minocycline and Penile-Diseases

Two cases of pyoderma gangrenosum involving the penis are presented. Treatment was difficult in both cases despite the use of high doses of prednisolone. In one case, the addition of thalidomide proved successful, whereas in the other, minocycline effected a cure.

Topics: Adult; Anti-Inflammatory Agents; Antitrichomonal Agents; Combined Modality Therapy; Drug Therapy, Combination; Erythromycin; Humans; Leprostatic Agents; Male; Metronidazole; Middle Aged; Minocycline; Penile Diseases; Penis; Prednisolone; Pyoderma Gangrenosum; Surgery, Plastic; Thalidomide

Pyoderma gangrenosum (PG) is a rare ulcerating inflammatory neutrophilic dermatosis. Different clinical manifestations have been described, including ulcerative, pustular and bullous, and vegetative variants. Classic PG usually occurs on the lower extremities (~70% of cases) but can also involve the hands, head, neck, and scrotum. Genital involvement of PG has rarely been reported. Treatment of the genital PG is usually difficult and resistance to conventional therapeutic regimens was frequently observed. The present authors reported a 16-year-old male patient who presented with progressive genital ulceration for 3 weeks. He was treated successfully low dose thalidomide (50 mg/d) and minocycline.

Topics: Adolescent; Anti-Bacterial Agents; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Male; Minocycline; Penile Diseases; Pyoderma Gangrenosum; Thalidomide; Treatment Outcome

Topics: Anti-Bacterial Agents; Doxycycline; Drug Eruptions; Genital Diseases, Male; Humans; Male; Middle Aged; Minocycline; Penile Diseases; Scrotum