minocycline and Pruritus

► Abdominal pain ► Lower-leg itching ► Dark urine & yellow eyes.

Topics: Abdominal Pain; Acne Vulgaris; Adolescent; Analgesics; Antipruritics; Chemical and Drug Induced Liver Injury; Female; Glucocorticoids; Humans; Immunologic Factors; Minocycline; Mycophenolic Acid; Prednisolone; Pruritus; Treatment Outcome; Urine; White People

Topics: Administration, Oral; Adolescent; Biopsy, Needle; Diagnosis, Differential; Female; Humans; Hyperpigmentation; Immunohistochemistry; Minocycline; Prognosis; Prurigo; Pruritus; Severity of Illness Index; Treatment Outcome

Topics: Animals; Anti-Bacterial Agents; Dermatitis, Atopic; Dermatophagoides farinae; Disease Models, Animal; Immunohistochemistry; Injections, Spinal; Male; Mice; Minocycline; Ointments; Pruritus

Erlotinib (Tarceva) is an epidermal growth factor receptor (EGFR) inhibitor, a member of a new group of molecular targeted drugs that combine high efficacy against tumours with less, often self-limiting, toxicity, compared with traditional chemotherapeutics. It is used for treatment of solid-organ tumours, especially as second- or third-line therapy for non-small-cell lung cancer. Dose-related cutaneous side-effects and diarrhoea may be a significant obstacle to treatment compliance. We present two cases with long-lasting acneiform eruptions, complicated by significant impetiginization, resulting in hospitalization in one case. The other patient suffered from sleep-disturbing, itching crusts on the scalp. As the use of EGFR inhibitors is increasing, clinicians should be aware of their side-effects. Early and timely dermatological intervention may diminish adverse events for patients treated with these agents and improve quality of life.

Topics: Aged; Anti-Bacterial Agents; Diarrhea; Dose-Response Relationship, Drug; Drug Eruptions; Emollients; Erlotinib Hydrochloride; Humans; Male; Middle Aged; Minocycline; Protein Kinase Inhibitors; Pruritus; Quinazolines

A 22-year-old Chinese woman presented with a 5-year history of an intensely pruritic eruption on her posterior neck, mid back and sacrum leaving reticulate pigmentation. The diagnosis of prurigo pigmentosa was made on the basis of the clinico-histological features and a response to minocycline. Although prurigo pigmentosa is uncommon, it has characteristic clinical and histological features. Early diagnosis and appropriate treatment result in a rapid response and prevents a progression of pigmentation.

Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Back; Diagnosis, Differential; Female; Humans; Minocycline; Neck; Prurigo; Pruritus