minozac has been researched along with Alzheimer-Disease* in 1 studies
1 other study(ies) available for minozac and Alzheimer-Disease
| Article | Year |
|---|---|
Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits.
We report the development of a novel, aqueous-soluble, safe, small molecule, experimental therapeutic that suppresses injury-induced, proinflammatory cytokine increases in the brain, with resultant attenuation of synaptic protein biomarker loss and improvement in hippocampus-dependent behavioral deficits. A GMP production scheme for the active pharmaceutical ingredient, compound 17, is presented. The development and large-scale availability of this novel compound allow exploration of new, potentially disease-modifying, therapeutic approaches to CNS disorders. Topics: Alzheimer Disease; Animals; Astrocytes; Behavior, Animal; Biological Availability; Brain Chemistry; Chemical Phenomena; Chemistry, Physical; Cytokines; Drug Design; Glial Fibrillary Acidic Protein; Hippocampus; Magnetic Resonance Spectroscopy; Mice; Microglia; Nootropic Agents; Pyridazines; Pyrimidines; Rats; Synapses; Up-Regulation | 2007 |