mirabegron and Pulmonary-Embolism

Changes in pulmonary microhemodynamics during modelling of pulmonary thromboembolism against the background of nebivolol and mirabegron pretreatment were studied in isolated perfused rabbit lungs. In both cases, the pulmonary artery pressure and precapillary and pulmonary vascular resistance increased to a greater extent than in control animals, but the increase in capillary hydrostatic pressure was less pronounced. The postcapillary resistance did not change in pulmonary embolism against the background of nebivolol administration and increased in case of mirabegron pretreatment; capillary filtration coefficient after nebivolol pretreatment increased less markedly than after mirabegron administration. The increase in capillary filtration coefficient after activation of β

Topics: Acetanilides; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Isoproterenol; Lung; Nebivolol; Propranolol; Pulmonary Circulation; Pulmonary Embolism; Rabbits; Receptors, Adrenergic, beta; Thiazoles; Vascular Resistance