minocycline and Ulcer

Topics: Anti-Bacterial Agents; Antiretroviral Therapy, Highly Active; Community-Acquired Infections; Drug Resistance, Multiple, Bacterial; Electrophoresis, Gel, Pulsed-Field; Genes, Bacterial; HIV Infections; Homosexuality, Male; Humans; Japan; Male; Methicillin Resistance; Methicillin-Resistant Staphylococcus aureus; Middle Aged; Minocycline; Scrotum; Staphylococcal Infections; Treatment Outcome; Ulcer

To report a case of phthisis bulbi resulting from late congenital syphilis untreated until adulthood.. Observational case report.. We report clinical and laboratory evaluations of a 43-year-old woman who presented with a palpebral ulcer of the right eye.. The patient had a gummatous palpebral ulcer and a phthisis bulbi in the right eye and a gumma on the left eyelid. A silent interstitial keratitis of the left eye was detected. The patient had hearing loss in the right ear, her nose was missing, and her right leg had been amputated. Treponemal pallidum hemagglutination (TPHA) test was positive. Although we administered intensive oral penicillin, the clinical symptoms of the patient did not improve.. This is a rare case of phthisis bulbi resulting from late congenital syphilis. We emphasize that treatment for late congenital syphilis must be carried out early and completely.

Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Eyelid Diseases; Female; Glucocorticoids; Hemagglutination Tests; Humans; Keratitis; Minocycline; Syphilis Serodiagnosis; Syphilis, Congenital; Ulcer

Ten cases of tetracycline derivatives related drug induced esophageal ulceration were described. Five cases were due to minocycline and another five were due to doxycycline. Recumbent posture after drug ingestion was one of the predisposing factors. Odynophagia was the main symptom but may not be the presenting symptom. The diagnosis was easily confirmed by endoscopy. Single-contrast barium study was not sensitive for the demonstration of the esophageal ulcers. The recommended treatment includes cessation of the offending drug and symptomatic treatment. All recovered without any sequela within 3 to 11 days. The most important measure to prevent this condition is to instruct patients to take drugs in the upright position with at least 100 ml of water.

Topics: Adolescent; Adult; Doxycycline; Esophageal Diseases; Female; Humans; Male; Minocycline; Posture; Risk Factors; Ulcer

Topics: Administration, Oral; Adult; Esophageal Diseases; Humans; Male; Minocycline; Tetracyclines; Ulcer

Topics: Adolescent; Esophageal Diseases; Humans; Male; Minocycline; Tetracyclines; Ulcer