minocycline and Facial-Dermatoses

A 65-year-old man had cutaneous hyperpigmentation that had occurred over the previous 2 1/2 years. The hyperpigmentation was extensive and involved the sclerae, nail beds, and total body; the palms and buttocks were spared. Clinical diagnosis was suggestive of hemochromatosis or heavy metal deposition. Histologic and electron microscopic findings were consistent with lysosomal iron deposition. A careful history showed that minocycline was the cause. Its use was discontinued, and after several years the patient's pigmentation is gradually returning to normal.

Topics: Aged; Drug Eruptions; Facial Dermatoses; Humans; Hyperpigmentation; Male; Microscopy, Electron; Minocycline; Nail Diseases; Pigmentation Disorders

Postacne osteoma cutis is a rare complication of acne vulgaris. If it occurs during a course of tetracycline or minocycline therapy, pigmented osteomas can occur as a result of tetracycline or minocycline bone complexes. We report a case of pigmented postacne osteoma cutis that developed after extensive acne surgery and a 2- to 3-month course of minocycline. Previously reported cases have been treated surgically, but our patient responded to 0.05% tretinoin cream, with transepidermal elimination of some osteomas.

Topics: Acne Vulgaris; Adult; Facial Dermatoses; Facial Neoplasms; Female; Humans; Minocycline; Osteoma; Pigmentation Disorders; Skin Neoplasms

FMX101 4% topical minocycline foam has been shown to be an effective and safe treatment for acne vulgaris (AV).. To further evaluate the efficacy and safety of FMX101 4% in treating moderate to severe acne vulgaris.. A 12-week, multicenter, randomized (1:1), double-blind, vehicle-controlled study was conducted. Coprimary end points were the absolute change in inflammatory lesion count from baseline and the rate of treatment success (Investigator's Global Assessment score of 0 or 1 with a ≥2-grade improvement).. There were 1488 participants in the intent-to-treat population. The FMX101 4% group had significantly greater reductions in the number of inflammatory lesions from baseline (P < .0001) and a greater rate of treatment success based on Investigator's Global Assessment (P < .0001) versus the foam vehicle group at week 12. FMX101 4% was generally safe and well tolerated.. The efficacy and safety of FMX101 4% were not characterized in participants with mild AV.. FMX101 4% topical minocycline foam was effective and safe for the treatment of moderate to severe AV.

Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Child; Double-Blind Method; Facial Dermatoses; Female; Humans; Male; Minocycline; Treatment Outcome; Young Adult

Acne vulgaris is a prevalent skin disorder impairing both physical and psychosocial health. This study was designed to investigate the effectiveness of photodynamic therapy (PDT) combined with minocycline in moderate to severe facial acne and influence on quality of life (QOL).. Ninety-five patients with moderate to severe facial acne (Investigator Global Assessment [IGA] score 3-4) were randomly treated with PDT and minocycline (n = 48) or minocycline alone (n = 47). All patients took minocycline hydrochloride 100 mg/d for 4 weeks, whereas patients in the minocycline plus PDT group also received 4 times PDT treatment 1 week apart. IGA score, lesion counts, Dermatology Life Quality Index (DLQI), and safety evaluation were performed before treatment and at 2, 4, 6, and 8 weeks after enrolment.. There were no statistically significant differences in characteristics between 2 treatment groups at baseline. Minocycline plus PDT treatment led to a greater mean percentage reduction from baseline in lesion counts versus minocycline alone at 8 weeks for both inflammatory (-74.4% vs -53.3%; P < .001) and noninflammatory lesions (-61.7% vs -42.4%; P < .001). More patients treated with minocycline plus PDT achieved IGA score <2 at study end (week 8: 30/48 vs 20/47; P < .05). Patients treated with minocycline plus PDT got significant lower DLQI at 8 weeks (4.4 vs 6.3; P < .001). Adverse events were mild and manageable.. Compared with minocycline alone, the combination of PDT with minocycline significantly improved clinical efficacy and QOL in moderate to severe facial acne patients.

Topics: Acne Vulgaris; Adolescent; Adult; Chi-Square Distribution; Combined Modality Therapy; Facial Dermatoses; Female; Follow-Up Studies; Humans; Male; Minocycline; Photochemotherapy; Prospective Studies; Quality of Life; Severity of Illness Index; Treatment Outcome; Young Adult

There is a lack of evidence for minocycline in the treatment of rosacea.. To compare the efficacy and safety of doxycycline 40 mg vs. minocycline 100 mg in papulopustular rosacea.. In this randomized, single-centre, 1 : 1 allocation, assessor-blinded, noninferiority trial, patients with mild-to-severe papulopustular rosacea were randomly allocated to either oral doxycycline 40 mg or minocycline 100 mg for a 16-week period with 12 weeks of follow-up. Our primary outcomes were the change in lesion count and change in patient's health-related quality of life (using RosaQoL). Intention-to-treat and per protocol analyses were performed.. Of the 80 patients randomized (40 minocycline, 40 doxycycline), 71 were treated for 16 weeks. Sixty-eight patients completed the study. At week 16, the median change in lesion count was comparable in both groups: doxycycline vs. minocycline, respectively 13 vs. 14 fewer lesions. The RosaQoL scores were decreased for both doxycycline and minocycline, respectively by 0·62 and 0·86. Secondary outcomes were comparable except for Investigator's Global Assessment success, which was seen significantly more often in the minocycline group than in the doxycycline group (60% vs. 18%, P < 0·001). At week 28, outcomes were comparable, except for RosaQoL scores and PaGA, which were significantly different in favour of minocycline (P = 0·005 and P = 0·043, respectively), and fewer relapses were recorded in the minocycline group than in the doxycycline group (7% and 48%, respectively; P < 0·001). No serious adverse reactions were reported.. Minocycline 100 mg is noninferior to doxycycline 40 mg in efficacy over a 16- week treatment period. At follow-up, RosaQoL and PaGA were statistically significantly more improved in the minocycline group than in the doxycycline group, and minocycline 100 mg gives longer remission. In this study there was no significant difference in safety between these treatments; however, based on previous literature minocycline has a lower risk-to-benefit ratio than doxycycline. Minocycline 100 mg may be a good alternative treatment for those patients who, for any reason, are unable or unwilling to take doxycycline 40 mg.

Topics: Administration, Oral; Anti-Bacterial Agents; Dermatologic Agents; Doxycycline; Drug Administration Schedule; Facial Dermatoses; Female; Humans; Male; Minocycline; Quality of Life; Recurrence; Rosacea; Single-Blind Method; Treatment Outcome

Topics: Acne Vulgaris; Administration, Cutaneous; Adolescent; Adult; Anti-Bacterial Agents; Double-Blind Method; Facial Dermatoses; Female; Humans; Male; Minocycline; Prospective Studies; Severity of Illness Index; Young Adult

Topics: Facial Dermatoses; Humans; Hyperpigmentation; Lupus Vulgaris; Minocycline; Rosacea

Topics: Administration, Cutaneous; Administration, Oral; Adult; Biopsy; Dermatitis, Contact; Dermatitis, Occupational; Drug Therapy, Combination; Facial Dermatoses; Glass; Humans; Male; Metronidazole; Minocycline; Ointments; Skin; Tacrolimus; Treatment Outcome

Topics: Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents; Drug Therapy, Combination; Facial Dermatoses; Female; Humans; Male; Middle Aged; Minocycline; Prednisone; Sarcoidosis

Topics: Adult; Aged; Anti-Inflammatory Agents; Facial Dermatoses; Female; Humans; Hydroa Vacciniforme; Lymphoma, T-Cell, Cutaneous; Minocycline; Skin Neoplasms; Sunscreening Agents; Tacrolimus

Topics: Aged; Biomarkers; Biopsy; Drug Administration Schedule; Erythema; Facial Dermatoses; Humans; Immunohistochemistry; Lymphedema; Male; Mast Cells; Minocycline; Time Factors; Treatment Outcome

Topics: Anti-Bacterial Agents; Facial Dermatoses; Granuloma, Giant Cell; Humans; Male; Middle Aged; Minocycline

Topics: Anti-Bacterial Agents; Diagnosis, Differential; Drug Eruptions; Facial Dermatoses; Female; Humans; Hyperpigmentation; Middle Aged; Minocycline

Demodex mites seem to serve as a pathogenic trigger in many Demodex-associated diseases such as rosacea. In facial skin of patients with rosacea significantly higher numbers of Demodex mites have been shown compared with healthy controls. Reflectance confocal microscopy (RCM) allows the detection and quantification of Demodex mites in vivo noninvasively. It is hypothesized that a reduction of Demodex mites under rosacea therapy can be monitored by RCM.. To use RCM to monitor the density of Demodex mites in patients with rosacea before and after treatment.. In 25 patients with facial rosacea RCM was performed before and after therapy. Mosaics of 5 × 5 mm(2) and 8 × 8 mm(2) were scanned, and the total numbers of mites per follicle and per area were counted, along with the number of follicles per area.. In all patients Demodex folliculorum could be detected and quantified using RCM. RCM showed significant differences pre- and post-treatment (P = 0.0053 for 5 × 5 mm(2) and P < 0.001 for 8 × 8 mm(2)). The mean numbers of mites per follicle were 0.63 (range 0.16-2.28) per 8 × 8 mm(2) area and 0.70 (range 0.11-2.20) per 5 × 5 mm(2) area before treatment, and 0.41 (range 0.074-1.75) and 0.51 (range 0.094-1.70), respectively, after treatment. The corresponding mean numbers of mites were 155 (range 45-446) and 86.2 (range 12-286), respectively, before treatment and 96.2 (range 18-363) and 58.5 (range 12-230), respectively, after treatment.. By RCM, a reduction in the density of Demodex mites in facial skin of patients with rosacea under therapy, correlating to clinical improvement, can be quantified and monitored noninvasively. Possible reasons for this therapeutic effect are discussed.

Topics: Adult; Aged; Animals; Anti-Infective Agents; Doxycycline; Drug Therapy, Combination; Facial Dermatoses; Female; Hair Follicle; Humans; Male; Metronidazole; Microscopy, Confocal; Middle Aged; Minocycline; Mite Infestations; Mites; Prospective Studies; Rosacea; Treatment Outcome

Topics: Animals; Facial Dermatoses; Female; Humans; Male; Minocycline; Mite Infestations; Rosacea

Microneedle therapy includes skin puncture with multiple micro-sized needles to promote skin rejuvenation or increase transdermal delivery of topical medications. In cosmetic practices, various cosmeceuticals are applied before microneedling to enhance the therapeutic effects. This results in intradermal tattooing of the topical product. Despite rapid increase in the use of microneedles in dermatology, there are few data about their safety.. We describe 3 women, aged 40s to 60s, who developed open [corrected] facial granulomas following microneedle therapy for skin rejuvenation. Two patients had undergone microinjection of the same branded topical moisturizer (Vita C Serum; Sanítas Skincare) during microneedle therapy. Biopsy in all cases showed foreign body-type granulomas. Results of tissue cultures were negative. Chest radiography and serum angiotensin-converting enzyme findings were normal. The first 2 patients had a positive patch test reaction to Vita C Serum. Initial treatment with topical and oral corticosteroids was ineffective. Therapy with doxycycline hydrochloride and minocycline hydrochloride led to partial improvement in one case and resolution in another.. Application of topical products prior to microneedling can introduce immunogenic particles into the dermis and potentiate local or systemic hypersensitivity reactions. Because the microneedle therapy system is accessible for home use, health care providers need to be aware of its potential consequences.

Topics: Adult; Dermatologic Agents; Doxycycline; Drug Eruptions; Facial Dermatoses; Female; Follow-Up Studies; Granuloma, Foreign-Body; Humans; Microinjections; Middle Aged; Minocycline; Needles; Rejuvenation; Skin Aging

Patients with rosacea frequently report increased skin sensitivity, with features suggestive of an abnormal stratum corneum (SC) permeability barrier. Sebum, pH and hydration levels influence epidermal homeostasis. The correlation of changes in these parameters with clinically effective treatment has not been previously analysed.. To analyse sebum, pH and epidermal hydration levels of patients with papulopustular rosacea (PPR) before and after treatment with systemic minocycline.. We analysed sebum casual levels, pH and hydration along with erythema levels (as a marker of disease activity and response to treatment) on seven designated facial sites of 35 patients with active PPR and compared the results with values on the same sites of 34 control subjects with normal facial skin. To determine the effect of minocycline on these parameters, we re-examined the patients with PPR at the same sites after a 6-week course of treatment.. Patients with untreated PPR had significantly increased erythema indices, normal sebum casual levels, a more alkaline centrofacial region and reduced epidermal hydration levels compared with controls. Treatment with minocycline resulted in reduced erythema and increased hydration levels, with the most marked changes evident in the cheeks (13·3% reduction in erythema indices, P < 0·001; 12·4% increase in hydration levels, P = 0·012). There was no change in skin pH or sebum casual levels following treatment.. Patients with PPR have increased erythema indices, normal sebum casual levels, a more alkaline centrofacial region and reduced epidermal hydration levels compared with control subjects. Treatment with systemic minocycline reduces erythema and increases hydration, in the absence of any change in skin pH or sebum casual levels.

Topics: Adult; Aged; Body Water; Case-Control Studies; Dermatologic Agents; Electric Capacitance; Erythema; Facial Dermatoses; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Minocycline; Rosacea; Sebum; Treatment Outcome

A 52-year-old man presented with a progressive grey-black pigmentation of facial skin, sclera and teeth. The cause was long-term ingestion of minocycline, as confirmed by history and skin biopsy. Minocycline-induced hyperpigmentation can be divided into four main patterns based on clinical appearance, distribution, light- and electron microscopic characteristics. Some patterns can manifest within weeks of initiating therapy. One must be alert to the early signs and warn the patient about the often cosmetically disturbing and persistent minocycline-induced hyperpigmentation.

Topics: Anti-Bacterial Agents; Diagnosis, Differential; Drug Eruptions; Facial Dermatoses; Humans; Hyperpigmentation; Male; Middle Aged; Minocycline; Scleral Diseases; Tooth Discoloration

A case of rapidly relapsing pyoderma gangrenosum (PG) of the left preauricular area with no undermined borders is described. This might be considered a case of malignant pyoderma (PM), a rare variety of PG. Five months after complete healing obtained with systemic corticosteroids, the preauricular lesion of PG relapsed. As retreatment with oral methylprednisolone induced glucose intolerance and high arterial pressure, sulfa drugs were initially employed with a transitory recovery of the skin lesion. A successive prolonged course with minocycline induced a new complete resolution. To date, at six months' follow-up, the patient is relapse-free. This case confirms that sulfa drugs and minocycline may also be considered alternative therapies in PM. PM is a variety of PG characterized by specific morphological features, a higher tendency to relapse, and poor responsiveness to treatment.

Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Anti-Infective Agents; Facial Dermatoses; Humans; Male; Middle Aged; Minocycline; Pyoderma Gangrenosum; Secondary Prevention; Trimethoprim, Sulfamethoxazole Drug Combination

We present the case of a 16-year-old girl with a 2-year history of progressive development of milia en plaque of the eyelids.

Topics: Adolescent; Anti-Bacterial Agents; Caustics; Drug Therapy, Combination; Eyelid Diseases; Facial Dermatoses; Female; Humans; Minocycline; Trichloroacetic Acid

Topics: Aged; Anti-Bacterial Agents; Diagnosis, Differential; Drug Eruptions; Facial Dermatoses; Humans; Hyperpigmentation; Male; Minocycline; Neck

Topics: Aged; Esthetics; Facial Dermatoses; Female; Humans; Hyperpigmentation; Laser Therapy; Minocycline; Patient Satisfaction; Risk Assessment; Rosacea; Severity of Illness Index; Treatment Outcome

Rothmann-Makai syndrome (lipogranulomatosis subcutanea) is a rare variant of Weber-Christian disease, but lacks visceral involvements and systemic manifestations. We herein report the case of a 56-year-old Chinese woman with this disorder who complained of subcutaneous tender nodules over her extremities, trunk, and face of 2 years' duration. She was firstly treated with 300 mg of oral roxythromycin for 8 weeks and subsequently treated with 400 mg of oral clarithromycin for the next 8 weeks. However, no significant effect was observed. She was then administered 200 mg of oral minocycline hydrochloride. After 1 week, her skin symptoms rapidly improved and no relapse has been observed in a follow-up period of 3 months. Considering that tetracycline antibiotics, but not macrolide antibiotics, inhibit the activity of pancreatic lipase in vitro, the efficiency of tetracycline antibiotics may be a clue to clarifying the pathogenesis of this disorder.

Topics: Anti-Bacterial Agents; Arm; Clarithromycin; Facial Dermatoses; Fat Necrosis; Female; Humans; Leg Dermatoses; Middle Aged; Minocycline; Panniculitis, Nodular Nonsuppurative; Roxithromycin; Tetracyclines; Thorax

Pyoderma faciale is an uncommon acute presentation of rosacea. Edema, nodules, and draining sinuses may occur. Women in their early 20s are typically affected, and severe scarring may result in untreated cases. We report the case of a woman in whom a biopsy helped establish an early diagnosis so that decisive intervention could be initiated and scarring avoided. The histologic features of pyoderma faciale only rarely have been described and are illustrated in this case.

Topics: Adult; Anti-Bacterial Agents; Biopsy; Diagnosis, Differential; Drug Therapy, Combination; Facial Dermatoses; Female; Humans; Minocycline; Prednisone; Pyoderma

Siliconoma represents a granulomatous foreign body reaction to silicone, which is often used for soft tissue augmentation. Although considered as biologically inert for a long time, silicone has been implicated in various undesirable local and systemic reactions, sometimes with a latency period of up to several decades. Treatment of siliconomas is difficult and granulomas involving the face are a therapeutic challenge. We present a 43-year-old woman with a severely disfiguring facial silicone granuloma who was successfully treated with minocycline.

Topics: Adult; Anti-Inflammatory Agents; Cosmetic Techniques; Facial Dermatoses; Female; Foreign-Body Migration; Granuloma, Foreign-Body; Humans; Injections; Minocycline; Silicones

Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents; Diagnosis, Differential; Edema; Erythema; Facial Dermatoses; Humans; Male; Metronidazole; Middle Aged; Minocycline; Syndrome; Time Factors; Treatment Outcome

Granulomatous rosacea is a variant of rosacea that may present similar to other granulomatous diseases. We present the case of a 45-year-old woman with a 2-year history of facial erythema with multiple papules and pustules on the cheeks, chin, and glabella. The patient responded to minocycline, resulting in healing 6 months without residual scarring. This patient's clinical and histological presentation and treatment outcome are to our assessment consistent with granulomatous rosacea. However, other clinically and histologically related entities will be discussed. These entities include, but are not limited to, perioral dermatitis, granulomatous periorificial dermatitis, lupus miliaris disseminatus faciei, facial afro-caribbean eruption syndrome, and sarcoidosis.

Topics: Dermatitis, Perioral; Diagnosis, Differential; Facial Dermatoses; Female; Granuloma; Humans; Middle Aged; Minocycline; Remission Induction; Rosacea; Skin Diseases, Papulosquamous; Tuberculoma

Alkaptonuria, a rare autosomal-recessive disorder caused by mutations in the HGD gene and a deficiency of homogentisate 1,2-dioxygenase, is characterized by accumulation of homogentisic acid (HGA), ochronosis, and destruction of connective tissue resulting in joint disease. Certain medications have been reported to cause cutaneous hyperpigmentation resembling that of alkaptonuria. We present 5 such cases. Eighty-eight patients with a possible diagnosis of alkaptonuria were examined at the National Institutes of Health Clinical Center between June 2000 and March 2004. The diagnosis of alkaptonuria was confirmed or ruled out by measurement of HGA in the urine. Five patients with findings consistent with ochronosis, including pigmentary changes of the ear and mild degenerative disease of the spine and large joints, were diagnosed clinically as having alkaptonuria, but the diagnosis was withdrawn based on normal urine HGA levels. All 5 patients were women who had taken minocycline for dermatologic or rheumatologic disorders for extended periods. Minocycline-induced hyperpigmentation should be considered in the differential diagnosis of ochronosis. This could be of increased significance now that minocycline and other tetracyclines have been proposed as therapeutic options for rheumatoid arthritis, bringing a new population of patients with ochronosis and arthritis to medical attention with the potential, but incorrect, diagnosis of alkaptonuria.

Topics: Abscess; Acne Vulgaris; Adult; Aged; Alkaptonuria; Arthralgia; Arthritis, Rheumatoid; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Hyperpigmentation; Middle Aged; Minocycline; Radiography

Lupoid sycosis is a rare cicatricial form of chronic folliculitis commonly seen in men after puberty. It usually involves the beard area and is refractory to treatment. We here report two cases of lupoid sycosis; one had additional involvement of the pubic area. Both patients showed complete clearance with minocycline.

Topics: Adult; Biopsy, Needle; Chronic Disease; Facial Dermatoses; Folliculitis; Follow-Up Studies; Humans; Immunohistochemistry; Male; Minocycline; Pubic Bone; Severity of Illness Index; Treatment Outcome

Ofuji's disease, also referred to as classic eosinophilic pustular folliculitis, is a rare dermatosis of unknown origin for which there is no uniformly effective treatment.. Twenty patients with Ofuji's disease (classic eosinophilic pustular folliculitis) evaluated in our department from January 1978 to June 1999 were studied clinically and histopathologically. Laboratory data, treatments, and clinical courses were evaluated in 12 of these individuals.. Nissl modified staining revealed moderate increases of mast cells around hair follicles and sebaceous glands in all 20 patients; the majority of the infiltrating mast cells were tryptase-positive and chymase-negative. Eight of 11 patients treated with oral indomethacin responded completely.. Indomethacin is an effective therapy for Ofuji's disease. Tryptase-positive and chymase-negative mast cells might play some role in the pathogenesis of Ofuji's disease.

Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arm; Back; Dapsone; Facial Dermatoses; Female; Folliculitis; Foot; Humans; Immunohistochemistry; Indomethacin; Japan; Male; Mast Cells; Middle Aged; Minocycline; Prednisolone; Sulfamethoxazole; Thorax; Treatment Outcome

Topics: Adult; Anti-Bacterial Agents; Facial Dermatoses; Humans; Male; Minocycline; Mucinosis, Follicular; Treatment Outcome

A 35-year-old Kuwaiti field worker presented with a history of an asymptomatic, erythematous plaque on the right side of the nasal bridge. It soon extended to the malar area, being studded with multiple yellowish papules (Fig. 1). He denied any history of photosensitivity, drug intake, local trauma, topical applications, or ionizing radiations to that area. Examination revealed an erythematous, 1.5 x 3 cm plaque on the right nasal fold, extending to the malar area, overlain by a group of tiny yellowish papules (15-20 in number). He also had a few discrete milia on the right cheek. The histology (Fig. 2) revealed multiple keratin-filled cysts, surrounded by a dense lymphocytic infiltrate, findings consistent with milia; 0.05% tretinoin was prescribed twice daily for 1 month without improvement; minocycline, 100 mg daily, was then employed, and at 1 month of follow-up there was a significant decrease in erythema and milia count.

Topics: Adult; Anti-Bacterial Agents; Diagnosis, Differential; Facial Dermatoses; Humans; Male; Miliaria; Minocycline

Topics: Aged; Anti-Bacterial Agents; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Minocycline; Pigmentation Disorders; Rosacea; Scleral Diseases

Topics: Adult; Anti-Bacterial Agents; Eyelid Diseases; Facial Dermatoses; Female; Humans; Male; Middle Aged; Minocycline; Skin Diseases, Papulosquamous

The incidence of cutaneous bacterial infection after carbon dioxide (CO2 laser resurfacing is increasing. Patients with staphylococcal colonization of their anterior nares may be at greater risk for postoperative cutaneous colonization and/or infection, which can potentially cause scarring.. We present a case report of methicillin-resistant Staphylococcus aureus secondary infection of the skin after CO2 laser resurfacing. We discuss the possible etiologies of this patient's infection, her postoperative management, and preoperative suggestions for possibly preventing infection.. A 49-year-old woman was treated with CO2 laser resurfacing for moderate actinic damage and facial rhytides. She developed a cutaneous infection with methicillin-resistant S. aureus, which caused diffuse linear scarring on her cheeks and upper lip.. The patient was successfully treated with oral minocycline, rifampin, and topical mupiricin ointment to her cutaneous erosions.. We propose that it would be helpful for patients undergoing CO2 laser resurfacing to have their nares cultured to see if they are staphylococcal carriers. If a patient is found to be a carrier, mupiricin ointment can be used preoperatively treat to the nares, to help decrease the risk of infection of the skin from this potential source.

Topics: Dermatologic Surgical Procedures; Drug Therapy, Combination; Facial Dermatoses; Female; Humans; Laser Therapy; Methicillin Resistance; Middle Aged; Minocycline; Mupirocin; Rifampin; Skin Aging; Skin Diseases, Bacterial; Staphylococcal Infections; Staphylococcus aureus; Surgery, Plastic; Surgical Wound Infection

Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Facial Dermatoses; Folliculitis; Follow-Up Studies; Humans; Male; Minocycline

Cutaneous hyperpigmentations are well-documented, but nevertheless rare side-effects of high-dose or long-term minocycline therapy. The pigmental changes, may last for years, even though therapy has been abrogated. To date, no safe and effective therapy has been described to target this cosmetically disturbing sequela.. A 57-year-old female patient with extensive pigmental changes of the face due to long-term minocycline therapy was treated in eight consecutive sessions with the Q-switched Nd:YAG-laser (1,064-nm wavelength, 5- to 7-nsec impulse length).. A 90% resolution of the pigmentation could be achieved after five treatments. After the last session the lesions were completely gone; no hypopigmentation scars, or other side-effects were observed.. Treatment with the Q-switched Nd:YAG laser seems to be an effective, safe, and easily applicable strategy for the therapy of minocycline-induced hyperpigmentations.

Topics: Aluminum Silicates; Anti-Bacterial Agents; Facial Dermatoses; Female; Humans; Hyperpigmentation; Laser Therapy; Middle Aged; Minocycline; Neodymium; Remission Induction; Safety; Yttrium

Fifty-four patients taking minocycline for acne or rosacea were assessed for adverse effects. Their mean duration of treatment was 17 months, and their average cumulative dose was 47 g. No symptoms attributable to the therapy were reported. Biochemistry and haematology profiles were normal. There was no evidence of an adverse effect on thyroid function. Skin pigmentation was detected in eight patients (14.8%). Five patients had diffuse facial pigmentation, and three patients had localized pigmentation at the site of a scar or injury. Diffuse pigmentation occurred only in patients who had been on treatment for 3 years or more; 50% of such patients were affected. Age and solar damage may also have been factors in this type of pigmentation. Localized pigmentation occurred at sites of previous tissue damage, and was not directly related to the duration of therapy. Patients who receive long-term minocycline therapy should be regularly monitored for the development of pigmentation.

Topics: Acne Vulgaris; Adolescent; Adult; Age Factors; Aged; Cicatrix; Facial Dermatoses; Female; Humans; Male; Middle Aged; Minocycline; Pigmentation Disorders; Rosacea; Skin Aging; Skin Pigmentation; Thyroid Gland; Thyrotropin; Thyroxine; Time Factors

A 26-year-old female developed a severe acneiform eruption on her face, chest and back soon after she started taking lithium carbonate for psychosis. Histopathological examination revealed it to be folliculitis, rather than true acne. The eruption continued for six months but was resolved three months after discontinuing the drug. It has not reappeared in the following 3 years.

Topics: Acne Keloid; Adult; Drug Eruptions; Facial Dermatoses; Female; Humans; Japan; Lithium Carbonate; Minocycline; Psychotic Disorders

Topics: Administration, Cutaneous; Diagnosis, Differential; Facial Dermatoses; Humans; Male; Middle Aged; Minocycline; Rosacea; Steroids

Topics: Adult; Facial Dermatoses; Female; Granuloma; Humans; Minocycline; Rosacea

Two cases of cutaneous nocardial infection are reported. The Nocardia species are gram-positive, partially acid-fast bacteria. Cutaneous involvement may develop as one of four types: (1) mycetoma, (2) lymphocutaneous (sporotrichoid) infection, (3) superficial skin infection, or (4) systemic disease with cutaneous involvement. A review of each of these types of infection is included, as well as potential clues that may suggest the diagnosis of nocardiosis.

Topics: Abscess; Aged; Amikacin; Drug Combinations; Facial Dermatoses; Humans; Lymphangitis; Male; Minocycline; Mycetoma; Nocardia; Nocardia asteroides; Nocardia Infections; Skin Diseases, Infectious; Skin Ulcer; Sulfamethoxazole; Sulfonamides; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination