minocycline and Epstein-Barr-Virus-Infections

An 81-year-old female experiencing high fever, fatigue, and loss of appetite was admitted to our hospital and diagnosed with acute cholecystitis. Her condition did not improve and an eschar and erythema subsequently appeared. We then diagnosed Japanese spotted fever (JSF). She recovered immediately after the administration of minocycline. This case differed from other cases because the patient had a remarkably acute hepatic failure.. Considering that the present case might be associated with other factors, we performed a repeat polymerase chain reaction (PCR) test on the patient's blood that had been collected on admission and stored.. Epstein-Barr virus (EBV) was detected in her blood by PCR.. We consider this case might be associated with EBV.

Topics: Aged, 80 and over; Anti-Bacterial Agents; Cefoperazone; Cholecystitis, Acute; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Liver Failure, Acute; Minocycline; Polymerase Chain Reaction; Rickettsia; Rickettsia Infections; Sulbactam