minocycline and Legionellosis

minocycline has been researched along with Legionellosis* in 2 studies

Other Studies

2 other study(ies) available for minocycline and Legionellosis

Article	Year
Activities of tigecycline and comparators against Legionella pneumophila and Legionella micdadei extracellularly and in human monocyte-derived macrophages. Diagnostic microbiology and infectious disease, 2011, Volume: 69, Issue:1 The activity of tigecycline against Legionellae, which are intracellular pathogens, was evaluated intracellularly in human phagocytes and extracellularly, and compared to the activities of erythromycin and levofloxacin. Clinical isolates of L. pneumophila serogroups 1, 5, and 6 and L. micdadei were tested in time-kill experiments. Extracellular experiments were done using buffered yeast extract broth. For intracellular assays, monolayers of human monocyte-derived macrophages (MDM) were infected with L. pneumophila or L. micdadei. Antibiotics (0.05-2.5 × MIC) were then added. MDM were lysed at 0, 24, 48, and 72 h and viable bacteria in the lysates were enumerated. Based on multiples of the MICs, tigecycline was less active extracellularly than levofloxacin or erythromycin. However, intracellular killing of both L. pneumophila and L. micdadei by tigecycline at 72 h was greater than for erythromycin or levofloxacin. Currently, evidence does not support the use of tigecycline as a first-line drug for treatment of Legionella infections. However, since Legionellae are intracellular pathogens, these results suggest that tigecycline should be effective for treatment of infections caused by these bacteria. Topics: Anti-Bacterial Agents; Bacterial Load; Bacterial Typing Techniques; Erythromycin; Humans; Legionella; Legionellosis; Levofloxacin; Macrophages; Microbial Sensitivity Tests; Microbial Viability; Minocycline; Ofloxacin; Serotyping; Tigecycline; Time Factors	2011
Legionella micdadei pneumonia diagnosed by culture isolation and DNA-dNA hybridization from bronchial lavage fluid. Internal medicine (Tokyo, Japan), 2004, Volume: 43, Issue:6 An 80-year-old man was admitted because of dyspnea on effort. We suspected an acute exacerbation of chronic heart failure and idiopathic interstitial pneumonia caused by right-sided pneumonia. A nodular shadow in right upper lobe spread and consolidated into the airspace, and it failed to improve despite administration of meropenem trihydrate, vancomycin hydrochloride and clindamycin. A definitive diagnosis of Legionella micdadei pneumonia was made on the basis of this organism being isolated in culture from bronchial lavage fluid and subsequent identification of Legionella micdadei using DNA-DNA hybridization. The airspace consolidation gradually improved following treatment with intravenous erythromycin and minocycline hydrochloride. Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteriological Techniques; Bronchoalveolar Lavage Fluid; DNA, Bacterial; Erythromycin; Humans; Legionella; Legionellosis; Male; Minocycline; Nucleic Acid Hybridization; Pneumonia; Treatment Outcome	2004

Article

Year

Activities of tigecycline and comparators against Legionella pneumophila and Legionella micdadei extracellularly and in human monocyte-derived macrophages.

Diagnostic microbiology and infectious disease, 2011, Volume: 69, Issue:1

The activity of tigecycline against Legionellae, which are intracellular pathogens, was evaluated intracellularly in human phagocytes and extracellularly, and compared to the activities of erythromycin and levofloxacin. Clinical isolates of L. pneumophila serogroups 1, 5, and 6 and L. micdadei were tested in time-kill experiments. Extracellular experiments were done using buffered yeast extract broth. For intracellular assays, monolayers of human monocyte-derived macrophages (MDM) were infected with L. pneumophila or L. micdadei. Antibiotics (0.05-2.5 × MIC) were then added. MDM were lysed at 0, 24, 48, and 72 h and viable bacteria in the lysates were enumerated. Based on multiples of the MICs, tigecycline was less active extracellularly than levofloxacin or erythromycin. However, intracellular killing of both L. pneumophila and L. micdadei by tigecycline at 72 h was greater than for erythromycin or levofloxacin. Currently, evidence does not support the use of tigecycline as a first-line drug for treatment of Legionella infections. However, since Legionellae are intracellular pathogens, these results suggest that tigecycline should be effective for treatment of infections caused by these bacteria.

Topics: Anti-Bacterial Agents; Bacterial Load; Bacterial Typing Techniques; Erythromycin; Humans; Legionella; Legionellosis; Levofloxacin; Macrophages; Microbial Sensitivity Tests; Microbial Viability; Minocycline; Ofloxacin; Serotyping; Tigecycline; Time Factors

2011

Legionella micdadei pneumonia diagnosed by culture isolation and DNA-dNA hybridization from bronchial lavage fluid.

Internal medicine (Tokyo, Japan), 2004, Volume: 43, Issue:6

An 80-year-old man was admitted because of dyspnea on effort. We suspected an acute exacerbation of chronic heart failure and idiopathic interstitial pneumonia caused by right-sided pneumonia. A nodular shadow in right upper lobe spread and consolidated into the airspace, and it failed to improve despite administration of meropenem trihydrate, vancomycin hydrochloride and clindamycin. A definitive diagnosis of Legionella micdadei pneumonia was made on the basis of this organism being isolated in culture from bronchial lavage fluid and subsequent identification of Legionella micdadei using DNA-DNA hybridization. The airspace consolidation gradually improved following treatment with intravenous erythromycin and minocycline hydrochloride.

Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteriological Techniques; Bronchoalveolar Lavage Fluid; DNA, Bacterial; Erythromycin; Humans; Legionella; Legionellosis; Male; Minocycline; Nucleic Acid Hybridization; Pneumonia; Treatment Outcome

2004