minocycline and Sebaceous-Gland-Diseases

Sebaceous glands without a follicular structure are present in the eyelid margin (meibomian glands), lip, glans penis and vulva. Inflammatory disease of a sebaceous gland lacking follicles is rare, except for meibomitis. We report the first two cases of vulval sebaceous adenitis. Painful, yellowish-orange papules/nodules recurred at the vulval mucocutaneous junction or mucosa during the luteal phase of the menstrual cycle. Histopathologically, a dense neutrophilic infiltration was observed within the sebaceous ducts. In both cases, oral minocycline improved the condition. They had been treated with antiherpetic agents. It is possible that women diagnosed with recurrent genital herpes have genital neutrophilic sebaceous adenitis.

Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Dermoscopy; Female; Humans; Inflammation; Luteal Phase; Middle Aged; Minocycline; Neutrophils; Sebaceous Gland Diseases; Sebaceous Glands; Vulva