miltefosine has been researched along with Extravascular Hemolysis in 19 studies
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin
miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Miltefosine (MFS) is an alkylphosphocholine used for the local treatment of cutaneous metastases of breast cancer and oral therapy of visceral leishmaniasis." | 5.42 | Miltefosine Lipid Nanocapsules for Single Dose Oral Treatment of Schistosomiasis Mansoni: A Preclinical Study. ( Amer, EI; Eissa, MM; El-Azzouni, MZ; El-Khordagui, LK; El-Moslemany, RM; Ramadan, AA, 2015) |
| "Miltefosine was fungicidal for C." | 5.33 | Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis. ( Ellis, DH; Ganendren, R; Handke, R; Obando, D; Sorrell, TC; Widmer, F; Wright, LC, 2006) |
| "Hemolysis is a serious side effect of antitumor alkylphospholipids (APLs) that limits dose levels and is a constraint in their use in therapeutic regimen." | 1.56 | Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs. ( Gaillard, B; Lebeau, L; Pons, F; Remy, JS, 2020) |
| "The toxic effects of miltefosine on the epithelial cells of the gastrointestinal tract and its hemolytic action on erythrocytes have limited its use as an antileishmanial agent." | 1.43 | Miltefosine-loaded lipid nanoparticles: Improving miltefosine stability and reducing its hemolytic potential toward erythtocytes and its cytotoxic effect on macrophages. ( Barioni, MB; da Gama Bitencourt, JJ; de Paula Pinto, C; Guimarães, TH; Ito, AS; Pazin, WM; Santos, MA; Santos, MR; Valduga, CJ, 2016) |
| "Miltefosine (MFS) is an alkylphosphocholine used for the local treatment of cutaneous metastases of breast cancer and oral therapy of visceral leishmaniasis." | 1.42 | Miltefosine Lipid Nanocapsules for Single Dose Oral Treatment of Schistosomiasis Mansoni: A Preclinical Study. ( Amer, EI; Eissa, MM; El-Azzouni, MZ; El-Khordagui, LK; El-Moslemany, RM; Ramadan, AA, 2015) |
| "Miltefosine (MT) is an alkylphospholipid that has been approved for the treatment of breast cancer metastasis and visceral leishmaniasis, although its mechanism of action remains poorly understood." | 1.39 | Interaction of miltefosine with the lipid and protein components of the erythrocyte membrane. ( Alonso, A; Hansen, D; Mendanha, SA; Moreira, RA, 2013) |
| "Miltefosine was fungicidal for C." | 1.33 | Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis. ( Ellis, DH; Ganendren, R; Handke, R; Obando, D; Sorrell, TC; Widmer, F; Wright, LC, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 8 (42.11) | 24.3611 |
| 2020's | 2 (10.53) | 2.80 |
| Authors | Studies |
|---|---|
| Fos, E | 1 |
| Suesa, N | 1 |
| Borras, L | 1 |
| Lobato, C | 1 |
| Banfi, P | 1 |
| Gambetta, RA | 1 |
| Zunino, F | 1 |
| Mauleón, D | 1 |
| Carganico, G | 1 |
| Calogeropoulou, T | 1 |
| Angelou, P | 1 |
| Detsi, A | 1 |
| Fragiadaki, I | 2 |
| Scoulica, E | 2 |
| Esteves, MA | 1 |
| Lopes, R | 1 |
| Cruz, ME | 1 |
| Gaillard, B | 1 |
| Remy, JS | 1 |
| Pons, F | 1 |
| Lebeau, L | 1 |
| Rysin, A | 1 |
| Paal, M | 1 |
| Lokerse, WJM | 1 |
| Wedmann, B | 1 |
| Hossann, M | 1 |
| Vogeser, M | 1 |
| Winter, G | 1 |
| Lindner, LH | 1 |
| Petit, K | 1 |
| Suwalsky, M | 1 |
| Colina, JR | 1 |
| Aguilar, LF | 1 |
| Jemiola-Rzeminska, M | 1 |
| Strzalka, K | 1 |
| Alonso, L | 2 |
| Cardoso, ÉJS | 1 |
| Mendanha, SA | 2 |
| Alonso, A | 3 |
| Moreira, RA | 1 |
| Hansen, D | 1 |
| Munoz, C | 1 |
| Alzoubi, K | 1 |
| Jacobi, J | 1 |
| Abed, M | 1 |
| Lang, F | 1 |
| Eissa, MM | 1 |
| El-Moslemany, RM | 1 |
| Ramadan, AA | 1 |
| Amer, EI | 1 |
| El-Azzouni, MZ | 1 |
| El-Khordagui, LK | 1 |
| da Gama Bitencourt, JJ | 1 |
| Pazin, WM | 1 |
| Ito, AS | 1 |
| Barioni, MB | 1 |
| de Paula Pinto, C | 1 |
| Santos, MA | 1 |
| Guimarães, TH | 1 |
| Santos, MR | 1 |
| Valduga, CJ | 1 |
| Agresta, M | 1 |
| D'Arrigo, P | 1 |
| Fasoli, E | 1 |
| Losi, D | 1 |
| Pedrocchi-Fantoni, G | 1 |
| Riva, S | 1 |
| Servi, S | 1 |
| Tessaro, D | 1 |
| Mravljak, J | 1 |
| Zeisig, R | 2 |
| Pecar, S | 1 |
| Widmer, F | 1 |
| Wright, LC | 1 |
| Obando, D | 1 |
| Handke, R | 1 |
| Ganendren, R | 1 |
| Ellis, DH | 1 |
| Sorrell, TC | 1 |
| Bock, TK | 1 |
| Müller, BW | 1 |
| Kaufmann-Kolle, P | 1 |
| Unger, C | 2 |
| Eibl, H | 2 |
| Kötting, J | 1 |
| Marschner, NW | 1 |
| Neumüller, W | 1 |
| Fichtner, I | 1 |
| Arndt, D | 1 |
| Jungmann, S | 1 |
19 other studies available for miltefosine and Extravascular Hemolysis
| Article | Year |
|---|---|
Synthesis of alkyl chain-modified ether lipids and evaluation of their in vitro cytotoxicity.
Topics: Animals; Cell Division; Cell Survival; Chemical Phenomena; Chemistry, Physical; Growth Inhibitors; H | 1995 |
Design and synthesis of potent antileishmanial cycloalkylidene-substituted ether phospholipid derivatives.
Topics: Animals; Cells, Cultured; Cycloparaffins; Drug Design; Ethers; Hemolysis; Humans; Leishmania; Leishm | 2008 |
Synthesis and biological evaluation of trifluralin analogues as antileishmanial agents.
Topics: Antiprotozoal Agents; Cell Death; Cell Line; Erythrocytes; Hemolysis; Humans; Leishmania; Leishmania | 2010 |
Synthesis and Evaluation of Antitumor Alkylphospholipid Prodrugs.
Topics: Administration, Intravenous; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitum | 2020 |
Evaluation of release and pharmacokinetics of hexadecylphosphocholine (miltefosine) in phosphatidyldiglycerol-based thermosensitive liposomes.
Topics: Animals; Antineoplastic Agents; Calorimetry, Differential Scanning; Chromatography, Liquid; Hemolysi | 2021 |
In vitro effects of the antitumor drug miltefosine on human erythrocytes and molecular models of its membrane.
Topics: Antineoplastic Agents; Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Erythrocy | 2019 |
Interactions of miltefosine with erythrocyte membrane proteins compared to those of ionic surfactants.
Topics: Animals; Antiprotozoal Agents; Bis-Trimethylammonium Compounds; Cattle; Dose-Response Relationship, | 2019 |
Interaction of miltefosine with the lipid and protein components of the erythrocyte membrane.
Topics: Antineoplastic Agents; Antiprotozoal Agents; Erythrocyte Membrane; Hemolysis; Humans; Membrane Lipid | 2013 |
Effect of miltefosine on erythrocytes.
Topics: Anti-Infective Agents; Antineoplastic Agents; Cell Death; Cell Size; Cells, Cultured; Erythrocytes; | 2013 |
Miltefosine Lipid Nanocapsules for Single Dose Oral Treatment of Schistosomiasis Mansoni: A Preclinical Study.
Topics: Administration, Oral; Animals; Antiprotozoal Agents; Drug Evaluation, Preclinical; Hemolysis; Liver; | 2015 |
Hemolytic potential of miltefosine is dependent on cell concentration: Implications for in vitro cell cytotoxicity assays and pharmacokinetic data.
Topics: Erythrocyte Membrane; Hemolysis; Humans; In Vitro Techniques; Phosphorylcholine | 2016 |
Miltefosine-loaded lipid nanoparticles: Improving miltefosine stability and reducing its hemolytic potential toward erythtocytes and its cytotoxic effect on macrophages.
Topics: Animals; Antiprotozoal Agents; Cell Death; Cells, Cultured; Drug Carriers; Drug Stability; Erythrocy | 2016 |
Synthesis and antiproliferative activity of alkylphosphocholines.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; HeLa Cells; Hemolysis; Humans; Inhibitory | 2003 |
Synthesis and biological evaluation of spin-labeled alkylphospholipid analogs.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclic N-Oxides; Drug Screening Assays, Antitumor; Hemolysi | 2005 |
Hexadecylphosphocholine (miltefosine) has broad-spectrum fungicidal activity and is efficacious in a mouse model of cryptococcosis.
Topics: Acyltransferases; Animals; Antifungal Agents; Cryptococcosis; Disease Models, Animal; Enzyme Inhibit | 2006 |
A novel assay to determine the hemolytic activity of drugs incorporated in colloidal carrier systems.
Topics: Colloids; Drug Carriers; Erythrocytes; Hemoglobins; Hemolysis; Humans; In Vitro Techniques; Phosphor | 1994 |
Hexadecylphosphocholine in liposomal dispersions.
Topics: Antineoplastic Agents; Hemolysis; Lipid Bilayers; Liposomes; Phosphorylcholine | 1992 |
Hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine: a comparison of hemolytic activity, serum binding and tissue distribution.
Topics: Animals; Antineoplastic Agents; Female; Hemolysis; Phospholipid Ethers; Phosphorylcholine; Rats; Rat | 1992 |
Antitumor effects of alkylphosphocholines in different murine tumor models: use of liposomal preparations.
Topics: Animals; Antineoplastic Agents; Hemolysis; Humans; Leukemia P388; Liposomes; Mammary Neoplasms, Expe | 1991 |