Page last updated: 2024-10-28

miltefosine and Neoplasms

miltefosine has been researched along with Neoplasms in 12 studies

miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin
miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.

Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Research Excerpts

ExcerptRelevanceReference
"In a clinical phase I trial on breast cancer patients with local recurrences, topically applied He-PC resulted in regression of skin metastases."2.38Hexadecylphosphocholine: preclinical and the first clinical results of a new antitumor drug. ( Eibl, H; Unger, C, 1991)
"Hemolysis is a serious side effect of antitumor alkylphospholipids (APLs) that limits dose levels and is a constraint in their use in therapeutic regimen."1.56Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs. ( Gaillard, B; Lebeau, L; Pons, F; Remy, JS, 2020)
"Akt is activated in most human cancers and contributes to cell growth, proliferation and cellular survival pathway."1.39Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines. ( Alam, MM; Joh, EH; Kim, B; Kim, DH; Lee, YS; Park, H, 2013)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (33.33)18.2507
2000's1 (8.33)29.6817
2010's5 (41.67)24.3611
2020's2 (16.67)2.80

Authors

AuthorsStudies
Plano, D1
Baquedano, Y1
Moreno-Mateos, D1
Font, M1
Jiménez-Ruiz, A1
Palop, JA1
Sanmartín, C1
Alam, MM1
Joh, EH1
Park, H1
Kim, B1
Kim, DH1
Lee, YS1
Lin, R1
Elf, S1
Shan, C1
Kang, HB1
Ji, Q1
Zhou, L1
Hitosugi, T1
Zhang, L1
Zhang, S1
Seo, JH1
Xie, J1
Tucker, M1
Gu, TL1
Sudderth, J1
Jiang, L1
Mitsche, M1
DeBerardinis, RJ1
Wu, S1
Li, Y1
Mao, H1
Chen, PR1
Wang, D1
Chen, GZ1
Hurwitz, SJ1
Lonial, S1
Arellano, ML1
Khoury, HJ1
Khuri, FR1
Lee, BH1
Lei, Q1
Brat, DJ1
Ye, K1
Boggon, TJ1
He, C1
Kang, S1
Fan, J1
Chen, J1
Hodon, J1
Borkova, L1
Pokorny, J1
Kazakova, A1
Urban, M1
Gaillard, B1
Remy, JS1
Pons, F1
Lebeau, L1
Li, L1
Yang, M1
Li, C1
Liu, Y1
van Blitterswijk, WJ1
Verheij, M1
Hilgard, P2
Klenner, T1
Stekar, J2
Unger, C3
Grunicke, HH1
Maly, K1
Uberall, F1
Schubert, C1
Kindler, E1
Brachwitz, H1
Eibl, H2

Reviews

6 reviews available for miltefosine and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms;

2015
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research.
    European journal of medicinal chemistry, 2019, Nov-15, Volume: 182

    Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Biomedical Research; Cell Proliferatio

2019
Anticancer mechanisms and clinical application of alkylphospholipids.
    Biochimica et biophysica acta, 2013, Volume: 1831, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane; Endocytosis; Humans; Neoplasms; O

2013
Alkylphosphocholines: a new class of membrane-active anticancer agents.
    Cancer chemotherapy and pharmacology, 1993, Volume: 32, Issue:2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation

1993
[Drug development from phospholipids].
    Onkologie, 2001, Volume: 24 Suppl 1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Clinical Trials as Topic; Drug De

2001
Hexadecylphosphocholine: preclinical and the first clinical results of a new antitumor drug.
    Lipids, 1991, Volume: 26, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Fema

1991

Other Studies

6 other studies available for miltefosine and Neoplasms

ArticleYear
Selenocyanates and diselenides: a new class of potent antileishmanial agents.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:8

    Topics: Aminophenols; Animals; Antiprotozoal Agents; Cell Line, Tumor; Cyanates; Humans; Inhibitory Concentr

2011
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
    Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

    Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans

2013
Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs.
    Pharmaceutical research, 2020, May-27, Volume: 37, Issue:6

    Topics: Administration, Intravenous; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitum

2020
Virtual screening based identification of miltefosine and octenidine as inhibitors of heat shock protein 90.
    Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:11

    Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Down-Regulation;

2021
Cellular signalling as a target in cancer chemotherapy. Phospholipid analogues as inhibitors of mitogenic signal transduction.
    Advances in enzyme regulation, 1996, Volume: 36

    Topics: Antineoplastic Agents; Calcium; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Molecular Structure

1996
New pharmaceuticals: miltefosine.
    Anti-cancer drugs, 1990, Volume: 1, Issue:2

    Topics: Animals; Antineoplastic Agents; Mammary Neoplasms, Experimental; Neoplasms; Phosphorylcholine

1990