minocycline and Cystitis

Topics: Acute Disease; Adolescent; Adult; Chronic Disease; Clinical Trials as Topic; Cystitis; Female; Humans; Male; Middle Aged; Minocycline; Pyelitis; Sulfamethoxazole; Tetracyclines; Trimethoprim; Urinary Tract Infections

We examined the effect of repeated cold (RC) stress on cyclophosphamide (CPA)-induced cystitis/bladder pain in mice, in relation to macrophage activity. CPA, given i.p. at 400 mg/kg, caused bladder pain symptoms accompanying cystitis in both unstressed and RC-stressed mice, which were prevented by the macrophage inhibitor minocycline. A low dose, that is, 200 mg/kg, of CPA still produced bladder pain symptoms in unstressed but not RC-stressed mice. Lipopolysaccharide-induced cytokine production in peritoneal macrophages from RC-stressed mice was less than that from unstressed mice. Thus, RC stress appears to reduce CPA-induced bladder pain in mice, which may be associated with the decreased macrophage activity.

Topics: Animals; Cold Temperature; Cyclophosphamide; Cystitis; Cytokines; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Minocycline; Pain; Stress, Physiological; Urinary Bladder

A 60-year-old woman presented with a 13-day history of a generalized erythematous rash accompanied by fever, periorbital edema and axillary lymphadenopathy. Prior to the appearance of the rash, the patient had been treated with intermittent courses of oral minocycline for cystitis. The patient was diagnosed with drug-induced hypersensitivity syndrome (DIHS) due to minocycline. During the admission, infectious endocarditis was suspected and the patient was treated with i.v. gammaglobulin (0.4 g/kg per day). The following day, the patient suffered from systemic deterioration and symptomatic low blood pressure that prompted repeat echocardiography which revealed an ejection fraction of 10%. DIHS-associated myocarditis was suspected and management with circulation assistance devices and steroid pulse therapy were started, resulting in satisfactory resolution. A rise in titer of human herpesvirus-6, cytomegalovirus and Herpes simplex virus-1 antibodies was detected. Although minocycline-induced myocarditis is rare, this severe drug reaction should be considered with DIHS.

Topics: Anti-Bacterial Agents; Cystitis; Drug Hypersensitivity Syndrome; Female; Humans; Middle Aged; Minocycline; Myocarditis

In the course of treating twenty patients with acute urinary tract infections, the toxicity and efficacy of a small dosage regimen (50 mg p.o., t.i.d.) of minocycline were evaluated. No vestibular symptoms attributable to minocycline treatment were observed in any of the cases entered in this study. Adverse reactions included mild nausea in 1 case and urticaria in another case. Minocycline with this dosage regimen sterilized the urine of 90% of patients with acute urinary tract infections.

Topics: Adult; Aged; Bacterial Infections; Bacteriuria; Cystitis; Drug Resistance, Microbial; Female; Humans; Male; Middle Aged; Minocycline; Pyuria; Tetracyclines; Urinary Tract Infections

Topics: Adult; Aged; Cystitis; Drug Resistance, Microbial; Escherichia coli; Female; Humans; Infusions, Parenteral; Klebsiella; Male; Middle Aged; Minocycline; Postoperative Complications; Prostatic Hyperplasia; Prostatic Neoplasms; Proteus; Pseudomonas; Pyelonephritis; Staphylococcus; Tetracycline; Urologic Diseases

Topics: Adult; Aged; Bronchitis; Bronchopneumonia; Cholangitis; Cholecystitis; Cystitis; Female; Humans; Male; Middle Aged; Minocycline; Pyelonephritis; Tetracycline