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minoxidil and Tachycardia

minoxidil has been researched along with Tachycardia in 17 studies

Minoxidil: A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
minoxidil : A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.

Tachycardia: Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.

Research Excerpts

ExcerptRelevanceReference
"The effect of the new vasodilator, minoxidil, on blood pressure and plasma renin activity was studied in 21 hypertensive patients: 12 patients with essential and 9 with renal hypertension."9.04The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension. ( Werning, C, 1976)
"The effects of minoxidil on the electrocardiogram (EKG) were assessed in a prospective investigation of 112 patients with severe hypertension during an observation period representing 241."7.66Serial electrocardiographic changes during long-term treatment of severe hypertension with minoxidil. ( Froer, KL; Hall, D; Rudolph, W, 1980)
"Minoxidil is a potent antihypertensive drug widely used in severe arterial hypertension and in that refractory to treatment."7.66Minoxidil in severe and moderately severe hypertension, in association with methyldopa and chlortalidone. ( Cotorruelo, JG; Flórez, J; Llamazares, C, 1982)
" Propranolol and furosemide were administered concomitantly to control reflex tachycardia and fluid retention."7.65The outpatient treatment of refractory hypertension with minoxidil. ( Ball, JH; Kleiner, JP; Nelson, WP; Norton, JD, 1977)
" Propranolol and diuretics were given to prevent reflex tachycardia and fluid retention."7.65Severe hypertension. Treatment with minoxidil. ( Dunea, G; Mahurkar, SD; Mamdani, B; Mehta, PK; Shansky, RM, 1975)
"Propranolol was demonstrated to block hydralazine-induced increases in serum renin activity in genetically hypertensive rats."5.25Altered renin release and propranolol potentiation of vasodilatory drug hypotension. ( Keeton, K; Pettinger, WA, 1975)
"The effect of the new vasodilator, minoxidil, on blood pressure and plasma renin activity was studied in 21 hypertensive patients: 12 patients with essential and 9 with renal hypertension."5.04The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension. ( Werning, C, 1976)
"The effects of minoxidil on the electrocardiogram (EKG) were assessed in a prospective investigation of 112 patients with severe hypertension during an observation period representing 241."3.66Serial electrocardiographic changes during long-term treatment of severe hypertension with minoxidil. ( Froer, KL; Hall, D; Rudolph, W, 1980)
"Minoxidil is a potent antihypertensive drug widely used in severe arterial hypertension and in that refractory to treatment."3.66Minoxidil in severe and moderately severe hypertension, in association with methyldopa and chlortalidone. ( Cotorruelo, JG; Flórez, J; Llamazares, C, 1982)
" Propranolol and furosemide were administered concomitantly to control reflex tachycardia and fluid retention."3.65The outpatient treatment of refractory hypertension with minoxidil. ( Ball, JH; Kleiner, JP; Nelson, WP; Norton, JD, 1977)
" Propranolol and diuretics were given to prevent reflex tachycardia and fluid retention."3.65Severe hypertension. Treatment with minoxidil. ( Dunea, G; Mahurkar, SD; Mamdani, B; Mehta, PK; Shansky, RM, 1975)
"The major concern regarding the use of low-dose oral minoxidil (LDOM) for the treatment of hair loss is the potential risk of systemic adverse effects."1.62Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients. ( Bhoyrul, B; Hermosa-Gelbard, A; Jaén-Olasolo, P; Jerjen, R; Jimenez-Cauhe, J; John, JM; Koh, WL; Lo-Sicco, K; Moreno-Arrones, ÓM; Piraccini, BM; Pirmez, R; Poa, JE; Rodrigues-Barata, R; Rudnicka, L; Saceda-Corralo, D; Salas-Callo, CI; Shapiro, J; Sinclair, R; Starace, M; Tosti, A; Trindade de Carvalho, L; Vañó-Galván, S; Vincenzi, C; Waskiel-Burnat, A; Yin, L; Zamorano, JL, 2021)
"Minoxidil is a strong vasodilator used first in the 1970s for severe hypertension."1.37[Minoxidil intoxication, the pharmacological agent of a hair lotion]. ( Aprahamian, A; Chéron, G; Escoda, S; Merckx, A; Patteau, G, 2011)
"Minoxidil-treated pigs had tachycardia and hypotension and were killed 24 hr after the second dose."1.27Cardiac morphologic alterations in acute minoxidil cardiotoxicity in miniature swine. ( Ferrans, VJ; Herman, EH; Van Vleet, JF, 1984)
"Propranolol was demonstrated to block hydralazine-induced increases in serum renin activity in genetically hypertensive rats."1.25Altered renin release and propranolol potentiation of vasodilatory drug hypotension. ( Keeton, K; Pettinger, WA, 1975)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-199011 (64.71)18.7374
1990's1 (5.88)18.2507
2000's0 (0.00)29.6817
2010's3 (17.65)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Vañó-Galván, S2
Trindade de Carvalho, L2
Saceda-Corralo, D2
Rodrigues-Barata, R2
Kerkemeyer, KL1
Sinclair, RD1
Hermosa-Gelbard, Á2
Moreno-Arrones, ÓM2
Jimenez-Cauhe, J2
Bhoyrul, B2
Pirmez, R1
Koh, WL1
Poa, JE1
Jerjen, R1
John, JM1
Salas-Callo, CI1
Vincenzi, C1
Yin, L1
Lo-Sicco, K1
Waskiel-Burnat, A1
Starace, M1
Zamorano, JL1
Jaén-Olasolo, P1
Piraccini, BM1
Rudnicka, L1
Shapiro, J1
Tosti, A1
Sinclair, R1
Jordan, TJM1
Yaxley, PE1
Culler, CA1
Balakrishnan, A1
Cohn, JN1
McInnes, GT1
Shepherd, AM1
Aprahamian, A1
Escoda, S1
Patteau, G1
Merckx, A1
Chéron, G1
Hall, D1
Froer, KL1
Rudolph, W1
Van Vleet, JF1
Herman, EH2
Ferrans, VJ2
Cotorruelo, JG1
Llamazares, C1
Flórez, J1
Golterman-Hardenberg, JC1
Sobota, JT1
Martin, WB1
Carlson, RG1
Feenstra, ES1
Höffler, D1
Demers, HG1
Pettinger, WA1
Keeton, K1
Balazs, T1
Young, R1
Earl, FL1
Krop, S1
Werning, C1
Kleiner, JP1
Ball, JH1
Nelson, WP1
Norton, JD1
Mehta, PK1
Mamdani, B1
Shansky, RM1
Mahurkar, SD1
Dunea, G1
Dogterom, P1
Zbinden, G1
Reznik, GK1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Randomised, Crossover Bioavailability Clinical Trial of Oral Minoxidil 1 MG, After Single and Multiple Dose Administration to Healthy Volunteers Under Fasting Conditions.[NCT06015516]Phase 114 participants (Anticipated)Interventional2024-02-29Not yet recruiting
International Phase III, Multi Center, Randomized, Double Blind, Placebo and Active Controlled and Parallel Group Clinical Trial to Evaluate the Efficacy and Safety of Oral Minoxidil 1 mg in Female Patients With Androgenetic Alopecia[NCT05888922]Phase 3520 participants (Anticipated)Interventional2024-03-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for minoxidil and Tachycardia

ArticleYear
Direct-acting vasodilators.
    Journal of clinical hypertension (Greenwich, Conn.), 2011, Volume: 13, Issue:9

    Topics: Antihypertensive Agents; Hirsutism; Humans; Hydralazine; Hypertension; Minoxidil; Tachycardia; Treat

2011
Cardiotoxicity of vasodilators and positive inotropic/vasodilating drugs in dogs: an overview.
    Critical reviews in toxicology, 1992, Volume: 22, Issue:3-4

    Topics: Amines; Animals; Animals, Laboratory; Coronary Disease; Dogs; Humans; Minoxidil; Myocardium; Necrosi

1992

Trials

1 trial available for minoxidil and Tachycardia

ArticleYear
The effect of minoxidil on blood pressure and plasma renin activity in patients with essential and renal hypertension.
    Klinische Wochenschrift, 1976, Aug-01, Volume: 54, Issue:15

    Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Edema; Female; Humans; Hypertension; Hyperten

1976

Other Studies

14 other studies available for minoxidil and Tachycardia

ArticleYear
Oral minoxidil improves background hair thickness in lichen planopilaris.
    Journal of the American Academy of Dermatology, 2021, Volume: 84, Issue:6

    Topics: Administration, Oral; Adult; Aged; Alopecia; Female; Hair; Humans; Hypertrichosis; Hypotension, Orth

2021
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
    Journal of the American Academy of Dermatology, 2021, Volume: 84, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Alopecia; Child; Dizziness; Edema;

2021
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
    Journal of the American Academy of Dermatology, 2021, Volume: 84, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Alopecia; Child; Dizziness; Edema;

2021
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
    Journal of the American Academy of Dermatology, 2021, Volume: 84, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Alopecia; Child; Dizziness; Edema;

2021
Safety of low-dose oral minoxidil for hair loss: A multicenter study of 1404 patients.
    Journal of the American Academy of Dermatology, 2021, Volume: 84, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Alopecia; Child; Dizziness; Edema;

2021
Successful management of minoxidil toxicosis in a dog.
    Journal of the American Veterinary Medical Association, 2018, Jan-15, Volume: 252, Issue:2

    Topics: Animals; Dog Diseases; Dogs; Dopamine; Emulsions; Heart Rate; Hypotension; Minoxidil; Phospholipids;

2018
[Minoxidil intoxication, the pharmacological agent of a hair lotion].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2011, Volume: 18, Issue:12

    Topics: Child, Preschool; Female; Hair Preparations; Humans; Hypotension; Minoxidil; Monitoring, Physiologic

2011
Serial electrocardiographic changes during long-term treatment of severe hypertension with minoxidil.
    Journal of cardiovascular pharmacology, 1980, Volume: 2 Suppl 2

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Child; Child, Preschool; Coron

1980
Cardiac morphologic alterations in acute minoxidil cardiotoxicity in miniature swine.
    Experimental and molecular pathology, 1984, Volume: 41, Issue:1

    Topics: Animals; Arterioles; Coronary Vessels; Dogs; Endothelium; Heart Atria; Heart Diseases; Hemorrhage; H

1984
Minoxidil in severe and moderately severe hypertension, in association with methyldopa and chlortalidone.
    Angiology, 1982, Volume: 33, Issue:11

    Topics: Adult; Aged; Body Water; Chlorthalidone; Creatinine; Drug Therapy, Combination; Heart Rate; Humans;

1982
Experiences with the antihypertensive drug minoxidil.
    The Netherlands journal of medicine, 1980, Volume: 23, Issue:1

    Topics: Adult; Aged; Blood Pressure; Edema; Evaluation Studies as Topic; Female; Heart; Hirsutism; Humans; H

1980
Minoxidil: right atrial cardiac pathology in animals and in man.
    Circulation, 1980, Volume: 62, Issue:2

    Topics: Adult; Aged; Animals; Dogs; Female; Heart Atria; Heart Failure; Humans; Hypertension; Kidney Failure

1980
[Minoxidil in the treatment of malignant hypertension (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1977, Dec-02, Volume: 102, Issue:48

    Topics: Adrenergic beta-Antagonists; Adult; Blood Pressure; Drug Therapy, Combination; Female; Humans; Hyper

1977
Altered renin release and propranolol potentiation of vasodilatory drug hypotension.
    The Journal of clinical investigation, 1975, Volume: 55, Issue:2

    Topics: Angiotensin II; Animals; Blood Pressure; Central Nervous System; Depression, Chemical; Dose-Response

1975
Acute cardiomyopathy induced by the vasodilating antihypertensive agent minoxidil.
    Toxicology and applied pharmacology, 1979, Mar-15, Volume: 47, Issue:3

    Topics: Anesthesia; Animals; Arteritis; Cardiomyopathies; Coronary Vessels; Dogs; Hemorrhage; Hypotension; M

1979
The outpatient treatment of refractory hypertension with minoxidil.
    Southern medical journal, 1977, Volume: 70, Issue:7

    Topics: Adult; Ambulatory Care; Antihypertensive Agents; Body Fluids; Colorado; Female; Furosemide; Hirsutis

1977
Severe hypertension. Treatment with minoxidil.
    JAMA, 1975, Jul-21, Volume: 233, Issue:3

    Topics: Adult; Black People; Drug Evaluation; Edema; Female; Follow-Up Studies; Guanethidine; Humans; Hypert

1975