minocycline and Fish-Diseases

Zebrafish (Danio rerio) are a popular model organism used in a growing number of research fields. Maintaining healthy, disease-free laboratory fish is important for the integrity of many of these studies. Mycobacteriosis is a chronic bacterial infection caused by several Mycobacterium spp. and is the second most common disease found in laboratory zebrafish. Current mycobacteriosis control measures recommend the removal of infected fish and in severe outbreaks, depopulation. These measures can be effective, but less disruptive measures should be assessed for controlling mycobacteriosis, particularly when valuable and rare lines of fish are affected. Here, the in vivo efficacy of two drug candidates, tigecycline (1 μg g

Topics: Animals; Anti-Bacterial Agents; Clarithromycin; Female; Fish Diseases; Male; Minocycline; Mycobacterium chelonae; Mycobacterium Infections; Tigecycline; Time Factors; Zebrafish