milrinone has been researched along with Sepsis in 12 studies
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Combination therapy with milrinone and esmolol could improve cardiac function and the 28-day survival rate in patients with severe sepsis." | 9.20 | Combination therapy with milrinone and esmolol for heart protection in patients with severe sepsis: a prospective, randomized trial. ( Guo, J; Nie, X; Wang, Z; Wu, Q; Yang, C, 2015) |
| "To characterize the effect of the phosphodiesterase inhibitor (PDEI) milrinone in adult patients with a non-hyperdynamic condition during the course of the systemic inflammatory response syndrome (SIRS) or sepsis when compared with patients with congestive heart failure (CHF)." | 9.09 | IV milrinone for cardiac output increase and maintenance: comparison in nonhyperdynamic SIRS/sepsis and congestive heart failure. ( Delle Karth, G; Frossard, M; Geppert, A; Gschwandtner, ME; Heinz, G; Neunteufl, T; Reinelt, P; Siostrzonek, P; Zauner, C, 1999) |
| "In addition to the positive inotropic effects of milrinone, its immunomodulatory properties that result in decreased cytokine storm can be beneficial during early period of sepsis." | 8.12 | Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats. ( Bilen, A; Halici, H; Halici, Z; Keskin, H; Kose, D; Mendil, AS; Ozkaraca, M; Tavaci, T; Yuksel, TN, 2022) |
| "Compared with dobutamine, the use of milrinone did not decrease hospital mortality in patients with sepsis." | 8.02 | The effect of dobutamine vs milrinone in sepsis: A big data, real-world study. ( Wei, J; Ye, X; Yin, H; Zhang, R; Zhu, Y, 2021) |
| " We weighed the effects of dobutamine and milrinone as inotropes in mice with cecal ligation and puncture (CLP)-induced polymicrobial sepsis." | 7.85 | Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation. ( Hattori, K; Hattori, Y; Matsuda, N; Palikhe, S; Sakai, M; Suzuki, T; Tomita, K; Yamashita, S; Yoshimura, N, 2017) |
| "Combination therapy with milrinone and esmolol could improve cardiac function and the 28-day survival rate in patients with severe sepsis." | 5.20 | Combination therapy with milrinone and esmolol for heart protection in patients with severe sepsis: a prospective, randomized trial. ( Guo, J; Nie, X; Wang, Z; Wu, Q; Yang, C, 2015) |
| "To characterize the effect of the phosphodiesterase inhibitor (PDEI) milrinone in adult patients with a non-hyperdynamic condition during the course of the systemic inflammatory response syndrome (SIRS) or sepsis when compared with patients with congestive heart failure (CHF)." | 5.09 | IV milrinone for cardiac output increase and maintenance: comparison in nonhyperdynamic SIRS/sepsis and congestive heart failure. ( Delle Karth, G; Frossard, M; Geppert, A; Gschwandtner, ME; Heinz, G; Neunteufl, T; Reinelt, P; Siostrzonek, P; Zauner, C, 1999) |
| "In addition to the positive inotropic effects of milrinone, its immunomodulatory properties that result in decreased cytokine storm can be beneficial during early period of sepsis." | 4.12 | Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats. ( Bilen, A; Halici, H; Halici, Z; Keskin, H; Kose, D; Mendil, AS; Ozkaraca, M; Tavaci, T; Yuksel, TN, 2022) |
| "Compared with dobutamine, the use of milrinone did not decrease hospital mortality in patients with sepsis." | 4.02 | The effect of dobutamine vs milrinone in sepsis: A big data, real-world study. ( Wei, J; Ye, X; Yin, H; Zhang, R; Zhu, Y, 2021) |
| " We weighed the effects of dobutamine and milrinone as inotropes in mice with cecal ligation and puncture (CLP)-induced polymicrobial sepsis." | 3.85 | Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation. ( Hattori, K; Hattori, Y; Matsuda, N; Palikhe, S; Sakai, M; Suzuki, T; Tomita, K; Yamashita, S; Yoshimura, N, 2017) |
| " As treatment, three inotropes commonly used for treatment of cardiac failure were infused for 45 mins in separate animal groups-milrinone, dobutamine, and levosimendan." | 3.74 | Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone. ( Barraud, D; Damy, T; Faivre, V; Gayat, E; Heymes, C; Mebazaa, A; Payen, D; Shah, AM; Welschbillig, S, 2007) |
| "Purpura fulminans is a severe and rapidly progressive septic process characterised by the development of haemorrhagic and ecchymotic lesions and skin necrosis." | 1.51 | Management of purpura fulminans skin lesions in a premature neonate with sepsis: a case study. ( Bosch-Alcaraz, A; Manzano-Canillas, ML; Pérez-Acevedo, G; Torra-Bou, JE, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Kurup, V | 1 |
| Simpson, RS | 1 |
| Keskin, H | 1 |
| Tavaci, T | 1 |
| Halici, H | 1 |
| Yuksel, TN | 1 |
| Ozkaraca, M | 1 |
| Bilen, A | 1 |
| Kose, D | 1 |
| Mendil, AS | 1 |
| Halici, Z | 1 |
| Zhu, Y | 1 |
| Yin, H | 1 |
| Zhang, R | 1 |
| Ye, X | 1 |
| Wei, J | 1 |
| Sakai, M | 2 |
| Suzuki, T | 2 |
| Tomita, K | 2 |
| Yamashita, S | 2 |
| Palikhe, S | 1 |
| Hattori, K | 2 |
| Yoshimura, N | 2 |
| Matsuda, N | 2 |
| Hattori, Y | 2 |
| Iguchi, K | 1 |
| Sakamoto, T | 1 |
| Yokoo, H | 1 |
| Misawa, H | 1 |
| Nagata, T | 1 |
| Watanabe, Y | 1 |
| Pérez-Acevedo, G | 1 |
| Torra-Bou, JE | 1 |
| Manzano-Canillas, ML | 1 |
| Bosch-Alcaraz, A | 1 |
| Wang, Z | 1 |
| Wu, Q | 1 |
| Nie, X | 1 |
| Guo, J | 1 |
| Yang, C | 1 |
| Schmittinger, CA | 1 |
| Dünser, MW | 1 |
| Haller, M | 1 |
| Ulmer, H | 1 |
| Luckner, G | 1 |
| Torgersen, C | 1 |
| Jochberger, S | 1 |
| Hasibeder, WR | 1 |
| Mrabat, H | 1 |
| Beagle, J | 1 |
| Hang, Z | 1 |
| Garg, HG | 1 |
| Hales, CA | 1 |
| Quinn, DA | 1 |
| Rich, N | 1 |
| West, N | 1 |
| McMaster, P | 1 |
| Alexander, J | 1 |
| Barraud, D | 1 |
| Faivre, V | 1 |
| Damy, T | 1 |
| Welschbillig, S | 1 |
| Gayat, E | 1 |
| Heymes, C | 1 |
| Payen, D | 1 |
| Shah, AM | 1 |
| Mebazaa, A | 1 |
| Heinz, G | 1 |
| Geppert, A | 1 |
| Delle Karth, G | 1 |
| Reinelt, P | 1 |
| Gschwandtner, ME | 1 |
| Neunteufl, T | 1 |
| Zauner, C | 1 |
| Frossard, M | 1 |
| Siostrzonek, P | 1 |
2 trials available for milrinone and Sepsis
| Article | Year |
|---|---|
Combination therapy with milrinone and esmolol for heart protection in patients with severe sepsis: a prospective, randomized trial.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Cardiotonic Agents; Drug Therapy, Combination; Female | 2015 |
IV milrinone for cardiac output increase and maintenance: comparison in nonhyperdynamic SIRS/sepsis and congestive heart failure.
Topics: Adult; Aged; Cardiotonic Agents; Female; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Mil | 1999 |
10 other studies available for milrinone and Sepsis
| Article | Year |
|---|---|
Sepsis-induced digital ischaemia in a professional pianist, in the absence of vasopressors.
Topics: Adult; Amputation, Surgical; Anticoagulants; Diagnosis, Differential; Fingers; Gangrene; Heparin; Hu | 2019 |
Early administration of milrinone ameliorates lung and kidney injury during sepsis in juvenile rats.
Topics: Animals; Disease Models, Animal; Kidney; Ligation; Lung; Milrinone; Punctures; Rats; Sepsis | 2022 |
The effect of dobutamine vs milrinone in sepsis: A big data, real-world study.
Topics: Big Data; Cardiotonic Agents; Dobutamine; Humans; Milrinone; Retrospective Studies; Sepsis | 2021 |
Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation.
Topics: Adenylyl Cyclases; Animals; Cardiotonic Agents; Cecum; Cyclic AMP; Cyclic Nucleotide Phosphodiestera | 2017 |
Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis.
Topics: Animals; Calcium; Cardiotonic Agents; Cecum; Cytokines; Ligation; Male; Mice, Inbred BALB C; Milrino | 2018 |
Management of purpura fulminans skin lesions in a premature neonate with sepsis: a case study.
Topics: Debridement; Diagnosis, Differential; Female; Humans; Infant, Newborn; Infant, Premature; Infusions, | 2019 |
Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression.
Topics: Aged; Aged, 80 and over; Cardiomyopathies; Drug Therapy, Combination; Female; Humans; Male; Metoprol | 2008 |
Inhibition of HA synthase 3 mRNA expression, with a phosphodiesterase 3 inhibitor, blocks lung injury in a septic ventilated rat model.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Capillary Permea | 2009 |
Milrinone in meningococcal sepsis.
Topics: Child; Humans; Intensive Care Units, Pediatric; Leg; Meningococcal Infections; Milrinone; Phosphodie | 2003 |
Levosimendan restores both systolic and diastolic cardiac performance in lipopolysaccharide-treated rabbits: comparison with dobutamine and milrinone.
Topics: Animals; Cardiotonic Agents; Diastole; Disease Models, Animal; Dobutamine; Heart Failure; Hydrazones | 2007 |