minocycline and Protein-Aggregation--Pathological

Aging impairs the activation of stress signaling pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here, we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficient. This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).

Topics: Animals; Caenorhabditis elegans; Longevity; Minocycline; Protein Aggregation, Pathological; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteostasis; Ribosomes