minocycline and Thrombosis

We previously demonstrated that minocycline-EDTA was efficacious at preventing catheter-related bloodstream infections (BSIs) in three patients with recurrent infections. This study compared heparin with minocycline-EDTA as flush solutions used among dialysis patients with central venous catheters, a high-risk group for catheter-related BSI.. Patients were enrolled within 72 hours of catheter insertion and randomized to receive heparin or minocycline-EDTA as a flush after each dialysis session. Each syringe containing flush solution was wrapped in orange plastic to conceal the type of solution it contained. Patients were observed for evidence of infection and catheter thrombosis. After catheters were removed, cultures were performed to determine whether microbial colonization had occurred.. During a 14-month period, 60 patients were enrolled (30 in each group). The two groups had similar demographics and underlying diseases. Catheter survival at 90 days was 83% for the minocycline-EDTA group versus 66% for the heparin group (P = .07). Significant catheter colonization, a surrogate measure of catheter-related infection, was significantly more frequent in the heparin group (9 of 14 vs 1 of 11; P = .005). There was only one catheter-related bacteremia and it occurred in the heparin group.. When compared with heparin, minocycline-EDTA had a better 90-day catheter survival (P = .07) and a decreased rate of catheter colonization. This pilot study warrants a larger prospective, randomized trial.

Topics: Anti-Bacterial Agents; Anticoagulants; Catheterization, Central Venous; Catheters, Indwelling; Cross Infection; Double-Blind Method; Drug Combinations; Edetic Acid; Equipment Contamination; Female; Heparin; Humans; Infection Control; Male; Middle Aged; Minocycline; North Carolina; Pilot Projects; Prospective Studies; Renal Dialysis; Risk Factors; Sepsis; Survival Analysis; Therapeutic Irrigation; Thrombosis; Time Factors

In this prospective cohort study, minocycline-ethylenediaminetetraacetate (M-EDTA) was used as a lock solution in indwelling ports inserted in 14 children with cancer. No port infections, thrombotic events, or other adverse events were observed, compared with 10 port infections that occurred in 48 control patients whose ports were flushed with heparin. M-EDTA is a promising lock solution in long-term catheters.

Topics: Anti-Bacterial Agents; Catheters, Indwelling; Chelating Agents; Child; Child, Preschool; Cohort Studies; Drug Therapy, Combination; Edetic Acid; Female; Humans; Male; Minocycline; Neoplasms; Prospective Studies; Prosthesis-Related Infections; Thrombosis

A 55-year-old man treated with polycythemia vera visited our hospital, complaining of left abdominal pain and dyspnea. He had received minocycline infusions three weeks earlier for mycoplasma pneumonia. Contrast-enhanced computed tomography revealed pulmonary embolism and splenic infarction. Ultrasonography of the vein in the forearm revealed a thrombus filling the distal brachial veins to the radial veins on both sides. His condition improved after anticoagulant therapy, and right and left shunts were detected on transesophageal echocardiography. This suggested that thrombus in the forearm may have been the source of the embolism.

Topics: Humans; Male; Middle Aged; Minocycline; Polycythemia Vera; Pulmonary Embolism; Splenic Infarction; Thrombosis

Topics: Anti-Bacterial Agents; Bacteremia; Cardiovascular Diseases; Conscious Sedation; Crowns; Dental Implants; Dental Scaling; Gingivitis; Humans; Inflammation Mediators; Minocycline; Periodontitis; Probiotics; Risk Assessment; Thrombosis; Tooth Loss; United States