerance, and weight loss in patients with FD." | 9.22 | Efficacy of Mirtazapine in Patients With Functional Dyspepsia and Weight Loss. ( Arts, J; Boeckxstaens, G; Caenepeel, P; Carbone, F; Holvoet, L; Ly, HG; Tack, J; Van Oudenhove, L; Vanheel, H; Vanuytsel, T, 2016) |
| "The VAS anxiety scale was lower in group M + D after mirtazapine administration." | 9.13 | Premedication with mirtazapine reduces preoperative anxiety and postoperative nausea and vomiting. ( Chen, CC; Hsu, YW; Hung, YC; Ko, YP; Lao, HC; Lin, CS, 2008) |
| "This study sought to determine whether chronic dosing of mirtazapine during cocaine withdrawal reduced depression- and anxiety-like behaviors that characterize cocaine withdrawal in animals." | 7.91 | Mirtazapine attenuates anxiety- and depression-like behaviors in rats during cocaine withdrawal. ( Barbosa Méndez, S; Salazar-Juárez, A, 2019) |
| " In addition, a dose-response effect was seen with Org 3770, 15 mg seeming optimal." | 6.66 | A double-blind group comparative study using the new anti-depressant Org 3770, placebo and diazepam in patients with expected insomnia and anxiety before elective gynaecological surgery. ( Bettum, V; Dunbar, GC; Jørgensen, J; Steffensen, K; Sørensen, M; Viby-Mogensen, J, 1985) |
| "This study was a 10-week double-blind, placebo-controlled pilot trial of mirtazapine for anxiety in youth with autism spectrum disorder (ASD)." | 5.51 | A randomized double-blind, placebo-controlled pilot trial of mirtazapine for anxiety in children and adolescents with autism spectrum disorder. ( Erickson, CA; Keary, CJ; Mathieu-Frasier, L; McDougle, CJ; Mullett, JE; Palumbo, ML; Politte, LC; Posey, DJ; Ravichandran, CT; Stigler, KA; Thom, RP, 2022) |
| "In a randomized, placebo-controlled trial, mirtazapine significantly improved early satiation, quality of life, gastrointestinal-specific anxiety, nutrient tolerance, and weight loss in patients with FD." | 5.22 | Efficacy of Mirtazapine in Patients With Functional Dyspepsia and Weight Loss. ( Arts, J; Boeckxstaens, G; Caenepeel, P; Carbone, F; Holvoet, L; Ly, HG; Tack, J; Van Oudenhove, L; Vanheel, H; Vanuytsel, T, 2016) |
| "The VAS anxiety scale was lower in group M + D after mirtazapine administration." | 5.13 | Premedication with mirtazapine reduces preoperative anxiety and postoperative nausea and vomiting. ( Chen, CC; Hsu, YW; Hung, YC; Ko, YP; Lao, HC; Lin, CS, 2008) |
| "This study sought to determine whether chronic dosing of mirtazapine during cocaine withdrawal reduced depression- and anxiety-like behaviors that characterize cocaine withdrawal in animals." | 3.91 | Mirtazapine attenuates anxiety- and depression-like behaviors in rats during cocaine withdrawal. ( Barbosa Méndez, S; Salazar-Juárez, A, 2019) |
| " In the present study, female rats were treated long term with clinically used antidepressants (fluoxetine, nortriptyline or mirtazapine) and subjected to the plus-maze discriminative avoidance task to evaluate learning, memory, extinction and anxiety-related behaviors as well as behavioral despair in the forced swimming test." | 3.78 | Antidepressants differentially modify the extinction of an aversive memory task in female rats. ( Cabral, A; Ferreira, LS; Izídio, GS; Macedo, PT; Melo, TG; Ribeiro, AM; Silva, RH; Sousa, DS, 2012) |
| "Mirtazapine safety was assessed by interview during each follow-up period on days 3 and 14 after treatment." | 2.71 | Mirtazapine in amphetamine detoxification: a placebo-controlled pilot study. ( Kongsakon, R; Papadopoulos, KI; Saguansiritham, R, 2005) |
| "Imipramine was more effective against the clusters related to core symptoms of depression: "depression and guilt", "retardation", and "melancholia", respectively." | 2.69 | Depressed in-patients respond differently to imipramine and mirtazapine. ( Bruijn, JA; Moleman, P; Mulder, PG; van den Broek, WW, 1999) |
| " In addition, a dose-response effect was seen with Org 3770, 15 mg seeming optimal." | 2.66 | A double-blind group comparative study using the new anti-depressant Org 3770, placebo and diazepam in patients with expected insomnia and anxiety before elective gynaecological surgery. ( Bettum, V; Dunbar, GC; Jørgensen, J; Steffensen, K; Sørensen, M; Viby-Mogensen, J, 1985) |
| "Buspirone has an indication for generalized anxiety disorder though studies show only a minimal benefit." | 2.53 | Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD. ( Bielefeldt, K; Szigethy, E; Thorkelson, G, 2016) |
| " The sexual symptoms resolved gradually after a few days and reappeared upon every dosage increase." | 1.35 | A case of mirtazapine-induced spontaneous orgasms in a female patient. ( Ben-Zion, I; Shalev, H; Shiber, A, 2009) |
| " Long-term administration with imipramine or mirtazapine (10 mg/kg, i." | 1.31 | Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142-induced increase in cortical norepinephrine output in freely moving rats. ( Biggio, G; Dazzi, L; Ladu, S; Pira, L; Rivano, A; Spiga, F; Vacca, G, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.85) | 18.7374 |
| 1990's | 3 (11.54) | 18.2507 |
| 2000's | 9 (34.62) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| McDougle, CJ | 1 |
| Thom, RP | 1 |
| Ravichandran, CT | 1 |
| Palumbo, ML | 1 |
| Politte, LC | 1 |
| Mullett, JE | 1 |
| Keary, CJ | 1 |
| Erickson, CA | 1 |
| Stigler, KA | 1 |
| Mathieu-Frasier, L | 1 |
| Posey, DJ | 1 |
| Surowka, P | 1 |
| Noworyta, K | 1 |
| Cieslik, A | 1 |
| Rygula, R | 1 |
| Lim, LJH | 1 |
| Fong, LM | 1 |
| Hariram, J | 1 |
| Lee, YW | 1 |
| Tor, PC | 1 |
| Akama, F | 1 |
| Mikami, K | 1 |
| Watanabe, N | 1 |
| Kimoto, K | 1 |
| Yamamoto, K | 1 |
| Matsumoto, H | 1 |
| Barbosa Méndez, S | 1 |
| Salazar-Juárez, A | 1 |
| Tanidir, C | 1 |
| Tanidir, IC | 1 |
| Tuzcu, V | 1 |
| An, Y | 1 |
| Inoue, T | 1 |
| Kitaichi, Y | 1 |
| Nakagawa, S | 1 |
| Wang, C | 1 |
| Chen, C | 1 |
| Song, N | 1 |
| Kusumi, I | 1 |
| Tack, J | 1 |
| Ly, HG | 1 |
| Carbone, F | 1 |
| Vanheel, H | 1 |
| Vanuytsel, T | 1 |
| Holvoet, L | 1 |
| Boeckxstaens, G | 1 |
| Caenepeel, P | 1 |
| Arts, J | 1 |
| Van Oudenhove, L | 1 |
| Arora, S | 1 |
| Vohora, D | 1 |
| Huang, WL | 1 |
| Liao, SC | 1 |
| Kuo, TB | 1 |
| Chang, LR | 1 |
| Chen, TT | 1 |
| Chen, IM | 1 |
| Yang, CC | 1 |
| Thorkelson, G | 1 |
| Bielefeldt, K | 1 |
| Szigethy, E | 1 |
| Melo, TG | 1 |
| Izídio, GS | 1 |
| Ferreira, LS | 1 |
| Sousa, DS | 1 |
| Macedo, PT | 1 |
| Cabral, A | 1 |
| Ribeiro, AM | 1 |
| Silva, RH | 1 |
| Udo, I | 1 |
| Gash, A | 1 |
| Kesim, M | 1 |
| Yaris, F | 1 |
| Kadioglu, M | 1 |
| Yaris, E | 1 |
| Kalyoncu, NI | 1 |
| Ulku, C | 1 |
| Liappas, J | 1 |
| Paparrigopoulos, T | 1 |
| Tzavellas, E | 1 |
| Rabavilas, A | 1 |
| Kongsakon, R | 1 |
| Papadopoulos, KI | 1 |
| Saguansiritham, R | 1 |
| Chen, CC | 1 |
| Lin, CS | 1 |
| Ko, YP | 1 |
| Hung, YC | 1 |
| Lao, HC | 1 |
| Hsu, YW | 1 |
| Shalev, H | 1 |
| Ben-Zion, I | 1 |
| Shiber, A | 1 |
| Shchukina, EP | 1 |
| Kinkul'kina, MA | 1 |
| Gerritsen, AW | 1 |
| Bruijn, JA | 1 |
| Moleman, P | 1 |
| Mulder, PG | 1 |
| van den Broek, WW | 1 |
| Davis, J | 1 |
| Barkin, RL | 1 |
| Dazzi, L | 2 |
| Spiga, F | 2 |
| Pira, L | 2 |
| Ladu, S | 2 |
| Vacca, G | 2 |
| Rivano, A | 2 |
| Jentsch, JD | 1 |
| Biggio, G | 2 |
| Spierings, EL | 1 |
| Sørensen, M | 1 |
| Jørgensen, J | 1 |
| Viby-Mogensen, J | 1 |
| Bettum, V | 1 |
| Dunbar, GC | 1 |
| Steffensen, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders[NCT01302964] | Phase 3 | 30 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| Phase 4 Study of Mirtazapine in Functional Dyspepsia Patients With Weight Loss[NCT01240096] | Phase 4 | 35 participants (Anticipated) | Interventional | 2006-09-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Pediatric Anxiety Rating Scale (PARS) is a clinician-rated instrument that assesses anxiety symptoms that are commonly associated with social anxiety, separation anxiety, and generalized anxiety disorders. Scaled score ranges form 0-25 with higher scores indicating more severe anxiety symptoms. Means were estimated using a repeated measures linear regression model with treatment group, study week (in categories), and their interaction as covariates, and assuming a common mean between treatment groups at baseline. Confidence intervals reflect a Bonferroni multiple testing correction accounting for the selection of two primary outcomes. (NCT01302964)
Timeframe: Weeks Baseline, 2, 4, 6, and 10
| Intervention | score on a scale (Mean) |
|---|---|
| Mirtazapine | -4.9 |
| Placebo | -3.2 |
The Clinical Global Impressions Global Improvement (CGI-I) is designed to take into account all factors to arrive at an assessment of response to treatment. The CGI-I scale ranges from 1 to 7 (1=very much improved; 2= much improved; 3=minimally improved; 4=no change; 5=minimally worse; 6=much worse; 7=very much worse), with lower scores indicating improvement (1=very much improved and 2=much improved). In this study the CGI was focused on the target symptom of anxiety. Participants with a CGI-I score of 1 or 2 were classified as responders. The CGI-I was administered biweekly for 6 weeks and again at 10 weeks during the study. The participant who withdrew from the study before 10 weeks was not included in the calculations. (NCT01302964)
Timeframe: Screen (Visit 1) Baseline (Visit 2) and Endpoint (Week 10)
| Intervention | Proportion of participants (Number) |
|---|---|
| Mirtazapine | 0.47 |
| Placebo | 0.20 |
1 review available for mirtazapine and Anxiety
| Article | Year |
|---|---|
Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD.
Topics: Adolescent; Adult; Affect; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Bupropion | 2016 |
7 trials available for mirtazapine and Anxiety
| Article | Year |
|---|---|
A randomized double-blind, placebo-controlled pilot trial of mirtazapine for anxiety in children and adolescents with autism spectrum disorder.
Topics: Adolescent; Anxiety; Anxiety Disorders; Autism Spectrum Disorder; Child; Child, Preschool; Double-Bl | 2022 |
Efficacy of Mirtazapine in Patients With Functional Dyspepsia and Weight Loss.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Anxiety; Double-Blind Method; Dyspepsia; Female; Humans; | 2016 |
Mirtazapine and venlafaxine in the management of collateral psychopathology during alcohol detoxification.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Anxiety; Central Nervous System Depressants; | 2005 |
Mirtazapine in amphetamine detoxification: a placebo-controlled pilot study.
Topics: Adolescent; Adult; Amphetamine-Related Disorders; Antidepressive Agents, Tricyclic; Anxiety; Arousal | 2005 |
Premedication with mirtazapine reduces preoperative anxiety and postoperative nausea and vomiting.
Topics: Adult; Analgesics, Opioid; Anti-Anxiety Agents; Antiemetics; Anxiety; Double-Blind Method; Female; G | 2008 |
Depressed in-patients respond differently to imipramine and mirtazapine.
Topics: Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Antidepressive Agents, Tricyclic; Anxiety | 1999 |
A double-blind group comparative study using the new anti-depressant Org 3770, placebo and diazepam in patients with expected insomnia and anxiety before elective gynaecological surgery.
Topics: Adult; Anxiety; Blood Pressure; Diazepam; Dibenzazepines; Dose-Response Relationship, Drug; Double-B | 1985 |
18 other studies available for mirtazapine and Anxiety
| Article | Year |
|---|---|
Trait sensitivity to negative feedback determines the effects of chronic stress and chronic mirtazapine treatment on anxiety and stress-coping strategies in rats.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Anxiety; Disease Models, Animal; Feedback | 2022 |
COVID-19, a pandemic that affects more than just physical health: Two case reports.
Topics: Adjustment Disorders; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; COVID-19; Fear; Female; Hu | 2020 |
Efficacy of Mirtazapine on Irritable Bowel Syndrome with Anxiety and Depression: A Case Study.
Topics: Antidepressive Agents; Anxiety; Depression; Female; Humans; Irritable Bowel Syndrome; Middle Aged; M | 2018 |
Mirtazapine attenuates anxiety- and depression-like behaviors in rats during cocaine withdrawal.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Cocaine; Depression; Disease Models, Anim | 2019 |
Treatment of depression in an adolescent with cardiomyopathy and arrhythmia.
Topics: Adolescent; Antidepressive Agents, Tricyclic; Anxiety; Cardiomyopathy, Hypertrophic; Depression; Ele | 2015 |
Subchronic lithium treatment increases the anxiolytic-like effect of mirtazapine on the expression of contextual conditioned fear.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conditioning, Psychological; Dose-Response | 2015 |
Comparative Evaluation of Partial α2 -Adrenoceptor Agonist and Pure α2 -Adrenoceptor Antagonist on the Behavioural Symptoms of Withdrawal after Chronic Alcohol Administration in Mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Alcoholism; Animals; Anxiety; Be | 2016 |
The Effects of Antidepressants and Quetiapine on Heart Rate Variability.
Topics: Adult; Aged; Antidepressive Agents; Anxiety; Depression; Female; Heart Rate; Humans; Linear Models; | 2016 |
Antidepressants differentially modify the extinction of an aversive memory task in female rats.
Topics: Animals; Antidepressive Agents; Anxiety; Avoidance Learning; Extinction, Psychological; Female; Fluo | 2012 |
Challenges in management of complex panic disorder in a palliative care setting.
Topics: Anti-Anxiety Agents; Anxiety; Breathing Exercises; Comorbidity; Death; Dibenzothiazepines; Eye Movem | 2012 |
Mirtazapine use in two pregnant women: is it safe?
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Depression; Drug Therapy, Combination; Female; Fol | 2002 |
A case of mirtazapine-induced spontaneous orgasms in a female patient.
Topics: Antidepressive Agents, Tricyclic; Anxiety; Depressive Disorder; Female; Hospitals, Psychiatric; Huma | 2009 |
[Differentiated approach to the therapy of endogenous anxious depression].
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Carbon Radioisotopes; Depression; Female; Follow-U | 2007 |
Safety in overdose of mirtazapine: a case report.
Topics: Adult; Antidepressive Agents, Tricyclic; Anxiety; Confusion; Depressive Disorder; Dothiepin; Drug Ov | 1997 |
Clinical pharmacology of mirtazapine: revisited.
Topics: Agranulocytosis; Antidepressive Agents, Tricyclic; Anxiety; Depression; Humans; Mianserin; Mirtazapi | 1999 |
Inhibition of stress- or anxiogenic-drug-induced increases in dopamine release in the rat prefrontal cortex by long-term treatment with antidepressant drugs.
Topics: Animals; Antidepressive Agents; Anxiety; Carbolines; Dopamine; Dose-Response Relationship, Drug; Dru | 2001 |
Chronic treatment with imipramine or mirtazapine antagonizes stress- and FG7142-induced increase in cortical norepinephrine output in freely moving rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Carbolines; Cerebral Cortex | 2002 |
Acute and chronic hypertensive headache and hypertensive encephalopathy.
Topics: Acute Disease; Antidepressive Agents; Antihypertensive Agents; Anxiety; Arterioles; Cerebral Arterie | 2002 |