miltefosine has been researched along with Neoplasms in 12 studies
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin
miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a clinical phase I trial on breast cancer patients with local recurrences, topically applied He-PC resulted in regression of skin metastases." | 2.38 | Hexadecylphosphocholine: preclinical and the first clinical results of a new antitumor drug. ( Eibl, H; Unger, C, 1991) |
| "Hemolysis is a serious side effect of antitumor alkylphospholipids (APLs) that limits dose levels and is a constraint in their use in therapeutic regimen." | 1.56 | Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs. ( Gaillard, B; Lebeau, L; Pons, F; Remy, JS, 2020) |
| "Akt is activated in most human cancers and contributes to cell growth, proliferation and cellular survival pathway." | 1.39 | Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines. ( Alam, MM; Joh, EH; Kim, B; Kim, DH; Lee, YS; Park, H, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Plano, D | 1 |
| Baquedano, Y | 1 |
| Moreno-Mateos, D | 1 |
| Font, M | 1 |
| Jiménez-Ruiz, A | 1 |
| Palop, JA | 1 |
| Sanmartín, C | 1 |
| Alam, MM | 1 |
| Joh, EH | 1 |
| Park, H | 1 |
| Kim, B | 1 |
| Kim, DH | 1 |
| Lee, YS | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Hodon, J | 1 |
| Borkova, L | 1 |
| Pokorny, J | 1 |
| Kazakova, A | 1 |
| Urban, M | 1 |
| Gaillard, B | 1 |
| Remy, JS | 1 |
| Pons, F | 1 |
| Lebeau, L | 1 |
| Li, L | 1 |
| Yang, M | 1 |
| Li, C | 1 |
| Liu, Y | 1 |
| van Blitterswijk, WJ | 1 |
| Verheij, M | 1 |
| Hilgard, P | 2 |
| Klenner, T | 1 |
| Stekar, J | 2 |
| Unger, C | 3 |
| Grunicke, HH | 1 |
| Maly, K | 1 |
| Uberall, F | 1 |
| Schubert, C | 1 |
| Kindler, E | 1 |
| Brachwitz, H | 1 |
| Eibl, H | 2 |
6 reviews available for miltefosine and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Biomedical Research; Cell Proliferatio | 2019 |
Anticancer mechanisms and clinical application of alkylphospholipids.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Membrane; Endocytosis; Humans; Neoplasms; O | 2013 |
Alkylphosphocholines: a new class of membrane-active anticancer agents.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation | 1993 |
[Drug development from phospholipids].
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Clinical Trials as Topic; Drug De | 2001 |
Hexadecylphosphocholine: preclinical and the first clinical results of a new antitumor drug.
Topics: Adult; Aged; Antineoplastic Agents; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Fema | 1991 |
6 other studies available for miltefosine and Neoplasms
| Article | Year |
|---|---|
Selenocyanates and diselenides: a new class of potent antileishmanial agents.
Topics: Aminophenols; Animals; Antiprotozoal Agents; Cell Line, Tumor; Cyanates; Humans; Inhibitory Concentr | 2011 |
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
Topics: Antineoplastic Agents; Carboxylic Acids; Cell Line, Tumor; Cell Proliferation; Cyclopentanes; Humans | 2013 |
Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs.
Topics: Administration, Intravenous; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitum | 2020 |
Virtual screening based identification of miltefosine and octenidine as inhibitors of heat shock protein 90.
Topics: A549 Cells; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; | 2021 |
Cellular signalling as a target in cancer chemotherapy. Phospholipid analogues as inhibitors of mitogenic signal transduction.
Topics: Antineoplastic Agents; Calcium; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Molecular Structure | 1996 |
New pharmaceuticals: miltefosine.
Topics: Animals; Antineoplastic Agents; Mammary Neoplasms, Experimental; Neoplasms; Phosphorylcholine | 1990 |