minocycline and Pyoderma

We report a rare case of black thyroid accompanied by papillary carcinoma in a patient with an extended history of minocycline treatment. A 78-year-old man was referred to our outpatient clinic with swelling in his neck. He had been taking minocycline for the previous 2 years and 7 months to treat chronic perianal pyoderma. Neck ultrasonography and computed tomography demonstrated a 3.5 × 3.7 × 5.0-cm nodule in the left thyroid lobe, and fine-needle aspiration cytology identified it as a papillary carcinoma. The patient underwent a total thyroidectomy and neck dissection. During the procedure, a distinct black discoloration of the thyroid parenchyma was observed. Histopathology confirmed both the black thyroid and the papillary carcinoma. Based on the thyroid gland's discoloration and the history of minocycline use, the patient was diagnosed with minocycline-induced black thyroid. He was symptom-free 20 months after surgery.

Topics: Aged; Anti-Bacterial Agents; Anus Diseases; Carcinoma; Carcinoma, Papillary; Humans; Male; Minocycline; Neck Dissection; Pigmentation Disorders; Pyoderma; Thyroid Cancer, Papillary; Thyroid Diseases; Thyroid Gland; Thyroid Neoplasms; Thyroidectomy; Treatment Outcome

Topics: Adult; Benzoyl Peroxide; Cheek; Erythromycin; Female; Granulomatosis, Orofacial; Humans; Metronidazole; Minocycline; Neutrophils; Pyoderma

Pyoderma faciale is an uncommon acute presentation of rosacea. Edema, nodules, and draining sinuses may occur. Women in their early 20s are typically affected, and severe scarring may result in untreated cases. We report the case of a woman in whom a biopsy helped establish an early diagnosis so that decisive intervention could be initiated and scarring avoided. The histologic features of pyoderma faciale only rarely have been described and are illustrated in this case.

Topics: Adult; Anti-Bacterial Agents; Biopsy; Diagnosis, Differential; Drug Therapy, Combination; Facial Dermatoses; Female; Humans; Minocycline; Prednisone; Pyoderma

Topics: Anti-Bacterial Agents; Breast; Female; Granuloma; Humans; Middle Aged; Minocycline; Pyoderma; Skin Ulcer

Superficial granulomatous pyoderma, recently described as a variant of pyoderma gangrenosum, would be better termed pathergic granulomatous cutaneous ulceration as the seven previously described cases, as well as our own two cases, have significant dermal involvement histologically and heal with scarring. In contrast to pyoderma gangrenosum, lesions of superficial granulomatous pyoderma respond to less toxic anti-inflammatory agents.

Topics: Adult; Chronic Disease; Dapsone; Diagnosis, Differential; Granuloma; Humans; Male; Minocycline; Pyoderma; Recurrence; Skin Ulcer

An 80-year-old Caucasian female with rheumatoid arthritis and recurrent atypical bullous pyoderma gangrenosum is described. There was no evidence of any underlying myeloproliferative disorder. Rapid healing occurred in response to oral minocycline hydrochloride and topical clobetasol propionate.

Topics: Administration, Cutaneous; Administration, Oral; Aged; Aged, 80 and over; Clobetasol; Female; Humans; Minocycline; Pyoderma; Recurrence; Skin Diseases, Vesiculobullous

Twenty-five patients had superficial ulcerative and vegetative pyoderma with granulomatous histologic findings. Healing occurred without systemic corticosteroid therapy in all but three patients. All patients had clinical pyoderma gangrenosum. In five patients the lesion occurred after surgery of the skin. Histopathologic study of 40 biopsy specimens showed focal neutrophilic abscesses of the papillary dermis, often with peripheral palisading histiocytes and foreign-body giant cells. Pseudoepitheliomatous, vegetative hyperplasia and sinus tract formation were observed frequently. All patient had massive areas of plasmacytosis, and 13 had eosinophils. Granulation tissue, hemorrhage, and fibrosis were additional features in some areas. Foreign material in the lesions was considered unimportant, except in one patient with a starch granuloma. Therapy with local corticosteroids, minocycline, tetracycline, or sulfa drugs resulted in healing in 15 patients. We believe that we have identified a localized, limited form of chronic superficial pyoderma gangrenosum with verrucous and ulcerative lesions and a granulomatous histologic appearance that represents a unique pattern of this disease in some patients.

Topics: Abscess; Adolescent; Adrenal Cortex Hormones; Adult; Aged; Child; Female; Gangrene; Granuloma; Humans; Male; Middle Aged; Minocycline; Pyoderma; Skin Ulcer

Blastomycosis-like pyoderma is an uncommon reaction pattern to a superficial bacterial infection in persons with a variety of predisposing conditions such as chronic ethanol use and poor nutrition. We are reporting a case that initially responded poorly to previously described treatment regimens but responded well to combination treatment with carbon dioxide laser debridement and long-term minocycline.

Topics: Blastomycosis; Combined Modality Therapy; Debridement; Female; Humans; Laser Therapy; Middle Aged; Minocycline; Pyoderma; Tetracyclines

The authors report one case of Pyoderma gangrenosum whose unusual cervical localization was particularly bothering. Besides, the patient, an 18-year-old girl, had clinical symptoms of Crohn's disease confirmed by radiological investigations and bowel pathology. A benign monoclonal gammapathy and an auto-immune haemolytic anaemia were also found. After four plasma exchanges Pyoderma healed rapidly, Crohn's disease stabilized and biological abnormalities disappeared. Comments and review of the literature are reported. It appears that such a case is quite exceptional, as far as clinical, biological data and therapy (plasma exchange) are concerned.

Topics: Adolescent; Crohn Disease; Female; Humans; Metronidazole; Minocycline; Plasma Exchange; Pyoderma; Skin Ulcer

Topics: Adult; Arthritis; Female; Humans; Minocycline; Pyoderma; Skin Ulcer; Tetracyclines

Pyoderma gangrenosum (PG) is a characteristic ulcerative condition of unknown etiology. Four cases are reported of patients with PG who responded to minocycline hydrochloride therapy. Possible mechanisms for this apparently efficacious modality are discussed.

Topics: Adult; Female; Humans; Male; Middle Aged; Minocycline; Pyoderma; Tetracyclines