minocycline and Foreign-Body-Migration

Although liquid injectable silicone is safe for the majority of patients treated, there are a few individuals for whom this treatment has been problematic. The problems that arise include migration and granuloma formation. In some instances the granulomas may arise years after the injections. Treatment of these granulomas typically involves the use of steroids. However, the complications associated with long-term steroid usage, as well as the limited efficacy in some patients, have prompted clinicians to seek alternative treatments. This article presents the case of a woman who had delayed granuloma formation to liquid injectable silicone treated with a combination of minocycline and celocoxib. The histology of this case, as well as potential mechanisms of action for the treatment, are also presented.

Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Drug Therapy, Combination; Female; Foreign-Body Migration; Granuloma, Foreign-Body; Humans; Injections; Middle Aged; Minocycline; Pyrazoles; Silicones; Sulfonamides; Time Factors

Siliconoma represents a granulomatous foreign body reaction to silicone, which is often used for soft tissue augmentation. Although considered as biologically inert for a long time, silicone has been implicated in various undesirable local and systemic reactions, sometimes with a latency period of up to several decades. Treatment of siliconomas is difficult and granulomas involving the face are a therapeutic challenge. We present a 43-year-old woman with a severely disfiguring facial silicone granuloma who was successfully treated with minocycline.

Topics: Adult; Anti-Inflammatory Agents; Cosmetic Techniques; Facial Dermatoses; Female; Foreign-Body Migration; Granuloma, Foreign-Body; Humans; Injections; Minocycline; Silicones