minocycline and Stomatitis--Aphthous

The aim of the study was to assess the efficacy of 2 different concentrations of minocycline mouthwashes on the symptoms of recurrent aphthous stomatitis (RAS).. The 2-year study was designed as a randomized, double-blind, crossover study. Healthy patients with frequent RAS episodes received 2 sealed and computer-randomized marked kits containing minocycline mouthwashes (0.2% and 0.5% solution). The patients were asked to use 1 of the kits on the first episode of RAS, starting with the first onset of prodromal symptoms, until the symptoms resolved or up to a maximum of 10 days (whichever came first). The patients were asked to use their second kit during a subsequent episode.. A total of 14 patients (8 males, 6 females) completed the 2 arms of the study. The mean intensity of pain was significantly lower when the 0.5% solution was used compared with the 0.2% solution (P = .027). The difference reached the level of statistical significance as soon as the end of the second day of use (P = .032). Only minor and temporary adverse reactions were documented.. We found that 0.5% minocycline mouth rinse was more effective than the 0.2% concentration, which had been suggested by our group in previous studies for the management of RAS.

Topics: Adult; Anti-Bacterial Agents; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Middle Aged; Minocycline; Mouthwashes; Recurrence; Stomatitis, Aphthous; Treatment Outcome

Recurrent aphthous stomatitis (RAS) is a common ulcerative condition of the oral mucosa. We assessed minocycline and tetracycline oral rinses in patients with frequent episodes of RAS in a clinical randomized crossover trial. Seventeen patients with high frequency recurrent minor RAS were randomly allocated to a cross-over topical therapy with 0.2 percent minocycline or 0.25 percent tetracycline aqueous solution mouthwash. The minimum interval between the cross-over was 30 days. The intensity of pain was recorded daily using a visual analogue scale. Minocycline mouthwashes as compared to topical tetracycline rinses resulted in significantly improved pain control, by reducing the severity and duration of pain. Topical minocycline rinse may be a potential treatment for other mucosal diseases that result in mucosal ulceration and pain.

Topics: Administration, Topical; Adolescent; Adult; Aged; Cross-Over Studies; Female; Humans; Male; Middle Aged; Minocycline; Mouth Mucosa; Mouthwashes; Pain Measurement; Patient Satisfaction; Recurrence; Risk Assessment; Severity of Illness Index; Stomatitis, Aphthous; Tetracycline; Treatment Outcome

Topics: Adult; Aged; Child, Preschool; Female; Humans; Male; Middle Aged; Minocycline; Mouthwashes; Recurrence; Stomatitis, Aphthous; Tetracyclines