minocycline and Cellulitis

A randomized, double-blind, multicenter trial was done to compare two doses of delafloxacin with tigecycline in patients with various complicated skin and skin-structure infections (wound infections following surgery, trauma, burns, or animal/insect bites, abscesses, and cellulitis).. Patients were randomized 1:1:1 to receive delafloxacin 300mg intravenous (IV) every 12h, delafloxacin 450mg IV every 12h, or tigecycline 100mg IV×1, followed by 50mg IV every 12h; randomization was stratified by infection type. Duration of therapy was 5-14 days. The primary efficacy analysis, performed on the clinically evaluable (CE) population at the test-of-cure (TOC) visit (14-21 days after the final dose of study drug), compared clinical response rates in the delafloxacin and tigecycline arms. Clinical response rates in the two delafloxacin arms were also compared.. Among CE patients, clinical cure rates at TOC visit were similar in the delafloxacin and tigecycline arms (94.3%, 92.5%, and 91.2%, respectively in delafloxacin 300-mg, delafloxacin 450-mg, and tigecycline arms). Overall, the most frequent adverse events were nausea, vomiting, and diarrhea; the 300-mg delafloxacin arm was the best-tolerated regimen.. Delafloxacin was similarly effective as tigecycline for a variety of complicated skin and skin-structure infections and was well tolerated. (Clinicaltrials.gov NCT 0719810).

Topics: Abscess; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cellulitis; Double-Blind Method; Female; Fluoroquinolones; Humans; Male; Middle Aged; Minocycline; Tigecycline; Wound Infection; Young Adult

Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Cellulitis; Drug Therapy, Combination; Drugs, Chinese Herbal; Humans; Male; Minocycline; Scalp Dermatoses; Skin Diseases, Genetic; Staphylococcal Skin Infections; Staphylococcus aureus; Staphylococcus epidermidis; Treatment Outcome

Wells syndrome, also known as eosinophilic cellulitis, is an uncommon condition whose etiology often remains a mystery. Patients present with recurrent cutaneous swellings that are often cellulitic in appearance. Histopathologic evaluation of the skin lesions reveals a dense dermal eosinophilic infiltrate, marked edema, and characteristic "flame figures". Notably, the picture is devoid of vasculitis. Therapy with low-dose systemic steroids has proven variably successful. Clinical evidence lending support for the efficacy of other medications has been, for the most part, anecdotal. We present a case of Wells syndrome, review the literature, and discuss therapeutic options.

Topics: Administration, Cutaneous; Administration, Oral; Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents; Cellulitis; Clobetasol; Diagnosis, Differential; Drug Therapy, Combination; Eosinophilia; Female; Humans; Minocycline; Niacinamide; Syndrome

Topics: Aged; Anti-Bacterial Agents; Cellulitis; Eosinophils; Female; Humans; Minocycline

A patient with systemic lupus erythematosus had a protracted skin infection with Mycobacterium marinum after a puffer fish sting. Disseminated cutaneous and synovial disease was associated with clinically active systemic lupus erythematosus two years after the initial infection. The infection was poorly responsive to multiple antituberculous regimens. Hematogenous spread of infection was the likely route of dissemination.

Topics: Adult; Animals; Cellulitis; Female; Fish Venoms; Fishes, Poisonous; Humans; Lupus Erythematosus, Systemic; Minocycline; Mycobacterium Infections; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Skin Diseases, Infectious; Synovitis; Tendinopathy; Wrist

This report describes a patient with a drug reaction and histologic changes of both eosinophilic cellulitis and eosinophilic pustular folliculitis. We propose that some cases of eosinophilic pustular folliculitis, like eosinophilic cellulitis, may occur as a result of a hypersensitivity phenomenon.

Topics: Cellulitis; Drug Eruptions; Eosinophilia; Folliculitis; Humans; Male; Middle Aged; Minocycline

24 patients with severe infections were treated with intravenous minocycline 100 mg every 12 hours. Average blood levels were within therapeutic ranges during the first 12 hours after the initial dose. Determination of efficacy of therapy in 23 of the patients who were evaluable showed that clinical and bacteriological results were satisfactory in 20 patients, unsatisfactory in 2, and questionable in 1. One patient developed a fatal secondary infection which may have been related to prior therapy with minocycline. No toxicities or side-effects were observed.

Topics: Adolescent; Adult; Aged; Bacterial Infections; Cellulitis; Humans; Injections, Intravenous; Middle Aged; Minocycline; Respiratory Tract Infections; Tetracyclines; Urinary Tract Infections