minocycline and Prostatitis

A study was conducted to assess the clinical and microbiological effects of antimicrobial treatment for chronic prostatitis as a means of defining the role of Ureaplasma urealyticum. Significant U. urealyticum cells were considered to be isolated from the prostates of 18 of 143 prostatitis patients. These patients with ureaplasma-associated prostatitis were randomly treated with either ofloxacin or minocycline for 2 weeks; 4 patients were excluded due to voluntary withdrawal. U. urealyticum was eradicated in all the patients. Symptoms were resolved in 10 patients, and leukocytes in expressed prostatic secretion were cleared in 4 patients; both drug treatments revealed similar results. Even if we exclude 3 patients with significant coexistent Staphylococcus epidermidis cells before treatment, 3 of 11 patients evaluated showed complete resolution of symptoms and clearance of leukocytes in expressed prostatic fluid. These results suggest that U. urealyticum is a causative organism in some patients with chronic prostatitis.

Topics: Adult; Aged; Chronic Disease; Humans; Leukocyte Count; Male; Middle Aged; Minocycline; Ofloxacin; Prostatitis; Ureaplasma Infections; Ureaplasma urealyticum

The relative safety and efficacy of minocycline and cephalexin were examined in patients with acute or chronic prostatitis. The multicenter study was of single-blind, parallel-group design. Forty-two men received minocycline (200-mg initial dose followed by 100 mg twice daily) and 44, cephalexin (500 mg four times daily); each antibiotic was administered orally for four weeks. A follow-up period of patient assessment extended for an additional six weeks. Evaluable data were available for 20 minocycline-treated patients and for 24 cephalexin-treated patients. Clinical cure or improvement without recurrence was seen in 65 per cent of the patients who received minocycline and in 46 per cent of those given cephalexin. Bacteriologic cure without relapse or reinfection occurred in 45 per cent of the minocycline-treated men and in 21 per cent of the cephalexin-treated men. Serious adverse clinical experiences were not encountered in either treatment group. Although several factors, mainly the small number of patients, precluded a statistical analysis of comparative efficacy, it was evident that more patients in the minocycline-treated group had both clinical and bacteriologic cures (35%) than did those in the cephalexin-treated group (21%).

Topics: Adolescent; Adult; Aged; Bacteria; Bacterial Infections; Cephalexin; Clinical Trials as Topic; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Minocycline; Prostatitis; Random Allocation; Research Design; Tetracyclines; Time Factors

In patients with chronic abacterial prostatitis, a double-blind trial of 3 months of treatment with minocycline 100 mg twice daily compared with diazepam 5 mg twice daily was undertaken. The percentage fall in polymorphonuclear leucocyte counts in the expressed prostatic secretions was much more marked after treatment with minocycline than with diazepam. Over a follow-up period of at least 12 months, further treatment was necessary in more patients originally treated with diazepam than with minocycline.

Topics: Clinical Trials as Topic; Diazepam; Double-Blind Method; Humans; Leukocyte Count; Male; Minocycline; Neutrophils; Prospective Studies; Prostatitis; Tetracyclines

Topics: Doxycycline; Humans; Male; Minocycline; Prostate; Prostatic Hyperplasia; Prostatitis; Tetracyclines

To investigate the clinical value of the prostate small extracorporeal protein (PSEP) level in the urine in evaluating the therapeutic effect on chronic prostatitis (CP).. Totally 188 CP patients were treated with minocycline and Ningmitai Capsules in our hospital and regularly returned for follow-up examination from November 2017 to November 2018. Based on the results of treatment after 4 and 8 weeks of medication, we divided the patients into a cured, an effective and an ineffective group and compared the contents of PSEP in the urine samples of the three groups of patients before and after treatment.. Compared with the baseline, the PSEP content in the urine after 4 weeks of medication was decreased in the cured group (n = 20) (［3.63 ± 3.81］ vs ［1.16 ± 0.41］ ng/ml, P < 0.05), effective group (n = 85) (［4.13 ± 4.05］ vs ［2.97 ± 2.89］ ng/ml, P > 0.05) and ineffective group (n = 83) (［4.72 ± 2.98］ vs ［3.74 ± 1.31］ ng/ml, P > 0.05), and so was that after 8 weeks of treatment in the cured group (n = 48) (［3.72 ± 3.51］ vs ［0.89 ± 0.37］ ng/ml, P < 0.05), effective group (n = 106) (［4.37 ± 3.93］ vs ［1.83 ± 0.71］ ng/ml, P < 0.05) and ineffective group (n = 34) (［4.61 ± 3.59］ vs ［3.58 ± 1.15］ ng/ml, P > 0.05).. The PSEP level in the urine can be used as an index for clinical evaluation of the therapeutic effect on chronic prostatitis.

Topics: Chronic Disease; Drugs, Chinese Herbal; Humans; Male; Minocycline; Prostatitis; Proteins; Urinalysis

The pathogenesis of chronic prostatitis/chronic pelvic pain syndrome is unknown and factors including the host's immune response and the nervous system have been attributed to the development of CP/CPPS. We previously demonstrated that mast cells and chemokines such as CCL2 and CCL3 play an important role in mediating prostatitis. Here, we examined the role of neuroinflammation and microglia in the CNS in the development of chronic pelvic pain.. Experimental autoimmune prostatitis (EAP) was induced using a subcutaneous injection of rat prostate antigen. Sacral spinal cord tissue (segments S14-S5) was isolated and utilized for immunofluorescence or QRT-PCR analysis. Tactile allodynia was measured at baseline and at various points during EAP using Von Frey fibers as a function for pelvic pain. EAP mice were treated with minocycline after 30 days of prostatitis to test the efficacy of microglial inhibition on pelvic pain.. Prostatitis induced the expansion and activation of microglia and the development of inflammation in the spinal cord as determined by increased expression levels of CCL3, IL-1β, Iba1, and ERK1/2 phosphorylation. Microglial activation in mice with prostatitis resulted in increased expression of P2X4R and elevated levels of BDNF, two molecular markers associated with chronic pain. Pharmacological inhibition of microglia alleviated pain in mice with prostatitis and resulted in decreased expression of IL-1β, P2X4R, and BDNF.. Our data show that prostatitis leads to inflammation in the spinal cord and the activation and expansion of microglia, mechanisms that may contribute to the development and maintenance of chronic pelvic pain.

Topics: Animals; Autoimmune Diseases; Chemokine CCL3; Chronic Pain; Flow Cytometry; Fluorescent Antibody Technique; Hyperalgesia; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Microglia; Minocycline; Myelitis; Pelvic Pain; Prostatitis; Real-Time Polymerase Chain Reaction; Receptors, CCR1; Receptors, CCR5; Spinal Cord

Antimicrobial resistance among Gram-negatives is increasing; treatment options are limited. Although tigecycline is used infrequently for urinary tract infection (UTI), greater use is likely as resistance increases. We report successful treatment of an episode of febrile UTI and probable prostatitis with tigecycline, and summarize the relevant literature.

Topics: Anti-Bacterial Agents; Drug Resistance, Multiple, Bacterial; Enterobacter; Enterobacteriaceae Infections; Humans; Male; Middle Aged; Minocycline; Prostatitis; Tigecycline; Treatment Outcome; Urinary Tract Infections

Topics: Anti-Bacterial Agents; Enterobacteriaceae Infections; Humans; Male; Minocycline; Prostatitis; Tigecycline; Urinary Tract Infections

To elucidate the treatment of Ureaplasma urealyticum (UU) and Chlamydia trachomatis (CT) infectious chronic prostatitis.. Forty-eight cases of chronic prostatitis patients with UU and CT infections were treated with minocycline, Chinese medicine "Qianlieshulekeli" and alpha 1A adrenoceptorblocker (tamsulosin) for 6 weeks. The change of symptoms, expressed prostatic secretion (EPS) routine, and UU and CT detection results were observed before and after the treatment. The efficacy of treatment were evaluated by CPSI score.. Remarkably effective-41 cases (85.4%), effective-5 cases (10.4%), noneffective-2 cases (4.2%). CPSI score reduced from (22 +/- 8) before treatment to (7 +/- 3) after treatment (P < 0.01). UU in 20 of 24 cases (83%) and CT in 25 of 28 cases (89%) turned negative after treatment.. The therapy combining Chinese medicine with western medicine for the treatment of UU and CT infectious chronic prostatitis is successful.

Topics: Adolescent; Adult; Chlamydia Infections; Chlamydia trachomatis; Chronic Disease; Drug Therapy, Combination; Humans; Male; Medicine, Chinese Traditional; Minocycline; Prostatitis; Ureaplasma Infections; Ureaplasma urealyticum

To report changes in the white blood cell (WBC) counts in expressed prostatic secretions (EPS) in men with pelvic symptoms undergoing thrice-weekly prostatic massage combined with antimicrobial therapy.. The study comprised a retrospective analysis of the records of 35 patients (mean age 45.3 years, range 28-70, SD, 12.03) with pelvic pain, pain in the lower back, obstructive urinary symptoms, irritative urinary symptoms, or sexual dysfunction, who had undergone the same diagnosis and treatment protocol in a genitourinary clinic in Manila, Philippines, from September 1992 to September 1995.. EPS were obtained 347 times in 35 patients (median 9 times per patient, range 6-16). In 26 of the 35 (74%) patients the WBC count in the EPS was < 10 per oil-immersion field (OIF, x1000) at the first prostatic massage. In 34 of 35 (97%) patients the WBC count rose to > or = 10 as prostatic massage continued on a thrice-weekly schedule. The mean (range, SD) initial WBC count in the EPS was 8.4 (1-48, 8.43) and the maximum was 40.9 (6-60, 19.05); the difference between these values was 32.5 (3-57, 18.78; 95% confidence interval 26.1-40.1) and the difference was statistically significant (paired t-test, P < 0.001).. The classification of patients into those with prostatodynia or prostatitis based on one EPS examination is misleading and thrice-weekly massage of the prostate is better than a single collection of EPS to obtain the most purulent sample for Gram staining and culture.

Topics: Adult; Aged; Anti-Infective Agents, Urinary; Antibiotics, Antineoplastic; Bacterial Infections; Drug Therapy, Combination; Humans; Leukocyte Count; Low Back Pain; Male; Massage; Middle Aged; Minocycline; Ofloxacin; Pain; Pelvic Pain; Prostatitis; Retrospective Studies; Sexual Dysfunction, Physiological; Urinary Retention

The authors followed 56 patients with clinical signs of urogenital phlogosis, due to Chlamydia trachomatis, treated with one of the following antimicrobial agents: miocamycin, minocycline, doxycycline. The results showed that all the antibiotics used were well tolerated and effective against Chlamydia trachomatis.

Topics: Adult; Aged; Chlamydia Infections; Chlamydia trachomatis; Doxycycline; Drug Evaluation; Female; Humans; Male; Middle Aged; Minocycline; Miocamycin; Prostatitis; Urethritis; Vaginitis

Ureaplasma urealyticum has been considered to be a pathogen of nongonococcal urethritis. To elucidate the pathogenicity of this microorganism in chronic prostatitis, U. urealyticum was isolated from patients with chronic prostatitis and prostatodynia. Using the Taylor-Robinson's method, U. urealyticum was detected in expressed prostatic secretion (EPS) or urine voided after prostatic massage (VB3) in 40 (41.2%) out of 97 patients with chronic prostatitis and 6 (20.0%) out of 30 patients with prostatodynia. Seventeen patients with U. urealyticum-positive chronic prostatitis, 13 of whom had failed to respond to the treatment by other antimicrobial agents, were treated with minocycline. In 16 (94.1%) of the 17 patients, U. urealyticum was eradicated and in 14 patients (82.4%), the elevated white blood cell count was markedly lowered in EPS or VB3. U. urealyticum may prove to be an etiological microorganism of chronic prostatitis.

Topics: Chronic Disease; Humans; Male; Minocycline; Pain; Prostatic Diseases; Prostatitis; Ureaplasma

Review of the treatment of chronic non-bacterial prostatitis, defined by the presence of more than 500 leucocytes per mm3 in the expressed prostatic secretion (EPS), showed symptomatic response after 3 months of minocycline, trimethoprim, co-trimoxazole or diazepam. Reduction in the EPS cell count was most marked with minocycline, trimethoprim was less effective and poor results were obtained with co-trimoxazole and diazepam. In the absence of established treatment for chronic non-bacterial prostatitis it is suggested that antimicrobial therapy is worth consideration.

Topics: Adult; Anti-Infective Agents, Urinary; Chronic Disease; Diazepam; Drug Combinations; Humans; Leukocyte Count; Male; Minocycline; Prostate; Prostatitis; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination

Bacterial isolates from expressed prostatic secretions were tested in vitro for susceptibility to five antimicrobial agents used in the treatment of prostatitis. Comparisons of susceptibility and resistance were made between minocycline and each of the other four agents: tetracycline, cephalexin, ampicillin, and trimethoprim-sulfamethoxazole. A high percentage of the isolates from patients with prostatitis which were resistant to tetracycline and trimethoprimsulfamethoxazole were susceptible to minocycline.

Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Cephalexin; Drug Combinations; Humans; Male; Minocycline; Penicillin Resistance; Prostate; Prostatitis; Sulfamethoxazole; Tetracycline; Trimethoprim

Trimethoprim-sulfamethoxazole, 2 tablets twice daily for 90 days, or minocycline-hydrochloride, 100 mg. twice daily for 14 days, was given to 15 and 14 men, respectively, with culture-proved bacterial prostatitis. Given as prescribed both agents seemed equally effective in controlling symptomatic recurrence during the 12 months after cessation of therapy.

Topics: Bacterial Infections; Drug Combinations; Humans; Male; Minocycline; Prostatitis; Recurrence; Sulfamethoxazole; Tetracyclines; Trimethoprim

Previous reports of melioidosis in Sabah are reviewed and a detailed account of a case, presenting as prostatitis, in a 40-year-old British male is given. The history suggested that the organism, Pseudomonas pseudomallei, was transmitted by a fly which entered the eye. Diagnosis was delayed and treatment presented some difficulty, the organism being relatively insensitive to amplicillin and gentamicin. Co-trimoxazole was the most effective, followed by minocycline. Cure was eventually achieved and after four years the patient was fit and normal, except for sterility.

Topics: Adult; Ampicillin; Drug Combinations; Gentamicins; Humans; Infertility, Male; Male; Melioidosis; Minocycline; Prostatitis; Sulfamethoxazole; Trimethoprim

Topics: Adult; Dose-Response Relationship, Drug; Doxycycline; Drug Resistance, Microbial; Humans; In Vitro Techniques; Male; Middle Aged; Minocycline; Mycoplasma; Mycoplasma Infections; Oxytetracycline; Prostatitis; Tetracyclines; Ureaplasma; Urethritis

The results of minocycline and doxycycline therapy in 41 patients with chronic prostatitis and minocycline therapy in 6 patients with acute prostatitis were evaluated. In the comparative study of chronic prostatitis, minocycline and doxycycline were given on the same dosage schedule, milligram for milligram: a loading dose of 200 mg. followed by 100 mg. twicd daily. Over-all clinical responses to therapy with either agent were generally satisfactory, and no statistically significant difference was demonstrable in this regard. In the group with chronic prostatitis treated wtih minocycline, however, all symptoms manifested before therapy had disappeared after therapy even where over-all results had been judged unsatisfactory. This was not true of the group with chronic prostatitis treated with doxycycline. Symptoms in 6 patients persisted after therapy had been terminated. Here the difference in results between the two groups was found to be statistically significant. A review of symptoms two to eight weeks after therapy revealed no significant difference between the two groups. After two years only 6 patients in the entire group with chronic prostatitis had returned with recurrent problems: 3 of these patients had been treated with minocycline and 3 had been treated with doxycycline. Results of therapy in the small series of patients with acute prostatitis treated with minocycline were generally satisfactory.

Topics: Chronic Disease; Dose-Response Relationship, Drug; Doxycycline; Escherichia; Escherichia coli; Humans; Klebsiella; Male; Minocycline; Prostatitis; Proteus mirabilis; Recurrence; Staphylococcus; Tetracyclines