milrinone has been researched along with Shock, Septic in 11 studies
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The median half-life was 1." | 2.69 | Pharmacokinetics and pharmacodynamics of milrinone lactate in pediatric patients with septic shock. ( Barton, P; Garcia, J; Giroir, B; Kitchen, L; Kouatli, A; Lawless, S; Lindsay, CA; Zorka, A, 1998) |
| "milrinone would increase cardiac index by 20% and decrease systemic vascular resistance index by 20% during a 2-h study period." | 2.68 | Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study. ( Barton, P; Garcia, J; Giroir, B; Kitchen, L; Kouatli, A; Lawless, S; Lindsay, C; Zorka, A, 1996) |
| "In non-hyperdynamic septic shock, CI, SVI, and DO₂ significantly increased while SVRI significantly decreased after milrinone when compared to placebo." | 2.47 | The role of milrinone in children with cardiovascular compromise: review of the literature. ( Abdul-Khaliq, H; Brown, K; Gortner, L; Meyer, S, 2011) |
| "A total of 417 patients with septic shock were included, 72 (17." | 1.62 | Effects of Inotropes on the Mortality in Patients With Septic Shock. ( Ariyoshi, N; Crossey, E; Devendra, G; Hamahata, N; Hasegawa, D; Ishihara, T; Nasu, M; Sato, R, 2021) |
| "Hypotension is a common problem in neonates with complex underlying pathophysiology." | 1.46 | Management of Neonatal Hypotension. ( Kalish, BT, 2017) |
| "In milrinone-treated septic animals cardiac index was maintained for a longer period of time but blood pressure was significantly reduced compared with the control pigs." | 1.28 | Lack of beneficial effects of milrinone in severe septic shock. ( Almqvist, P; Andersson, KE; Arvidsson, D; Haglund, U; Lindgren, S; Montgomery, A, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Albertson, TE | 1 |
| Chenoweth, JA | 1 |
| Lewis, JC | 1 |
| Pugashetti, JV | 1 |
| Sandrock, CE | 1 |
| Morrissey, BM | 1 |
| Sato, R | 1 |
| Ariyoshi, N | 1 |
| Hasegawa, D | 1 |
| Crossey, E | 1 |
| Hamahata, N | 1 |
| Ishihara, T | 1 |
| Nasu, M | 1 |
| Devendra, G | 1 |
| McNeilly, RG | 1 |
| Kalish, BT | 1 |
| Meyer, S | 1 |
| Gortner, L | 1 |
| Brown, K | 1 |
| Abdul-Khaliq, H | 1 |
| Liet, JM | 1 |
| Jacqueline, C | 1 |
| Orsonneau, JL | 1 |
| Gras-Leguen, C | 1 |
| Potel, G | 1 |
| Rozé, JC | 1 |
| Johnston, AM | 1 |
| Carr, B | 1 |
| Barton, P | 2 |
| Garcia, J | 2 |
| Kouatli, A | 2 |
| Kitchen, L | 2 |
| Zorka, A | 2 |
| Lindsay, C | 1 |
| Lawless, S | 2 |
| Giroir, B | 2 |
| Lindsay, CA | 1 |
| Kochi, K | 1 |
| Kyo, S | 1 |
| Yokote, Y | 1 |
| Ueda, K | 1 |
| Asano, H | 1 |
| Koyanagi, T | 1 |
| Ohuchi, H | 1 |
| Omoto, R | 1 |
| Lindgren, S | 1 |
| Almqvist, P | 1 |
| Arvidsson, D | 1 |
| Montgomery, A | 1 |
| Andersson, KE | 1 |
| Haglund, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 2- Inhaled Milrinone Prevents the Increase in Pulmonary Artery Pressure After CPB[NCT00819377] | Phase 2 | 124 participants (Anticipated) | Interventional | 2009-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for milrinone and Shock, Septic
| Article | Year |
|---|---|
The pharmacotherapeutic options in patients with catecholamine-resistant vasodilatory shock.
Topics: Angiotensin II; Ascorbic Acid; Cardiotonic Agents; Catecholamines; Cytomegalovirus Infections; Dobut | 2022 |
The role of milrinone in children with cardiovascular compromise: review of the literature.
Topics: Administration, Inhalation; Adolescent; Cardiac Output, Low; Cardiotonic Agents; Child; Child, Presc | 2011 |
2 trials available for milrinone and Shock, Septic
| Article | Year |
|---|---|
Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study.
Topics: Adolescent; Cardiac Output; Child; Child, Preschool; Double-Blind Method; Female; Hemodynamics; Huma | 1996 |
Pharmacokinetics and pharmacodynamics of milrinone lactate in pediatric patients with septic shock.
Topics: Adolescent; Cardiotonic Agents; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method; Ha | 1998 |
7 other studies available for milrinone and Shock, Septic
| Article | Year |
|---|---|
Effects of Inotropes on the Mortality in Patients With Septic Shock.
Topics: Cardiotonic Agents; Dobutamine; Epinephrine; Hospital Mortality; Humans; Milrinone; Retrospective St | 2021 |
Sepsis, venous return, and teleology.
Topics: Algorithms; Blood Pressure; Cardiac Output; Coronary Circulation; Critical Illness; Dihydroergotamin | 2014 |
Management of Neonatal Hypotension.
Topics: Blood Pressure; Cardiotonic Agents; Dobutamine; Dopamine; Ductus Arteriosus, Patent; Humans; Hypoten | 2017 |
The effects of milrinone on hemodynamics in an experimental septic shock model.
Topics: Animals; Dilatation, Pathologic; Disease Models, Animal; Female; Hemodynamics; Hypotension; Milrinon | 2005 |
Community-acquired bacterial meningitis.
Topics: Catheterization, Swan-Ganz; Community-Acquired Infections; Humans; Hypotension; Meningitis, Bacteria | 2006 |
[The effect of milrinone for the shock patients after cardiac surgery].
Topics: Aged; Cardiac Surgical Procedures; Cardiotonic Agents; Coronary Artery Bypass; Female; Heart Valve P | 1999 |
Lack of beneficial effects of milrinone in severe septic shock.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Cardiac Output; Cardiotonic Agents; Escherichia coli I | 1990 |