minocycline and Abdominal-Pain

Raoultella planticola has been considered a relatively harmless Gram-negative bacteria, rarely associated with clinical infection. However, in recent years, the frequency at which severe infection by R. planticola and drug-resistant strains are reported in literature has increased. Here, we present one case of acute cholecystitis caused by R. planticola, and review all previously reported cases of the infection in an attempt to identify new trends in biological and clinical features of R. planticola infections.

Topics: Abdominal Pain; Aged; Aged, 80 and over; Alcoholism; Anti-Bacterial Agents; Cholecystitis, Acute; Communicable Diseases, Emerging; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Humans; Male; Middle Aged; Minocycline; Tigecycline

In addition to tetracyclines, zinc may constitute an alternative treatment in inflammatory lesions of acne.. To evaluate the place of zinc gluconate in relation to antibiotics in the treatment of acne vulgaris.. Zinc was compared to minocycline in a multicenter randomized double-blind trial. 332 patients received either 30 mg elemental zinc or 100 mg minocycline over 3 months. The primary endpoint was defined as the percentage of the clinical success rate on day 90 (i.e. more than 2/3 decrease in inflammatory lesions, i.e. papules and pustules).. This clinical success rate was 31.2% for zinc and 63.4% for minocycline. Minocycline nevertheless showed a 9% superiority in action at 1 month and one of 17% at 3 months, with respect to the mean change in lesion count. Regarding safety, the majority of the adverse effects of zinc gluconate and of minocycline concerned the gastrointestinal system and were moderate (5 dropouts with zinc gluconate and 4 with minocycline).. Minocycline and zinc gluconate are both effective in the treatment of inflammatory acne, but minocycline has a superior effect evaluated to be 17% in our study.

Topics: Abdominal Pain; Acne Vulgaris; Adolescent; Adult; Anti-Bacterial Agents; Arthralgia; Dermatitis, Seborrheic; Double-Blind Method; Female; Gluconates; Humans; Hypersensitivity; Male; Minocycline; Nausea; Patient Compliance; Patient Dropouts; Patient Satisfaction; Skin; Treatment Outcome; Urticaria; Vomiting; Zinc

► Abdominal pain ► Lower-leg itching ► Dark urine & yellow eyes.

Topics: Abdominal Pain; Acne Vulgaris; Adolescent; Analgesics; Antipruritics; Chemical and Drug Induced Liver Injury; Female; Glucocorticoids; Humans; Immunologic Factors; Minocycline; Mycophenolic Acid; Prednisolone; Pruritus; Treatment Outcome; Urine; White People

Fusobacterium necrophorum is a non-sporulating anaerobic gram negative bacillus and has traditionally been associated with Lemierre's syndrome. The authors report a 34-year-old male who presented to the emergency department with a week's history of dull epigastirc pain. Significant medical history included chronic pancreatitis secondary to alcohol use. The patient had radiological evidence of acute on chronic pancreatitis with thrombosis of the portal vein and multiple intrahepatic abscesses. CT-guided drainage of left upper quadrant revealed fluid collection in the pancreatic bed. The fluid culture grew F necrophorum and the patient was treated with tigecycline for 4 weeks. The patient improved symptomatically and his follow-up computerised axial tomography scan 2 months later showed resolving liver abscess, cavernous transformation of the portal vein and stable findings of chronic pancreatitis. This could represent an infection of the peripancreatic tissue with F necrophorum further leading to pylephlebitis.

Topics: Abdominal Pain; Adult; Anti-Bacterial Agents; Fusobacterium Infections; Fusobacterium necrophorum; Humans; Liver Abscess; Male; Minocycline; Pancreatitis; Portal Vein; Radiography; Tigecycline; Venous Thrombosis

Narcotic bowel syndrome (NBS) is a subset of opioid bowel dysfunctions that results from prolonged treatment with narcotics and is characterized by chronic abdominal pain. NBS is under-recognized and its molecular mechanisms are unknown. We aimed to (1) develop a rat model of NBS and (2) to investigate its peripheral and central neurobiological mechanisms.. Male Wistar rats were given a slow-release emulsion that did or did not contain morphine (10 mg/kg) for 8 days. Visceral sensitivity to colorectal distension (CRD) was evaluated during and after multiple administrations of morphine or vehicle (controls). The effects of minocycline (a microglia inhibitor), nor-binaltorphimine (a kappa-opioid antagonist), and doxantrazole (a mast-cell inhibitor) were observed on morphine-induced visceral hyperalgesia. Levels of OX-42, P-p38 mitogen-activated protein kinase, rat mast cell protease II, and protein gene product 9.5 were assessed at different spinal segments (lumbar 6 to sacral 1) or colonic mucosa by immunohistochemistry.. On day 8 of morphine administration, rats developed visceral hyperalgesia to CRD (incipient response) that lasted for 8 more days (delayed response). Minocycline reduced the incipient morphine-induced hypersensitivity response to CRD whereas nor-binaltorphimine and doxantrazole antagonized the delayed hyperalgesia. Levels of OX-42 and P-p38 increased in the spinal sections, whereas rat mast cell protease II and protein gene product 9.5 increased in the colonic mucosa of rats that were given morphine compared with controls.. We developed a rat model of narcotic bowel-like syndrome and showed that spinal microglia activation mediates the development of morphine-induced visceral hyperalgesia; peripheral neuroimmune activation and spinal dynorphin release represent an important mechanism in the delayed and long-lasting morphine-induced colonic hypersensitivity response to CRD.

Topics: Abdominal Pain; Animals; CD11b Antigen; Chymases; Colon; Delayed-Action Preparations; Disease Models, Animal; Gastrointestinal Transit; Hyperalgesia; Immunohistochemistry; Intestinal Mucosa; Male; Mast Cells; Microglia; Minocycline; Morphine; Naltrexone; Narcotic Antagonists; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Pressure; Rats; Rats, Wistar; Spinal Cord; Syndrome; Thioxanthenes; Time Factors; Ubiquitin Thiolesterase; Xanthones

Topics: Abdominal Pain; Anti-Bacterial Agents; Female; Humans; Middle Aged; Minocycline; Nausea; Pancreatitis; Tigecycline; Vomiting

Topics: Abdominal Pain; Adolescent; Anti-Bacterial Agents; Back Pain; Diagnosis, Differential; Diplopia; Emergency Nursing; Female; Humans; Medical History Taking; Minocycline; Nausea; Nursing Assessment; Physical Examination; Pseudotumor Cerebri