minocycline and Tooth-Fractures

Revascularization is a valuable treatment in immature necrotic teeth that allows the continuation of root development.. This article describes the successful revascularization treatment of an immature maxillary lateral incisor that was initially diagnosed with apical periodontitis. The tooth was asymptomatic and functional clinically and radiographically during the follow-up period of 5 years.. The follow-up showed evidence of progressive thickening of the dentinal walls, development of root length and apical closure. The article also discusses the currently available literature regarding revascularization of immature permanent teeth.

Topics: Anti-Bacterial Agents; Apexification; Calcium Hydroxide; Child; Ciprofloxacin; Dental Pulp Necrosis; Dental Restoration, Permanent; Dentin; Follow-Up Studies; Humans; Incisor; Male; Metronidazole; Minocycline; Neovascularization, Physiologic; Odontogenesis; Periapical Periodontitis; Root Canal Filling Materials; Root Canal Irrigants; Root Canal Preparation; Tooth Fractures; Tooth Root

To investigate the effect of medicaments used in endodontic regeneration on root fracture resistance and microhardness of radicular dentine.. The root canals of mandibular premolars (n = 180) were instrumented and randomized into three treatment groups and an untreated control group. Each treatment group received either triple antibiotic paste (TAP), double antibiotic paste (DAP) or calcium hydroxide paste [Ca(OH)₂] intracanal medicament. Teeth were kept in saline for 1 week, 1 month or 3 months. After each time-point, 15 teeth were randomly selected from each group and two root cylinders were obtained from each tooth. One cylinder was subjected to a fracture resistance test, and the other cylinder was used for a microhardness test. Two-way ANOVA and Tukey's pairwise comparisons were used for statistical analysis.. For the microhardness test, the two-way interaction between group and time was significant (P < 0.001). The intracanal application of TAP and DAP caused significant and continuous decrease in root dentine microhardness after one (P < 0.05) and 3 months (P < 0.001), respectively. The three-month intracanal application of Ca(OH)₂ significantly increased the microhardness of root dentine (P < 0.05). The time factor had a significant effect on fracture resistance (P < 0.001). The three intracanal medicaments caused significant decreases in fracture resistance ranging between 19% and 30% after 3-month application compared to 1-week application.. In this laboratory study, the 3-month application of triple antibiotic paste, double antibiotic paste or calcium hydroxide paste medicaments significantly reduced the root fracture resistance of extracted teeth compared to a 1-week application.

Topics: Anti-Bacterial Agents; Apexification; Bicuspid; Calcium Hydroxide; Ciprofloxacin; Dentin; Drug Combinations; Hardness; Humans; Materials Testing; Metronidazole; Microscopy, Electron, Scanning; Minocycline; Root Canal Irrigants; Root Canal Preparation; Smear Layer; Time Factors; Tooth Fractures; Tooth Root

The aim of this report is to describe a novel method of revascularization therapy done in a non-vital, immature permanent tooth using Platelet-rich fibrin (PRF),in a recently developed scaffold material to overcome limitations associated with the traditional method of revascularization using natural blood clot. PRF prepared from autologous blood was placed in the root canal and patient was followed up regularly at one, three, six, nine and 12 months for detailed clinical and radiographic evaluation. At 12 months, radiographic examination revealed root elongation, root end closure, continued thickening of the root dentinal walls, obliteration of root canal space, and normal periradicular anatomy. However, more long term prospective trials and histological studies are highly needed before to testify PRF a panacea for the regenerative endodontic therapy in children.

Topics: Anti-Bacterial Agents; Apexification; Blood Platelets; Child; Ciprofloxacin; Dental Pulp Cavity; Dental Pulp Necrosis; Dentin; Drug Combinations; Fibrin; Follow-Up Studies; Humans; Incisor; Male; Metronidazole; Minocycline; Root Canal Preparation; Tissue Scaffolds; Tooth Apex; Tooth Fractures; Tooth, Nonvital

This case report describes the treatment of a horizontal root fracture in a maxillary central incisor (tooth #8) using a triple antibiotic paste and mineral trioxide aggregate. A nonsurgical endodontic treatment was performed to a coronal root canal fragment of tooth #8. During the treatment procedure, 1% sodium hypochlorite solution was used for irrigation and a triple antibiotic paste was used as an intracanal medicament. The coronal part of the canal was obturated with mineral trioxide aggregate totally. At follow-up examination after 12 months, the tooth was asymptomatic and radiographically showed repair of the fracture region. Healing was achieved without any need for further interventions.

Topics: Aluminum Compounds; Anti-Bacterial Agents; Calcium Compounds; Chlorhexidine; Ciprofloxacin; Drug Combinations; Follow-Up Studies; Fracture Healing; Humans; Incisor; Male; Metronidazole; Minocycline; Oxides; Root Canal Filling Materials; Root Canal Irrigants; Root Canal Obturation; Silicates; Sodium Hypochlorite; Tooth Fractures; Tooth Root; Young Adult

Elimination of microbial contamination from the root canal system is a precondition for successful root canal treatment. In this regard, mechanical instrumentation, irrigation, and intracanal medication are all important. This case report assesses the efficacy of a triple antibiotic paste consisting of metronidazole, ciprofloxacin, and minocycline in the disinfection of immature teeth with apical periodontitis. An 8-year-old girl presented at the Department of Pediatric Dentistry for the evaluation of right and left maxillary central incisors with crown fractures and luxation. The right central incisor had a large periapical lesion, which was treated by filling the canal with a ciprofloxacin/metronidazole/minocycline paste. After 4 months, the patient had no symptoms, and a radiograph showed the radiolucency had completely resolved. At the 1-year follow-up, a periapical radiograph showed complete root development and apical closure. These results indicate that triple antibiotic paste is effective in disinfecting immature teeth with periapical lesions.

Topics: Anti-Infective Agents, Local; Child; Ciprofloxacin; Drug Combinations; Female; Humans; Incisor; Metronidazole; Minocycline; Periapical Periodontitis; Root Canal Irrigants; Tooth Crown; Tooth Fractures; Tooth Root; Treatment Outcome

Trauma to the teeth and supporting structures is a frequent problem among children. Endodontic treatment is necessary for 41.3% of traumatized teeth. Two of the most important criteria for successful endodontic treatment are the elimination of microorganisms and apical sealing. A combination of antibiotic drugs (metranidozole, ciprofloxacin, and minocycline) is used to eliminate target bacteria, which are possible sources of endodontic lesions. For cases in which apical sealing is difficult, specific materials to plug the apical region have been advocated. Mineral trioxide aggregate (MTA) has become the material of choice because it is biocompatible and has bacteriostatic action.. This case report describes the nonsurgical retreatment of a traumatized tooth that had already undergone unsuccessful apical resection associated with a large periradicular lesion. A combination of antibiotic drugs was used as an intracanal medicament, and MTA was used to obtain a hermetic seal of the lateral tooth that had undergone unsuccessful apical resection.. On follow up, the tooth was clinically and radiographically asymptomatic for 30 months.. The results of this case show that MTA and triple antibiotic paste can be used clinically in the treatment of an unsuccessfully resected tooth associated with a large periradicular lesion.

Topics: Aluminum Compounds; Anti-Bacterial Agents; Apicoectomy; Calcium Compounds; Child; Ciprofloxacin; Cuspid; Drug Combinations; Follow-Up Studies; Humans; Incisor; Male; Metronidazole; Minocycline; Oxides; Periapical Diseases; Retreatment; Root Canal Filling Materials; Root Canal Irrigants; Root Canal Obturation; Root Canal Preparation; Silicates; Tooth Fractures