minoxidil has been researched along with Cardiac Hypertrophy in 34 studies
Minoxidil: A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
minoxidil : A pyrimidine N-oxide that is pyrimidine-2,4-diamine 3-oxide substituted by a piperidin-1-yl group at position 6.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The open, long-term antihypertensive, hemodynamic and metabolic effects of betaxolol in combination with furosemide and minoxidil were investigated on 30 male patients with moderate to severe essential hypertension." | 9.07 | Cardiac changes from beta-blocker, diuretic and minoxidil combination in hypertension. ( Berlin, L; Chrysant, C; Chrysant, SG; Sadeghi, M, 1991) |
| "Minoxidil has been administered to 16 patients with severe hypertension and renal failure." | 9.04 | Minoxidil in severe hypertension. ( Mäkelä, M; Oka, M, 1978) |
| "In the present study, we evaluated the effects of blockade of the RAS by the angiotensin-converting enzyme inhibitor enalapril and the angiotensin II receptor blocker losartan on left ventricular (LV) and right ventricular mass and LV dilation in relation to changes in central hemodynamics during the maintenance of minoxidil and aortocaval shunt-induced cardiac hypertrophy." | 7.69 | Effects of enalapril versus losartan on regression of volume overload-induced cardiac hypertrophy in rats. ( Leenen, FH; Ruzicka, M; Yuan, B, 1994) |
| " To evaluate the possible involvement of the RAS in the development of minoxidil-induced cardiac hypertrophy, we assessed in normotensive rats minoxidil-induced changes in cardiac and plasma renin activity (PRA) and the potential of chronic treatment with the angiotensin-converting enzyme (ACE) inhibitor enalapril and the nonpeptide angiotensin II receptor blocker losartan to prevent minoxidil-induced cardiac hypertrophy." | 7.68 | Renin-angiotensin system and minoxidil-induced cardiac hypertrophy in rats. ( Leenen, FH; Ruzicka, M, 1993) |
| "The effects of long-term treatment with verapamil on blood pressure, cardiac hypertrophy and collagen content, collagen concentration and prolyl hydroxylase activity were studied in spontaneously hypertensive rats (SHR)." | 7.67 | Effects of long-term verapamil treatment on blood pressure, cardiac hypertrophy and collagen metabolism in spontaneously hypertensive rats. ( Ruskoaho, HJ; Savolainen, ER, 1985) |
| "Evidence of cardiac hypertrophy was slow to resolve despite good control of blood pressure." | 6.64 | Double-blind comparison of minoxidil and hydrallazine in severe hypertension. ( Bennett, CM; Connor, G; Wilburn, RL, 1976) |
| "Minoxidil treatment (120 and 200 mg/l) significantly increased left ventricular dry weight normalized for body weight by 19 +/- 4 and 24 +/- 4%, respectively." | 5.30 | Minoxidil-induced cardiac hypertrophy in guinea pigs. ( Borgdorff, P; Stienen, GJ; van der Velden, J, 1999) |
| "The mechanism of minoxidil-induced cardiac hypertrophy and its consequences for the myocardium have not been determined." | 5.29 | Structural and functional consequences of minoxidil-induced cardiac hypertrophy. ( Cifani, JR; Khairallah, PA; Milovanovic, M; Moravec, CS; Ruhe, T, 1994) |
| "quinapril, and six dogs treated with 8 mg/kg q." | 5.28 | Quinapril, an angiotensin converting enzyme inhibitor, prevents cardiac hypertrophy during episodic hypertension. ( Brant, D; Julius, S; Krause, L; Li, Y; Taylor, D, 1991) |
| "The open, long-term antihypertensive, hemodynamic and metabolic effects of betaxolol in combination with furosemide and minoxidil were investigated on 30 male patients with moderate to severe essential hypertension." | 5.07 | Cardiac changes from beta-blocker, diuretic and minoxidil combination in hypertension. ( Berlin, L; Chrysant, C; Chrysant, SG; Sadeghi, M, 1991) |
| "In a double-blind 6 month trial, the cardiac effects of captopril and minoxidil, administered as third step treatments, were compared in 34 men with essential hypertension and diastolic blood pressure greater than 95 mm Hg who were taking 200 mg/day of metoprolol and 80 mg/day of furosemide." | 5.06 | Effects of captopril and minoxidil on left ventricular hypertrophy in resistant hypertensive patients: a 6 month double-blind comparison. ( Chatellier, G; Corvol, P; Dufloux, MA; Julien, J; Menard, D; Menard, J; Plouin, PF; Prasquier, R, 1990) |
| "A randomised double blind study was performed in order to compare the cardiac effects of captopril and minoxidil in a subset of patients with severe primitive hypertension, uncontrolled (diastolic BP greater than 100 mmHg) by Metroprolol 200 mg/d and Furosemide 80 mg/d." | 5.06 | [Comparison of the effect of captopril and minoxidil on left ventricular mass. Results of a 6-month comparative double-blind test]. ( Chatellier, G; Corvol, P; Dufloux, MA; Ménard, D; Ménard, J; Plouin, PF; Prasquier, R, 1987) |
| "Minoxidil has been administered to 16 patients with severe hypertension and renal failure." | 5.04 | Minoxidil in severe hypertension. ( Mäkelä, M; Oka, M, 1978) |
| "In the present study, we evaluated the effects of blockade of the RAS by the angiotensin-converting enzyme inhibitor enalapril and the angiotensin II receptor blocker losartan on left ventricular (LV) and right ventricular mass and LV dilation in relation to changes in central hemodynamics during the maintenance of minoxidil and aortocaval shunt-induced cardiac hypertrophy." | 3.69 | Effects of enalapril versus losartan on regression of volume overload-induced cardiac hypertrophy in rats. ( Leenen, FH; Ruzicka, M; Yuan, B, 1994) |
| " This conclusion is strengthened by the observation that hypertrophic hearts from volume-overloaded rats had similar amounts of cardiac hypertrophy to the hearts from the hypertensive rats, without a change in flow, coronary vascular resistance or ischaemic sensitivity, whereas the hearts from isoproterenol-treated rats had lower ischaemic sensitivity and coronary vascular resistance." | 3.69 | Sensitivity to ischaemic ATP breakdown in different models of cardiac hypertrophy in rats. ( Harmsen, E; Leenen, FH; Ruzicka, M; Schoemaker, R; Yu, J, 1994) |
| " To evaluate the possible involvement of the RAS in the development of minoxidil-induced cardiac hypertrophy, we assessed in normotensive rats minoxidil-induced changes in cardiac and plasma renin activity (PRA) and the potential of chronic treatment with the angiotensin-converting enzyme (ACE) inhibitor enalapril and the nonpeptide angiotensin II receptor blocker losartan to prevent minoxidil-induced cardiac hypertrophy." | 3.68 | Renin-angiotensin system and minoxidil-induced cardiac hypertrophy in rats. ( Leenen, FH; Ruzicka, M, 1993) |
| "In this study, we determined whether the persistency of cardiac hypertrophy after chronic vasodilation therapy with minoxidil (minox) was associated with functional or metabolic alterations in hypertensive rat hearts before, during and after an ischemic insult." | 3.68 | [Effect of long-term administration of vasodilators and "antitrophic" agents on the structure and function of the heart in hypertensive rats]. ( Carlier, P; Gilles, R; Rorive, G; Smelten, N, 1990) |
| "To assess a possible involvement of cardiac volume overload in the development of cardiac hypertrophy during chronic arterial vasodilator treatment, changes in indexes of cardiac volume load in relation to changes in cardiac anatomy were evaluated during treatment of normotensive rats with 120 mg/l hydralazine or 120 mg/l minoxidil, with drinking water." | 3.67 | Arterial vasodilators, cardiac volume load, and cardiac hypertrophy in normotensive rats. ( Leenen, FH; Tsoporis, J; Yuan, BX, 1989) |
| "The effects of long-term treatment with verapamil on blood pressure, cardiac hypertrophy and collagen content, collagen concentration and prolyl hydroxylase activity were studied in spontaneously hypertensive rats (SHR)." | 3.67 | Effects of long-term verapamil treatment on blood pressure, cardiac hypertrophy and collagen metabolism in spontaneously hypertensive rats. ( Ruskoaho, HJ; Savolainen, ER, 1985) |
| "Evidence of cardiac hypertrophy was slow to resolve despite good control of blood pressure." | 2.64 | Double-blind comparison of minoxidil and hydrallazine in severe hypertension. ( Bennett, CM; Connor, G; Wilburn, RL, 1976) |
| " This is a significant limitation because sustained changes in blood pressure are often accompanied by changes in heart rate and together can lead to cardiac hypertrophy and myocardial degeneration in animals, and major adverse cardiovascular events (MACE) in humans." | 1.43 | Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight. ( Engle, SK; Watson, DE, 2016) |
| "Minoxidil treatment (120 and 200 mg/l) significantly increased left ventricular dry weight normalized for body weight by 19 +/- 4 and 24 +/- 4%, respectively." | 1.30 | Minoxidil-induced cardiac hypertrophy in guinea pigs. ( Borgdorff, P; Stienen, GJ; van der Velden, J, 1999) |
| "The mechanism of minoxidil-induced cardiac hypertrophy and its consequences for the myocardium have not been determined." | 1.29 | Structural and functional consequences of minoxidil-induced cardiac hypertrophy. ( Cifani, JR; Khairallah, PA; Milovanovic, M; Moravec, CS; Ruhe, T, 1994) |
| "quinapril, and six dogs treated with 8 mg/kg q." | 1.28 | Quinapril, an angiotensin converting enzyme inhibitor, prevents cardiac hypertrophy during episodic hypertension. ( Brant, D; Julius, S; Krause, L; Li, Y; Taylor, D, 1991) |
| "Minoxidil treatment for 8 weeks in both strains resulted in a decrease in mean arterial pressure and increases in ventricular weight to body weight ratios, plasma IR-ANP concentrations (in WKY from 133 +/- 20 to 281 +/- 34 pg ml-1, P less than 0." | 1.28 | Release of atrial natriuretic peptide from rat myocardium in vitro: effect of minoxidil-induced hypertrophy. ( Kinnunen, P; Leppäluoto, J; Ruskoaho, H; Taskinen, T, 1990) |
| "Treatment with hydralazine did not affect left ventricular weight and caused a small increase in the weight of the right ventricle." | 1.27 | Effects of arterial vasodilators on cardiac hypertrophy and sympathetic activity in rats. ( Leenen, FH; Tsoporis, J, 1988) |
| "Renal function and salt and water turnover were studied in SHR during acute and chronic administration of felodipine, which is an efficient antihypertensive vasodilating Ca2+ antagonist." | 1.27 | Renal and cardiovascular effects of acute and chronic administration of felodipine to SHR. ( Di Bona, GF; Ljung, B; Nordlander, M; Thorén, P; Yao, T, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (44.12) | 18.7374 |
| 1990's | 16 (47.06) | 18.2507 |
| 2000's | 1 (2.94) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Ohko, K | 1 |
| Nakajima, K | 1 |
| Nakajima, H | 1 |
| Hiraki, Y | 1 |
| Kubota, K | 1 |
| Fukao, T | 1 |
| Miyatake, S | 1 |
| Matsumoto, N | 1 |
| Sano, S | 1 |
| Engle, SK | 1 |
| Watson, DE | 1 |
| Ruskoaho, H | 3 |
| Ruzicka, M | 3 |
| Yuan, B | 3 |
| Leenen, FH | 12 |
| Tsoporis, J | 5 |
| Fields, N | 3 |
| Lee, RM | 3 |
| Harmsen, E | 1 |
| Schoemaker, R | 1 |
| Yu, J | 1 |
| Moravec, CS | 1 |
| Ruhe, T | 1 |
| Cifani, JR | 1 |
| Milovanovic, M | 1 |
| Khairallah, PA | 1 |
| van der Velden, J | 1 |
| Borgdorff, P | 1 |
| Stienen, GJ | 1 |
| Oka, M | 1 |
| Mäkelä, M | 1 |
| Connor, G | 1 |
| Wilburn, RL | 1 |
| Bennett, CM | 1 |
| Sen, S | 1 |
| Tarazi, RC | 1 |
| Bumpus, FM | 1 |
| Svahn, DS | 1 |
| Markenson, JA | 1 |
| Sherman, RL | 1 |
| Chrysant, SG | 1 |
| Chrysant, C | 1 |
| Sadeghi, M | 1 |
| Berlin, L | 1 |
| Julius, S | 1 |
| Li, Y | 1 |
| Brant, D | 1 |
| Krause, L | 1 |
| Taylor, D | 1 |
| Julien, J | 1 |
| Dufloux, MA | 2 |
| Prasquier, R | 2 |
| Chatellier, G | 2 |
| Menard, D | 2 |
| Plouin, PF | 2 |
| Menard, J | 2 |
| Corvol, P | 2 |
| Cody, RJ | 1 |
| Kinnunen, P | 1 |
| Taskinen, T | 1 |
| Leppäluoto, J | 2 |
| Carlier, P | 1 |
| Smelten, N | 1 |
| Gilles, R | 1 |
| Rorive, G | 1 |
| Stasch, JP | 1 |
| Kazda, S | 1 |
| Hirth-Dietrich, C | 1 |
| Neuser, D | 1 |
| Yuan, BX | 1 |
| Prowse, S | 1 |
| Nordlander, M | 1 |
| Di Bona, GF | 1 |
| Ljung, B | 1 |
| Yao, T | 1 |
| Thorén, P | 1 |
| Ruskoaho, HJ | 1 |
| Savolainen, ER | 1 |
| Fenje, P | 1 |
| Pettinger, WA | 1 |
| Mitchell, HC | 1 |
5 trials available for minoxidil and Cardiac Hypertrophy
| Article | Year |
|---|---|
Minoxidil in severe hypertension.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Cardiac Output; Cardiomegaly; Clinical Trials as Top | 1978 |
Double-blind comparison of minoxidil and hydrallazine in severe hypertension.
Topics: Adult; Aged; Cardiomegaly; Creatinine; Female; Humans; Hydralazine; Hypertension; Male; Middle Aged; | 1976 |
Cardiac changes from beta-blocker, diuretic and minoxidil combination in hypertension.
Topics: Betaxolol; Cardiomegaly; Drug Therapy, Combination; Edema; Furosemide; Humans; Hypertension; Male; M | 1991 |
Effects of captopril and minoxidil on left ventricular hypertrophy in resistant hypertensive patients: a 6 month double-blind comparison.
Topics: Adult; Aged; Aldosterone; Captopril; Cardiomegaly; Double-Blind Method; Echocardiography; Humans; Hy | 1990 |
[Comparison of the effect of captopril and minoxidil on left ventricular mass. Results of a 6-month comparative double-blind test].
Topics: Adult; Captopril; Cardiomegaly; Double-Blind Method; Drug Administration Schedule; Humans; Hypertens | 1987 |
29 other studies available for minoxidil and Cardiac Hypertrophy
| Article | Year |
|---|---|
Skin and hair abnormalities of Cantu syndrome: A congenital hypertrichosis due to a genetic alteration mimicking the pharmacological effect of minoxidil.
Topics: Antihypertensive Agents; Biopsy; Cardiomegaly; Child; Child, Preschool; Female; Hair Follicle; Hirsu | 2020 |
Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight.
Topics: Animals; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cardiomegaly; Heart Rate; Indoles; M | 2016 |
Prevention of cardiac hypertrophy by long-term treatment with isosorbide dinitrate and prazosin but not by minoxidil in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cardiomegaly; Female; Hypertension; Isosorbide Dinitrate; Male; Minoxidil; | 1984 |
Effects of enalapril versus losartan on regression of volume overload-induced cardiac hypertrophy in rats.
Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Volume; Body Weight; Cardiomegaly; Coron | 1994 |
Effects of the arterial vasodilator minoxidil on cardiovascular structure and sympathetic activity in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Blood Volume; Cardiomegaly; Heart; Heart Ventricles; Hydrochlorothiazide; H | 1993 |
Sensitivity to ischaemic ATP breakdown in different models of cardiac hypertrophy in rats.
Topics: Adenosine Triphosphate; Animals; Cardiomegaly; Coronary Circulation; Hyperemia; Hypertension; Isopro | 1994 |
Structural and functional consequences of minoxidil-induced cardiac hypertrophy.
Topics: Animals; Body Weight; Cardiomegaly; Heart; Male; Minoxidil; Myocardial Contraction; Myocardium; Papi | 1994 |
Renin-angiotensin system and minoxidil-induced cardiac hypertrophy in rats.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Enalapril; Heart; Hemodyn | 1993 |
Minoxidil-induced cardiac hypertrophy in guinea pigs.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardiomegaly; Contractile Proteins; Female; Guinea Pigs; H | 1999 |
Mortality after coronary artery occlusion in different models of cardiac hypertrophy in rats.
Topics: Animals; Arteriovenous Shunt, Surgical; Blood Pressure; Cardiomegaly; Coronary Disease; Coronary Ves | 2001 |
Cardiac hypertrophy and antihypertensive therapy.
Topics: Animals; Cardiomegaly; DNA; Hydroxyproline; Hypertension; Male; Methyldopa; Minoxidil; Myocardium; P | 1977 |
Minoxidil and cardiac enlargement.
Topics: Cardiomegaly; Humans; Hypertension; Minoxidil; Pericardial Effusion; Pyrimidines | 1978 |
Renal involvement in progressive systemic sclerosis: prolonged survival with aggressive antihypertensive management.
Topics: Adult; Antihypertensive Agents; Cardiomegaly; Digoxin; Drug Therapy, Combination; Female; Furosemide | 1979 |
Chronic arterial vasodilation, central hemodynamics, and cardiac hypertrophy in spontaneously hypertensive rats.
Topics: Animals; Arteries; Blood Pressure; Body Weight; Cardiac Output; Cardiomegaly; Drinking; Heart Rate; | 1992 |
Opposite effects of arterial vasodilators on cardiac vs. arterial hypertrophy and sympathetic activity in spontaneously hypertensive rats.
Topics: Animals; Cardiomegaly; Heart; Hemodynamics; Male; Mesenteric Arteries; Minoxidil; Norepinephrine; Ra | 1991 |
Quinapril, an angiotensin converting enzyme inhibitor, prevents cardiac hypertrophy during episodic hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cardiomegaly; Dogs; Endocardium; | 1991 |
Arterial vasodilation and cardiovascular structural changes in normotensive rats.
Topics: Animals; Arteries; Blood Volume; Cardiomegaly; Cardiovascular Physiological Phenomena; Cardiovascula | 1991 |
Regression of left ventricular hypertrophy in resistant hypertension.
Topics: Captopril; Cardiomegaly; Humans; Hypertension; Minoxidil | 1990 |
Release of atrial natriuretic peptide from rat myocardium in vitro: effect of minoxidil-induced hypertrophy.
Topics: Animals; Atrial Natriuretic Factor; Body Weight; Cardiomegaly; Hemodynamics; In Vitro Techniques; Ki | 1990 |
[Effect of long-term administration of vasodilators and "antitrophic" agents on the structure and function of the heart in hypertensive rats].
Topics: Animals; Cardiomegaly; Drug Therapy, Combination; Eflornithine; Heart Ventricles; Hemodynamics; Hype | 1990 |
Effects of nisoldipine on atrial natriuretic peptides, blood pressure and cardiac hypertrophy in Dahl rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Cardiomegaly; Male; Minoxidil; Nisoldipine; Rats | 1990 |
Arterial vasodilators, cardiac volume load, and cardiac hypertrophy in normotensive rats.
Topics: Animals; Arteries; Blood Pressure; Blood Volume; Cardiomegaly; Heart Rate; Heart Ventricles; Hydrala | 1989 |
Time-course of changes in cardiac hypertrophy and pressor mechanisms in two-kidney, one clip hypertensive rats during treatment with minoxidil, enalapril or after uninephrectomy.
Topics: Animals; Blood Pressure; Blood Volume; Cardiac Volume; Cardiomegaly; Catecholamines; Enalapril; Hear | 1987 |
Effects of arterial vasodilators on cardiac hypertrophy and sympathetic activity in rats.
Topics: Animals; Blood Pressure; Blood Volume; Body Weight; Cardiomegaly; Epinephrine; Heart; Heart Rate; He | 1988 |
Renal and cardiovascular effects of acute and chronic administration of felodipine to SHR.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Felodipine; Furosemide; Heart Rate; | 1985 |
Immunoreactive atrial natriuretic peptide in ventricles, atria, hypothalamus, and plasma of genetically hypertensive rats.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Cardiomegaly; Heart Rate; Hypertens | 1988 |
Effects of long-term verapamil treatment on blood pressure, cardiac hypertrophy and collagen metabolism in spontaneously hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Cardiomegaly; Collagen; Female; Heart; Hydroxyproline; Hypertension; | 1985 |
Effects of minoxidil on blood pressure and cardiac hypertrophy in two-kidney, one-clip hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Drinking; Hypertension, Renal; Male; Minoxidil; | 1985 |
Minoxidil--an alternative to nephrectomy for refractory hypertension.
Topics: Adult; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Cardiomegaly; Diuretics; Elect | 1973 |