minocycline and Nail-Diseases

A 65-year-old man had cutaneous hyperpigmentation that had occurred over the previous 2 1/2 years. The hyperpigmentation was extensive and involved the sclerae, nail beds, and total body; the palms and buttocks were spared. Clinical diagnosis was suggestive of hemochromatosis or heavy metal deposition. Histologic and electron microscopic findings were consistent with lysosomal iron deposition. A careful history showed that minocycline was the cause. Its use was discontinued, and after several years the patient's pigmentation is gradually returning to normal.

Topics: Aged; Drug Eruptions; Facial Dermatoses; Humans; Hyperpigmentation; Male; Microscopy, Electron; Minocycline; Nail Diseases; Pigmentation Disorders

Topics: Acne Vulgaris; Administration, Oral; Adolescent; Diagnosis, Differential; Female; Humans; Hyperpigmentation; Long-Term Care; Minocycline; Nail Diseases; Onycholysis; Photosensitivity Disorders; Sunlight

Topics: Anti-Bacterial Agents; Humans; Male; Middle Aged; Minocycline; Nail Diseases; Pigmentation Disorders; Rosacea; Skin Pigmentation

Minocycline-induced nail pigmentation is an uncommon side-effect. It usually develops after years of the therapy, and coincides with other pigmented sites. We report a 73-year-old male and a 33-year-old female developing nail discoloration after 8 weeks of therapy of 100 mg minocycline twice daily. No other pigmentation was found elsewhere on the skin, mucous membranes, teeth or sclerae of them. Our cases demonstrate that nail pigmentation can occur after short-term minocycline therapy, and propose the possibility that nail discoloration may precede other pigmentary changes.

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Male; Middle Aged; Minocycline; Nail Diseases; Pigmentation Disorders; Pseudolymphoma; Rosacea; Time Factors

Topics: Anti-Bacterial Agents; Folliculitis; Humans; Male; Middle Aged; Minocycline; Nail Diseases; Pigmentation

Topics: Anti-Bacterial Agents; Humans; Minocycline; Nail Diseases; Pigmentation Disorders

To report a case of scleral discoloration secondary to minocycline therapy.. Case report of a patient referred to a university-based cornea and external disease clinic.. The patient had been treated with oral minocycline therapy for adult facial acne for 12 years when she began to develop bilateral blue-gray discoloration of the sclera as well as of the teeth, hard palate, ears, nail beds, and skin.. Chronic systemic minocycline therapy may induce scleral pigmentary changes. The mechanism of discoloration and the long-term natural history upon cessation of minocycline are unclear.

Topics: Acne Vulgaris; Administration, Oral; Anti-Bacterial Agents; Face; Female; Humans; Middle Aged; Minocycline; Nail Diseases; Pigmentation Disorders; Scleral Diseases; Skin Pigmentation; Tooth Discoloration

Topics: Adolescent; Female; Humans; Minocycline; Nail Diseases; Pigmentation Disorders

An assessment of the occurrence rate of periungual hyperpigmentation with subungual melanoma (Hutchinson's sign) and periungual hyperpigmentation with other subungual lesions has not been published, although periungual hyperpigmentation with a pigmented streak or other pigmented lesion of the nail has been considered pathognomonic for subungual melanoma for a century. We report a case of minocycline hyperpigmentation presenting as a longitudinal pigmented streak of the nail associated with periungual hyperpigmentation. These pigmentary changes could be mistaken for Hutchinson's sign.

Topics: Adult; Diagnosis, Differential; Female; Humans; Melanoma; Minocycline; Nail Diseases; Pigmentation Disorders; Tetracyclines

Minocycline-induced cutaneous and nail bed discoloration, although uncommon, should be closely watched for during treatment. The initial changes may be subtle and may mimic other processes that may deceive both patient and physician. Patients should be counseled about the remote possibility of pigmentation with the understanding that any such changes should resolve upon discontinuation of the drug. The time required for resolution depends upon the degree of pigmentation and may take longer than a year in extensive cases.

Topics: Eye Diseases; Humans; Male; Middle Aged; Minocycline; Nail Diseases; Pigmentation Disorders; Sclera; Tetracyclines

The association of bone, tooth, nail and scleral pigmentation in a patient treated for acne with minocycline was noted. Hyperpigmentation appeared in old scar tissue, but not that present from recent surgical procedures.

Topics: Bone Diseases; Humans; Male; Middle Aged; Minocycline; Nail Diseases; Pigmentation Disorders; Skin Pigmentation; Tetracyclines; Tooth Discoloration

Minocycline, prescribed for a patient with acne, produced a photosensitivity reaction (photo-onycholysis) involving the fingernails. The onset of this reaction coincided with an increase in sun exposure and cleared several months later, when the drug was discontinued. This type of reaction has been reported to occur in patients taking tetracycline or a member of the tetracycline group of antibiotics, of which minocycline is a member. This appears to be first report of photo-onycholysis due to minocycline.

Topics: Acne Vulgaris; Adolescent; Female; Humans; Minocycline; Nail Diseases; Photosensitivity Disorders; Sunlight; Tetracyclines; Ultraviolet Rays