minocycline and Hyperplasia

An 18-year-old man with left-lobe thyroid hemiagenesis underwent isthmectomy for management of a nodule that failed to take up radioactive iodine during a nuclear scan. The resected tissue, which demonstrated nodular hyperplasia, and the remaining right lobe, were black. The association between deep staining and chronic minocycline ingestion was subsequently recognized. Twelve years later, the patient remained asymptomatic, suggesting that complete resection of tetracycline-stained thyroid tissue is unnecessary.

Topics: Acne Vulgaris; Adolescent; Hemosiderin; Humans; Hyperplasia; Male; Microscopy, Electron; Minocycline; Pigmentation Disorders; Thyroid Gland; Thyroid Nodule

Synthetic vascular conduits used in traumatic or infected fields have a high failure rate leading to catastrophic consequences including amputation and death. Although efforts to coat vascular grafts with antibiotics have had varying results, we developed a novel coating technique for expanded-polytetrafluoroethylene (ePTFE), which has proven to be effective in vitro. Thus, we hypothesized that the coated grafts would resist infection and have decreased neointimal hyperplasia when used in vivo in a large animal model.. Minocycline and rifampin suspended in a mixture of methacrylates were coated onto a 3cm segment of 6mm ePTFE (Bard, Tempe, AZ). An antibiotic-coated (ABX), adhesive-coated (AC), or control (C) ePTFE graft was then placed as an end-to-side graft into the left iliac artery of a male mongrel pig. Sterile saline or innoculum containing 3x10(8)Staphylococcus aureus (SA) or Staphylococcus epidermidis (SE) was then placed directly on the graft and the reflected peritoneum re-approximated to confine the bacteria. After 6 wk, the graft was harvested, cultured, and morphometric analyses of neointimal hyperplasia were performed.. Twenty-seven pigs had grafts placed (9 ABX, 9 AC, 9 C) and harvested. Of the nine grafts exposed to SA, the uncoated and adhesive-coated grafts averaged greater than 50,000 colonies of SA while the antibiotic-coated grafts averaged less than 50 colonies. Although not statistically significant, neointimal hyperplasia was decreased by 15% to 20% when using an ABX graft in an infected field.. The coated grafts appeared to decrease NIH formation although not significantly in this small pilot study. The methacrylate antibiotic-coated ePTFE graft did provide resistance to infection when used in infected fields.

Topics: Adhesives; Animals; Anti-Bacterial Agents; Blood Vessel Prosthesis; Coated Materials, Biocompatible; Disease Models, Animal; Hyperplasia; Male; Methacrylates; Microscopy, Electron, Scanning; Minocycline; Pilot Projects; Polytetrafluoroethylene; Prosthesis-Related Infections; Rifampin; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Swine

Persistent cutaneous infections with Mycobacterium marinum can follow exposure of injured skin to contaminated water or fish, and can be treated with second-generation tetracyclines in addition to other antimicrobials. Due to the rarity of this infection, there are few data comparing the different treatment alternatives.. We report a patient with culture-proven M. marinum who was treated with two different second-generation tetracyclines.. Our patient failed a 4-week trial of doxycycline, but responded rapidly to minocycline.. This case suggests that, despite a similar mechanism, pharmacokinetics, and even sensitivity, these two agents may differ in their effectiveness against strains of M. marinum.

Topics: Adult; Anti-Bacterial Agents; Doxycycline; Humans; Hyperplasia; Male; Minocycline; Mycobacterium Infections, Nontuberculous; Mycobacterium marinum; Skin

Topics: Adult; Humans; Hyperplasia; Lymphatic Diseases; Male; Minocycline; Skin Diseases, Infectious; Tularemia

Topics: Acne Vulgaris; Adult; Color; Female; Humans; Hyperplasia; Minocycline; Pigmentation Disorders; Tetracyclines; Thyroid Diseases; Thyroid Function Tests; Thyroid Gland