minocycline and Conjunctival-Diseases

Topics: Aged, 80 and over; Anti-Bacterial Agents; Arthritis, Infectious; Conjunctiva; Conjunctival Diseases; Female; Humans; Hyperpigmentation; Minocycline; Sclera; Scleral Diseases

Topics: Administration, Oral; Adult; Choroid Diseases; Conjunctival Diseases; Female; Humans; Kidney Diseases; Lacrimal Apparatus Diseases; Minocycline; Obesity, Morbid; Peptidyl-Dipeptidase A; Sarcoidosis; Sarcoidosis, Pulmonary; Skin Diseases; Tomography, X-Ray Computed

Topics: Acne Vulgaris; Anti-Bacterial Agents; Conjunctival Diseases; Humans; Male; Middle Aged; Minocycline; Pigmentation Disorders; Scleral Diseases

Topics: Aged; Anti-Bacterial Agents; Conjunctival Diseases; Female; Humans; Minocycline; Pigmentation Disorders; Retinal Diseases; Scleral Diseases

Unpigmented and pigmented cystic epithelial inclusions were found bilaterally within the lower palpebral conjunctiva temporally of a 31-year-old man. He had a history of tetracycline/minocycline therapy for 14 years because of acne vulgaris. The cysts were studied by light and electron microscopy, histochemistry, and ultraviolet light. By light microscopy the unpigmented cysts contained faintly eosinophilic globular material that disclosed yellowish-green autofluorescence indicating the presence of tetracycline/minocycline. The pigmented cysts revealed laminated eosinophilic to brownish concretions that also showed yellowish-green autofluorescence. Autofluorescence, however, decreased with increasing brown pigmentation of the concretions. Histochemically, the pigment, which failed to show the staining characteristics of lipofuscin, melanin or iron, probably represented an oxidation product of tetracycline. By electron microscopy the cysts contained moderately electron dense amorphous material as well as degenerating epithelial cells. The epithelial cells lining the conjunctival cysts, did not contain membrane-bound, large, pigment granules within their cytoplasm as has been demonstrated in the colloid and follicular epithelium of the thyroid following minocycline therapy.

Topics: Acne Vulgaris; Adult; Conjunctiva; Conjunctival Diseases; Cysts; Cytoplasmic Granules; Drug Therapy, Combination; Epithelium; Humans; Male; Microscopy, Electron; Minocycline; Tetracycline; Tetracyclines

A 26-year-old man had been treated for acne vulgaris with tetracycline and minocycline orally for 12 years. He developed dark brown to black pigmentary deposits in the palpebral conjunctiva bilaterally. These deposits resembled those seen in epinephrine pigmentation of the conjunctiva. Histologically the pigmented deposits were concretions in conjunctival cysts. Although they contained calcium, the concretions displayed the characteristic yellow autofluorescence of tetracycline under ultraviolet light. Presumably, tetracycline had formed extracellular chelation complexes with calcium, thus accounting for the pigmentation of the conjunctiva.

Topics: Adult; Conjunctival Diseases; Humans; Male; Minocycline; Pigmentation Disorders; Tetracycline; Tetracyclines