minocycline and Urinary-Bladder-Neoplasms

Topics: Holoprosencephaly; Humans; Minocycline; Umbilicus; Urinary Bladder Neoplasms

Topics: Aged; Anti-Bacterial Agents; Carcinoma, Transitional Cell; Cross Infection; Drug Resistance, Multiple; Emphysema; Gram-Negative Bacterial Infections; Humans; Lupus Erythematosus, Discoid; Male; Minocycline; Obesity; Pneumonia, Bacterial; Pulmonary Disease, Chronic Obstructive; Stenotrophomonas maltophilia; Tigecycline; Urinary Bladder Neoplasms

Bladder cancers have different angiogenic pathways distinguishing not only papillary from solid tumours, but even papillary superficial from papillary invasive ones, thus representing selective targets for antiangiogenic drugs.. The bacterial wall component tecogalan, inhibiting basic fibroblast growth factor (bFGF), the fumagillin derivative TNP-470, inhibiting vascular endothelial growth factor (VEGF), the distamycin A derivative PNU153429, and the tetracycline minocycline were administered to nude mice injected with the human bladder cancer cell lines 639V, causing bFGF-expressing papillary superficial tumours, or T24, causing VEGF-expressing papillary invasive tumours.. Tecogalan had no effect even on 639V tumour growth, where bFGF was unaffected. TNP-470 only had an effect on T24 tumours, delaying tumour appearance and growth and lowering VEGF; these effects were augmented by adding minocycline. PNU153429 had no effect on 639V tumours, and a slight effect on T24 tumours.. TNP-470 may represent a selective drug for the treatment of VEGF-expressing invasive papillary bladder tumours.

Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Papillary; Cell Line, Tumor; Cyclohexanes; Distamycins; Female; Fibroblast Growth Factor 2; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Minocycline; O-(Chloroacetylcarbamoyl)fumagillol; Polysaccharides, Bacterial; PPAR gamma; Sesquiterpenes; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A