minocycline and Carcinoma

Topics: Adult; Biopsy, Fine-Needle; Carcinoma; Carcinoma, Papillary; Diagnosis, Differential; Female; Humans; Hyperpigmentation; Immunohistochemistry; Minocycline; Thyroid Cancer, Papillary; Thyroid Gland; Thyroid Neoplasms; Thyroid Nodule; Thyroidectomy; Tomography, X-Ray Computed

We report a rare case of black thyroid accompanied by papillary carcinoma in a patient with an extended history of minocycline treatment. A 78-year-old man was referred to our outpatient clinic with swelling in his neck. He had been taking minocycline for the previous 2 years and 7 months to treat chronic perianal pyoderma. Neck ultrasonography and computed tomography demonstrated a 3.5 × 3.7 × 5.0-cm nodule in the left thyroid lobe, and fine-needle aspiration cytology identified it as a papillary carcinoma. The patient underwent a total thyroidectomy and neck dissection. During the procedure, a distinct black discoloration of the thyroid parenchyma was observed. Histopathology confirmed both the black thyroid and the papillary carcinoma. Based on the thyroid gland's discoloration and the history of minocycline use, the patient was diagnosed with minocycline-induced black thyroid. He was symptom-free 20 months after surgery.

Topics: Aged; Anti-Bacterial Agents; Anus Diseases; Carcinoma; Carcinoma, Papillary; Humans; Male; Minocycline; Neck Dissection; Pigmentation Disorders; Pyoderma; Thyroid Cancer, Papillary; Thyroid Diseases; Thyroid Gland; Thyroid Neoplasms; Thyroidectomy; Treatment Outcome

Topics: Aged; Anti-Bacterial Agents; Carcinoma; Colonic Neoplasms; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Minocycline; Paraneoplastic Syndromes; Pyoderma Gangrenosum; Steroids

Topics: Adult; Aged; Carcinoma; Female; Gastrointestinal Neoplasms; Head and Neck Neoplasms; Humans; Lung Neoplasms; Lymph Node Excision; Male; Microbial Sensitivity Tests; Middle Aged; Minocycline; Surgical Wound Infection; Tetracyclines