miltefosine has been researched along with Cystic Fibrosis in 1 studies
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin
miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Miltefosine has structural similarity to the PC and sphingomyelin substrates of PlcHR, and we found that it inhibits the cleavage of these choline-containing lipids in vitro." | 1.37 | Hemolytic phospholipase C inhibition protects lung function during Pseudomonas aeruginosa infection. ( Allard, JL; Allen, GB; Gross, MJ; Hogan, DA; Leclair, LW; Lundblad, LK; Rajamani, S; Vasil, ML; Wargo, MJ, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wargo, MJ | 1 |
| Gross, MJ | 1 |
| Rajamani, S | 1 |
| Allard, JL | 1 |
| Lundblad, LK | 1 |
| Allen, GB | 1 |
| Vasil, ML | 1 |
| Leclair, LW | 1 |
| Hogan, DA | 1 |
1 other study available for miltefosine and Cystic Fibrosis
| Article | Year |
|---|---|
Hemolytic phospholipase C inhibition protects lung function during Pseudomonas aeruginosa infection.
Topics: Animals; Antifungal Agents; Bronchoalveolar Lavage Fluid; Cystic Fibrosis; Disease Models, Animal; H | 2011 |