minoxidil has been researched along with Glioblastoma in 2 studies
Minoxidil: A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
minoxidil : A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study, we investigated whether, intravenously administered, ATP-sensitive potassium channel (K(ATP)) activator (minoxidil sulfate; MS) increases temozolomide and Herceptin delivery to brain tumors to induce anti-tumor activity and increase survival in nude mice with Glioblastoma multiforme (GBM) cells." | 3.75 | Activation of KATP channels increases anticancer drug delivery to brain tumors and survival. ( Khaitan, D; Meister, EA; Ningaraj, NS; Sankpal, UT; Vats, T, 2009) |
| "The expression of potassium channels in brain tumors is variable, which may be associated with different tumor permeability to therapeutic agents among patients." | 2.73 | Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models. ( Bayan, JA; Black, KL; Espinoza, AJ; Hu, J; Irvin, D; Ko, MK; Konda, BM; Ong, JM; Sacapano, MR; Shu, Y; Wang, X; Yin, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Black, KL | 1 |
| Yin, D | 1 |
| Konda, BM | 1 |
| Wang, X | 1 |
| Hu, J | 1 |
| Ko, MK | 1 |
| Bayan, JA | 1 |
| Sacapano, MR | 1 |
| Espinoza, AJ | 1 |
| Ong, JM | 1 |
| Irvin, D | 1 |
| Shu, Y | 1 |
| Ningaraj, NS | 1 |
| Sankpal, UT | 1 |
| Khaitan, D | 1 |
| Meister, EA | 1 |
| Vats, T | 1 |
1 trial available for minoxidil and Glioblastoma
| Article | Year |
|---|---|
Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models.
Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Capillary Permeabi | 2008 |
1 other study available for minoxidil and Glioblastoma
| Article | Year |
|---|---|
Activation of KATP channels increases anticancer drug delivery to brain tumors and survival.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineopl | 2009 |