miltefosine has been researched along with Co-infection in 14 studies
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin
miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " One hundred and fifty patients aged ≥18 years with serologically confirmed HIV and parasitologically confirmed VL were randomly allocated to 1 of 2 treatment arms, either a total 40 mg/kg intravenous liposomal amphotericin B (AmBisome; Gilead Pharmaceuticals) administered in 8 equal doses over 24 days or a total 30 mg/kg intravenous AmBisome administered in 6 equal doses given concomitantly with a total 1." | 5.51 | AmBisome Monotherapy and Combination AmBisome-Miltefosine Therapy for the Treatment of Visceral Leishmaniasis in Patients Coinfected With Human Immunodeficiency Virus in India: A Randomized Open-Label, Parallel-Arm, Phase 3 Trial. ( Alexander, N; Alves, F; Burza, S; Das, P; Das, VNR; de Lima Pereira, A; Gill, N; Goyal, V; Harshana, A; Kazmi, S; Kumar, D; Kumar, V; Lal, CS; Lasry, E; Mahajan, R; Pandey, K; Rewari, B; Rijal, S; Verma, N, 2022) |
| "Embedded in a clinical trial in Northwest Ethiopia, RNA-Seq was performed on whole blood samples of 28 VL-HIV patients before and after completion of a 29-day treatment regimen of AmBisome or AmBisome/miltefosine." | 5.34 | Host transcriptomic signature as alternative test-of-cure in visceral leishmaniasis patients co-infected with HIV. ( Adriaensen, W; Alves, F; Blesson, S; Cnops, L; Cordero, CF; Cuypers, B; Diro, E; Kaye, PM; Mengasha, B; van Griensven, J, 2020) |
| "Miltefosine was extracted from DBS samples using a simple method of pretreatment with methanol, resulting in >97% recovery." | 2.82 | Validation and Clinical Evaluation of a Novel Method To Measure Miltefosine in Leishmaniasis Patients Using Dried Blood Spot Sample Collection. ( Beijnen, JH; Blesson, S; Diro, E; Dorlo, TP; Hailu, A; Hillebrand, MJ; Kip, AE; Mengesha, B; Rosing, H; Schellens, JH, 2016) |
| "Miltefosine is an oral drug which was used as a topical application for skin metastasis of breast cancer." | 1.43 | Pharmacovigilance of Miltefosine in Treatment of Visceral Leishmaniasis in Endemic Areas of Bihar, India. ( Das Gupta, RK; Das, P; Dhariwal, AC; Pandey, K; Ravidas, V; Siddiqui, NA; Singh, TP; Sinha, SK; Verma, RB, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (78.57) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Burza, S | 3 |
| Mahajan, R | 2 |
| Kazmi, S | 1 |
| Alexander, N | 2 |
| Kumar, D | 2 |
| Kumar, V | 1 |
| Lasry, E | 1 |
| Harshana, A | 1 |
| de Lima Pereira, A | 2 |
| Das, P | 3 |
| Verma, N | 1 |
| Das, VNR | 1 |
| Lal, CS | 1 |
| Rewari, B | 1 |
| Goyal, V | 1 |
| Rijal, S | 1 |
| Alves, F | 3 |
| Gill, N | 1 |
| Pandey, K | 3 |
| Zanelli, G | 1 |
| Rossetti, B | 1 |
| Gagliardini, R | 1 |
| Paglicci, L | 1 |
| Tordini, G | 1 |
| Miracco, C | 1 |
| Aversa, S | 1 |
| Zammarchi, L | 1 |
| Di Muccio, T | 1 |
| Gramiccia, M | 1 |
| Montagnani, F | 1 |
| Adriaensen, W | 1 |
| Cuypers, B | 1 |
| Cordero, CF | 1 |
| Mengasha, B | 1 |
| Blesson, S | 3 |
| Cnops, L | 1 |
| Kaye, PM | 1 |
| Diro, E | 5 |
| van Griensven, J | 3 |
| Kassardjian, AA | 1 |
| Yim, KM | 1 |
| Rabi, S | 1 |
| Liang, TZ | 1 |
| Kim, GH | 1 |
| Ochoa, MT | 1 |
| Sattah, MV | 1 |
| Ahronowitz, IZ | 1 |
| Abongomera, C | 1 |
| Buyze, J | 1 |
| Stille, K | 1 |
| Ahmed, F | 1 |
| Ritmeijer, K | 3 |
| Edwards, T | 1 |
| Fikre, H | 1 |
| Admassu, H | 1 |
| Kibret, A | 1 |
| Ellis, SJ | 1 |
| Bardonneau, C | 1 |
| Zijlstra, EE | 1 |
| Soipei, P | 1 |
| Mutinda, B | 1 |
| Omollo, R | 1 |
| Kimutai, R | 1 |
| Omwalo, G | 1 |
| Wasunna, M | 1 |
| Tadesse, F | 1 |
| Strub-Wourgaft, N | 1 |
| Hailu, A | 3 |
| Alvar, J | 1 |
| Patole, S | 1 |
| Varghese, GM | 1 |
| Lynen, L | 1 |
| Boelaert, M | 2 |
| Monge-Maillo, B | 1 |
| López-Vélez, R | 1 |
| Isaakidis, P | 1 |
| Sunyoto, T | 1 |
| Sagili, KD | 1 |
| Lima, MA | 1 |
| Mitra, G | 1 |
| Van Geertruyden, JP | 1 |
| Kip, AE | 1 |
| Rosing, H | 1 |
| Hillebrand, MJ | 1 |
| Mengesha, B | 1 |
| Schellens, JH | 1 |
| Beijnen, JH | 1 |
| Dorlo, TP | 1 |
| Costa, S | 1 |
| Machado, M | 1 |
| Cavadas, C | 1 |
| do Céu Sousa, M | 1 |
| Faucher, JF | 1 |
| Morquin, D | 1 |
| Reynes, J | 1 |
| Chirouze, C | 1 |
| Hoen, B | 1 |
| Le Moing, V | 1 |
| Ravidas, V | 1 |
| Siddiqui, NA | 1 |
| Sinha, SK | 1 |
| Verma, RB | 1 |
| Singh, TP | 1 |
| Dhariwal, AC | 1 |
| Das Gupta, RK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Trial of Ambisome Monotherapy and Combination of Ambisome and Miltefosine for the Treatment of VL in HIV Positive Patients in Ethiopia Followed by Secondary VL Prophylactic Treatment With Pentamidine.[NCT02011958] | Phase 3 | 59 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for miltefosine and Co-infection
| Article | Year |
|---|---|
Diffuse cutaneous leishmaniasis and HIV co-infection: A case report and review of the literature.
Topics: Adult; Amphotericin B; Antiprotozoal Agents; Coinfection; Darier Disease; Drug Therapy, Combination; | 2021 |
Visceral Leishmaniasis and HIV coinfection in East Africa.
Topics: Africa, Eastern; Amphotericin B; Anti-Retroviral Agents; Antiprotozoal Agents; Coinfection; HIV Infe | 2014 |
Miltefosine for visceral and cutaneous leishmaniasis: drug characteristics and evidence-based treatment recommendations.
Topics: Administration, Oral; Africa, Eastern; Antiprotozoal Agents; Bangladesh; Coinfection; Drug Therapy, | 2015 |
4 trials available for miltefosine and Co-infection
| Article | Year |
|---|---|
AmBisome Monotherapy and Combination AmBisome-Miltefosine Therapy for the Treatment of Visceral Leishmaniasis in Patients Coinfected With Human Immunodeficiency Virus in India: A Randomized Open-Label, Parallel-Arm, Phase 3 Trial.
Topics: Adolescent; Adult; Amphotericin B; Antiprotozoal Agents; Coinfection; Drug Therapy, Combination; HIV | 2022 |
Host transcriptomic signature as alternative test-of-cure in visceral leishmaniasis patients co-infected with HIV.
Topics: Adult; Amphotericin B; Antiprotozoal Agents; Coinfection; Endoribonucleases; Female; Gene Expression | 2020 |
A randomized trial of AmBisome monotherapy and AmBisome and miltefosine combination to treat visceral leishmaniasis in HIV co-infected patients in Ethiopia.
Topics: Adult; Amphotericin B; Anti-Retroviral Agents; Antiprotozoal Agents; Coinfection; Drug Therapy, Comb | 2019 |
Validation and Clinical Evaluation of a Novel Method To Measure Miltefosine in Leishmaniasis Patients Using Dried Blood Spot Sample Collection.
Topics: Antiprotozoal Agents; Calibration; Chromatography, Liquid; Coinfection; Dried Blood Spot Testing; Dr | 2016 |
7 other studies available for miltefosine and Co-infection
| Article | Year |
|---|---|
Use of miltefosine in a patient with mucosal leishmaniasis and HIV-coinfection: a challenge in long-term management.
Topics: Coinfection; HIV Infections; Humans; Leishmaniasis, Mucocutaneous; Male; Middle Aged; Phosphorylchol | 2019 |
The initial effectiveness of liposomal amphotericin B (AmBisome) and miltefosine combination for treatment of visceral leishmaniasis in HIV co-infected patients in Ethiopia: A retrospective cohort study.
Topics: Adult; Amphotericin B; Antiprotozoal Agents; Coinfection; Drug Therapy, Combination; Ethiopia; Femal | 2018 |
Multiple relapses of visceral leishmaniasis in a patient with HIV in India: a treatment challenge.
Topics: Adult; Amphotericin B; Antiprotozoal Agents; Antiretroviral Therapy, Highly Active; Coinfection; HIV | 2014 |
Combination Treatment for Visceral Leishmaniasis Patients Coinfected with Human Immunodeficiency Virus in India.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Amphotericin B; Coinfection; D | 2015 |
Antileishmanial activity of antiretroviral drugs combined with miltefosine.
Topics: Alkynes; Animals; Anti-Retroviral Agents; Antiprotozoal Agents; Atazanavir Sulfate; Benzoxazines; Co | 2016 |
Serial use of pentamidine and miltefosine for treating Leishmania infantum-HIV coinfection.
Topics: Antiprotozoal Agents; Coinfection; HIV Infections; Humans; Immunocompromised Host; Leishmania infant | 2016 |
Pharmacovigilance of Miltefosine in Treatment of Visceral Leishmaniasis in Endemic Areas of Bihar, India.
Topics: Administration, Oral; Adolescent; Adult; Aged; Alanine Transaminase; Antiprotozoal Agents; Aspartate | 2016 |