minocycline and Bacteriuria

To examine the efficacy of bladder catheters impregnated with minocycline and rifampin in reducing catheter-associated bacteriuria.. A prospective, randomized clinical trial was conducted at five academic medical centers. Patients undergoing radical prostatectomy were randomized to receive intraoperatively either regular silicone bladder catheters (control catheters) or silicone bladder catheters impregnated with minocycline and rifampin (antimicrobial-impregnated catheters). Catheters remained in place for a mean of 2 weeks. Urine cultures were obtained at about 3, 7, and 14 days after catheter insertion. Bacteriuria was defined as the growth of organism(s) in urine at a concentration of 10(4) colony-forming units per milliliter or greater.. Kaplan-Meier analysis demonstrated that it took significantly longer for patients (n = 56) who received the antimicrobial-impregnated catheters to develop bacteriuria than those (n = 68) who received the control catheters (P = 0.006 by the log-rank test). Patients who received the antimicrobial-impregnated catheters had significantly lower rates of bacteriuria than those in the control group both at day 7 (15.2% versus 39.7%) and at day 14 (58.5% versus 83.5%) after catheter insertion. Patients who received the antimicrobial-impregnated catheters had significantly lower rates of gram-positive bacteriuria than the control group (7.1% versus 38.2%; P <0.001) but similar rates of gram-negative bacteriuria (46.4% versus 47.1%) and candiduria (3.6% versus 2.9%). The antimicrobial-impregnated catheters provided zones of inhibition against Enterococcus faecalis and Escherichia coli, both at baseline and on removal.. Bladder catheters impregnated with minocycline and rifampin significantly reduced the rate of gram-positive catheter-associated bacteriuria up to 2 weeks after catheter insertion.

Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacteriuria; Equipment Contamination; Humans; Male; Middle Aged; Minocycline; Multivariate Analysis; Prospective Studies; Prostatectomy; Rifampin; Urinary Bladder; Urinary Catheterization

Forty-one hospitalized patients, of whom the majority had asymptomatic bacteriuria, were randomly divided into 4 treatment groups. They were given either tetracycline HCl 1 g, or tetracycline HCl + terpenes 100 mg, or minocycline 200 mg, or cotrimoxazole (sulfamethoxazole 1.6 g + trimethoprim 320 mg), daily for one week. A large number of bacteria were resistant to tetracyclines. The urine was sterilized in 14 out of 24 patients receiving tetracyclines and in all of the 17 patients receiving cotrimoxazole. The mean urinary concentration of tetracycline was 20 times higher than that of minocycline. The 24-h urinary excretion of tetracyclines was slightly higher in patients receiving the combination of terpenes and tetracycline, but these differences in urinary excretion did not appear to have any influence on the antibacterial effect of tetracyclines.

Topics: Adult; Aged; Bacteriuria; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Minocycline; Sulfamethoxazole; Terpenes; Tetracycline; Trimethoprim

Topics: Adult; Aged; Bacteriuria; Female; Humans; Labyrinth Diseases; Male; Meningococcal Infections; Middle Aged; Minocycline; Tetracycline; Tetracyclines

Topics: Anti-Bacterial Agents; Bacteriuria; Drug Resistance, Bacterial; Female; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Minocycline

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasing global threat. Here, we describe the prevalence and impact of tigecycline use in a cohort of patients with CRKP bacteriuria nested within a multicentre, prospective study. In the 21-month study period, 260 unique patients were included. Tigecycline was given to 80 (31%) patients. The use of tigecycline during the index hospitalization was significantly associated with the subsequent development of tigecycline resistance in the same patient (OR, 6.13; 95% CI, 1.15-48.65; p 0.03). In conclusion, the use of tigecycline with CRKP bacteriuria is common, and is associated with the subsequent development of tigecycline resistance.

Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacteriuria; Carbapenems; Cohort Studies; DNA, Bacterial; Drug Resistance, Bacterial; Female; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Middle Aged; Minocycline; Molecular Sequence Data; Sequence Analysis, DNA; Tigecycline

Topics: Anti-Bacterial Agents; Bacteriuria; beta-Lactamases; Drug Resistance, Bacterial; Electrophoresis, Gel, Pulsed-Field; Enterobacteriaceae; Escherichia coli; Humans; Klebsiella pneumoniae; Microbial Sensitivity Tests; Minocycline; Tigecycline

In the course of treating twenty patients with acute urinary tract infections, the toxicity and efficacy of a small dosage regimen (50 mg p.o., t.i.d.) of minocycline were evaluated. No vestibular symptoms attributable to minocycline treatment were observed in any of the cases entered in this study. Adverse reactions included mild nausea in 1 case and urticaria in another case. Minocycline with this dosage regimen sterilized the urine of 90% of patients with acute urinary tract infections.

Topics: Adult; Aged; Bacterial Infections; Bacteriuria; Cystitis; Drug Resistance, Microbial; Female; Humans; Male; Middle Aged; Minocycline; Pyuria; Tetracyclines; Urinary Tract Infections

Topics: Administration, Oral; Bacteriuria; Child; Child, Preschool; Citrobacter; Dosage Forms; Drug Resistance, Microbial; Enterococcus faecalis; Escherichia coli; Hematopoiesis; Humans; Kidney; Klebsiella; Liver; Minocycline; Proteus; Pseudomonas aeruginosa; Tetracyclines; Time Factors; Urinary Tract Infections