minocycline and Hidradenitis-Suppurativa

Topics: Acitretin; Administration, Cutaneous; Administration, Oral; Adolescent; Drug Therapy, Combination; Genetic Diseases, X-Linked; Hidradenitis Suppurativa; Humans; Immunoglobulins; Male; Minocycline; Nephrolithiasis; Paraproteinemias; Treatment Outcome

Topics: Acne Vulgaris; Adalimumab; Anti-Bacterial Agents; Clinical Trials as Topic; Dermatologic Agents; Drug Resistance; Evidence-Based Medicine; Hidradenitis Suppurativa; Humans; Meta-Analysis as Topic; Minocycline; Systematic Reviews as Topic

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder of the follicular epithelium.. The objective of the present study was to evaluate the effectiveness of the combination of tetracycline with colchicine in the treatment of HS.. Twenty patients (10 women and 10 men) with HS were included in an open, prospective, pilot study. All patients were treated with 100 mg minocycline administered orally once per day in combination with 0.5 mg colchicine administered twice per day for 6 months followed by a maintenance regimen of 0.5 mg colchicine administered orally twice per day for 3 months. Patients were examined at baseline and thereafter every 3 months for a total of 9 months. The efficacy of the treatment was evaluated using a physician's global assessment (PGA) scale, the Hurley scoring system, and the Dermatology Life Quality Index (DLQI).. A significant improvement in clinical manifestation was reflected in scores on the Hurley scoring system and DLQI. According to the PGA, patients achieved substantial improvement or complete remission. Clinically, all patients started to show signs of improvement within the first 3 months of therapy and continued to improve over the next 6 months.. This study indicates that the combination of the anti-inflammatory actions of colchicine and minocycline is effective in disease control in HS. Colchicine emerged as a safe option for the maintenance of the obtained result.

Topics: Adult; Anti-Bacterial Agents; Colchicine; Drug Therapy, Combination; Female; Gout Suppressants; Hidradenitis Suppurativa; Humans; Male; Middle Aged; Minocycline; Pilot Projects; Prospective Studies; Severity of Illness Index; Young Adult

Pyoderma gangrenosum (PG) and hidradenitis suppurativa (HS) are chronic inflammatory dermatoses that can be a challenge to treat. A role for TNF-alpha in their pathogenesis has been postulated in the literature. A therapeutic benefit of infliximab has been reported in recalcitrant cases of both conditions. To date, there is less evidence about the use of adalimumab for these conditions. We report a patient with severe superficial PG on a background of HS, which responded to adalumimab therapy after failure of infliximab therapy.

Topics: Adalimumab; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Comorbidity; Cyclosporine; Dapsone; Hidradenitis Suppurativa; Humans; Infliximab; Male; Methylprednisolone; Middle Aged; Minocycline; Prednisolone; Pyoderma Gangrenosum; Thalidomide; Treatment Outcome

Pyoderma gangrenosum often presents a difficult therapeutic challenge. The case is described of a 42-year-old black man with the association of cystic acne, hidradenitis suppurativa, and seronegative arthritis with pyoderma gangrenosum. The pyoderma gangrenosum ulcers remained refractory to treatment until therapies aimed in part at the associated diseases were begun. Minocycline was given for treatment of cystic acne and hidradenitis suppurativa as well as pyoderma gangrenosum. Sulfasalazine was prescribed for seronegative arthritis as well as pyoderma gangrenosum. The combination therapy permitted healing of the pyoderma gangrenosum ulcers.

Topics: Acne Vulgaris; Adult; Arthritis; Cysts; Drug Therapy, Combination; Hidradenitis Suppurativa; Humans; Male; Minocycline; Pyoderma Gangrenosum; Sulfasalazine; Treatment Outcome

Topics: Acne Vulgaris; Administration, Oral; Adolescent; Androgen Antagonists; Drug Therapy, Combination; Female; Hidradenitis Suppurativa; Humans; Minocycline; Scalp Dermatoses; Syndrome