milrinone has been researched along with Myocardial Ischemia in 29 studies
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Postoperatively, the patient had persistent sinus tachycardia that was initially unsuccessfully treated with metoprolol." | 7.70 | Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998) |
| "Cilostazol (Pletal), a quinolinone derivative with a cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitory activity, was recently approved by the Food and Drug Administration for treatment of symptoms of intermittent claudication (IC)." | 7.70 | Inhibition of adenosine uptake and augmentation of ischemia-induced increase of interstitial adenosine by cilostazol, an agent to treat intermittent claudication. ( Cone, J; Fong, M; Kambayashi, J; Liu, Y; Wang, S; Yoshitake, M, 2000) |
| " Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat." | 7.68 | Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993) |
| "Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography." | 5.29 | Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts. ( Blazincic, B; Klaus, W; Rump, AF, 1993) |
| "Serum levels of creatine phosphokinase (CPK), the MB isoenzyme of creatine kinase (CK-MB), occurrence of myocardial ischemia or infarction, and mean duration of using inotropic agents were significantly lower in the milrinone group (p < 0." | 5.14 | Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: A randomized controlled trial. ( Darehzereshki, A; Dianat, S; Eghtesadi-Araghi, P; Ghazinoor, M; Goodarzynejad, H; Jebeli, M; Mandegar, MH; Mohammadzadeh, R; Rasouli, MR, 2010) |
| " 1) Milrinone decreased incidence of myocardial ischemia and myocardial infarction (15." | 4.93 | Effect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials. ( Cheng, X; Huang, L; Jiang, X; Wu, Q; Wu, Y; You, Z, 2016) |
| "We report a 23-month old girl who presented with bilateral epiphora who underwent bilateral lacrimal probing and syringing, during which a cocaine adrenaline solution was used." | 3.81 | Myocardial ischaemia following cocaine and adrenaline exposure in a child during an ophthalmological procedure. ( McGovern, E; McMahon, CJ; Moylett, E, 2015) |
| "To evaluate: 1) the effects of dobutamine (DOB) on left ventricular function in early (48-72 h) and late (14 days) phases of a post-MI canine model, compared to ISTA, and 2) the efficacy of DOB in chronic left ventricular dysfunction (6 months post-MI) in dogs pre-treated or not with a beta-blocker, compared with ISTA and milrinone (MIL)." | 3.74 | Sympathomimetic inefficiency in restoring contractility in the acute or chronic beta-blocker-treated ischaemic heart: comparison with a new agent. ( Borsini, F; Carminati, P; Gagnol, JP; Loi, FM; Mattera, GG; Vanoli, E, 2008) |
| " Postoperatively, the patient had persistent sinus tachycardia that was initially unsuccessfully treated with metoprolol." | 3.70 | Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998) |
| "Cilostazol (Pletal), a quinolinone derivative with a cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitory activity, was recently approved by the Food and Drug Administration for treatment of symptoms of intermittent claudication (IC)." | 3.70 | Inhibition of adenosine uptake and augmentation of ischemia-induced increase of interstitial adenosine by cilostazol, an agent to treat intermittent claudication. ( Cone, J; Fong, M; Kambayashi, J; Liu, Y; Wang, S; Yoshitake, M, 2000) |
| " Flosequinan, milrinone, isoprenaline and forskolin given intravenously at similarly hypotensive doses have been evaluated in separate studies for their effect on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content following coronary artery ligation in the pentobarbitone anaesthetized rat." | 3.68 | Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. ( Dickinson, K; Foster, GA; Frodsham, G; Jones, RB, 1993) |
| "Myocardial ischemia was induced by left coronary artery branch occlusion and quantitated from epicardial NADH-fluorescence photography." | 1.29 | Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts. ( Blazincic, B; Klaus, W; Rump, AF, 1993) |
| "Milrinone was then administered to group 3 (n = 7); group 4 (n = 8) served as ischemically injured controls." | 1.29 | Ischemia-dependent efficacy of phosphodiesterase inhibition. ( Burns, PG; Caldarone, CA; Gaudette, GR; Krukenkamp, IB; Levitsky, S; Misare, BD, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (41.38) | 18.2507 |
| 2000's | 10 (34.48) | 29.6817 |
| 2010's | 7 (24.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Axelsson, B | 2 |
| Johansson, G | 2 |
| Abrahamsson, P | 1 |
| Gupta, A | 2 |
| Tydén, H | 2 |
| Wouters, P | 2 |
| Haney, M | 2 |
| Hadadzadeh, M | 1 |
| Hosseini, SH | 1 |
| Mostafavi Pour Manshadi, SM | 1 |
| Naderi, N | 1 |
| Emami Meybodi, M | 1 |
| McGovern, E | 1 |
| Moylett, E | 1 |
| McMahon, CJ | 1 |
| You, Z | 1 |
| Huang, L | 1 |
| Cheng, X | 1 |
| Wu, Q | 1 |
| Jiang, X | 1 |
| Wu, Y | 1 |
| Häggmark, S | 1 |
| Svenmarker, S | 1 |
| Mattera, GG | 1 |
| Vanoli, E | 1 |
| Gagnol, JP | 1 |
| Loi, FM | 1 |
| Borsini, F | 1 |
| Carminati, P | 1 |
| Hein, M | 1 |
| Roehl, AB | 1 |
| Baumert, JH | 1 |
| Scherer, K | 1 |
| Steendijk, P | 1 |
| Rossaint, R | 1 |
| Yamaguchi, A | 1 |
| Tanaka, M | 1 |
| Naito, K | 1 |
| Kimura, C | 1 |
| Kobinata, T | 1 |
| Okamura, H | 1 |
| Ino, T | 1 |
| Adachi, H | 1 |
| Jebeli, M | 1 |
| Ghazinoor, M | 1 |
| Mandegar, MH | 1 |
| Rasouli, MR | 1 |
| Eghtesadi-Araghi, P | 1 |
| Goodarzynejad, H | 1 |
| Mohammadzadeh, R | 1 |
| Darehzereshki, A | 1 |
| Dianat, S | 1 |
| Kato, M | 1 |
| Hirayama, A | 1 |
| Möllhoff, T | 1 |
| Schmidt, C | 1 |
| Van Aken, H | 1 |
| Berendes, E | 1 |
| Buerkle, H | 1 |
| Marmann, P | 1 |
| Reinbold, T | 1 |
| Prenger-Berninghoff, R | 1 |
| Tjan, TD | 1 |
| Scheld, HH | 1 |
| Deng, MC | 1 |
| Kim, JH | 1 |
| Ham, BM | 1 |
| Kim, YL | 1 |
| Bahk, JH | 1 |
| Ryu, HG | 1 |
| Jeon, YS | 1 |
| Kim, KB | 1 |
| De Luca, L | 1 |
| Proietti, P | 1 |
| Palombaro, GL | 1 |
| Battagliese, A | 1 |
| Celotto, A | 1 |
| Bucciarelli Ducci, C | 1 |
| Fedele, F | 1 |
| Sablotzki, A | 1 |
| Starzmann, W | 1 |
| Scheubel, R | 1 |
| Grond, S | 1 |
| Czeslick, EG | 1 |
| Use, T | 1 |
| Makita, T | 1 |
| Ureshino, H | 1 |
| Cho, S | 1 |
| Yoshitomi, O | 1 |
| Akiyama, D | 1 |
| Oshibuchi, M | 1 |
| Hara, T | 1 |
| Sumikawa, K | 1 |
| Pridjian, AK | 2 |
| Frohlich, ED | 1 |
| VanMeter, CH | 2 |
| McFadden, PM | 2 |
| Ochsner, JL | 2 |
| Rump, AF | 2 |
| Acar, D | 1 |
| Klaus, W | 2 |
| Jones, RB | 1 |
| Frodsham, G | 1 |
| Dickinson, K | 1 |
| Foster, GA | 1 |
| Blazincic, B | 1 |
| Caldarone, CA | 1 |
| Krukenkamp, IB | 1 |
| Burns, PG | 1 |
| Misare, BD | 1 |
| Gaudette, GR | 1 |
| Levitsky, S | 1 |
| Zhang, YI | 1 |
| Ritchie, RH | 2 |
| Horowitz, JD | 2 |
| Ishisu, R | 1 |
| Abe, Y | 1 |
| Onishi, K | 1 |
| Ueda, Y | 1 |
| Sekioka, K | 1 |
| Nakano, T | 1 |
| Chung, KC | 1 |
| Touchard, CL | 1 |
| Ishikawa, M | 1 |
| Koga, K | 1 |
| Fujiki, H | 1 |
| Mori, T | 1 |
| Yabuuchi, Y | 1 |
| Alhashemi, JA | 1 |
| Hooper, J | 1 |
| Hii, JT | 1 |
| Liu, Y | 1 |
| Fong, M | 1 |
| Cone, J | 1 |
| Wang, S | 1 |
| Yoshitake, M | 1 |
| Kambayashi, J | 1 |
| Carceles, MD | 1 |
| Aleixandre, F | 1 |
| Fuente, T | 1 |
| López-Vidal, J | 1 |
| Laorden, ML | 1 |
| Van de Water, A | 1 |
| Xhonneux, R | 1 |
| Reneman, RS | 1 |
| Janssen, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute and Chronic Protective Effects of Peri-interventional Administration of Levosimendan in ST Elevation Myocardial Infarctions[NCT03022877] | 0 participants (Actual) | Interventional | 2017-06-30 | Withdrawn (stopped due to Rationale obsolete) | |||
| 2- Inhaled Milrinone Prevents the Increase in Pulmonary Artery Pressure After CPB[NCT00819377] | Phase 2 | 124 participants (Anticipated) | Interventional | 2009-02-28 | Completed | ||
| Study of the Efficacy and Safety of Cilostazol in the Prevention of Ischemic Vascular Events in Diabetic Patients With Symptomatic Peripheral Artery Disease.[NCT02983214] | Phase 4 | 826 participants (Actual) | Interventional | 2016-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for milrinone and Myocardial Ischemia
| Article | Year |
|---|---|
Effect of milrinone on cardiac functions in patients undergoing coronary artery bypass graft: a meta-analysis of randomized clinical trials.
Topics: Cardiotonic Agents; Coronary Artery Bypass; Humans; Intensive Care Units; Length of Stay; Milrinone; | 2016 |
[Combination therapy; dobutamine and milrinone].
Topics: Cardiomyopathy, Dilated; Cardiotonic Agents; Dobutamine; Drug Therapy, Combination; Heart Failure; H | 2011 |
New positive inotropic agents in the treatment of left ventricular dysfunction.
Topics: Cardiotonic Agents; Diastole; Heart Failure; Humans; Hydrazones; Milrinone; Myocardial Ischemia; Pho | 2004 |
6 trials available for milrinone and Myocardial Ischemia
| Article | Year |
|---|---|
Effect of milrinone on short term outcome of patients with myocardial dysfunction undergoing off-pump coronary artery bypass graft: a randomized clinical trial.
Topics: Aged; Cardiotonic Agents; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle | 2013 |
Effect of milrinone on short-term outcome of patients with myocardial dysfunction undergoing coronary artery bypass graft: A randomized controlled trial.
Topics: Aged; Cardiotonic Agents; Coronary Artery Bypass; Creatine Kinase; Creatine Kinase, MB Form; Drug Ad | 2010 |
Myocardial ischaemia in patients with impaired left ventricular function undergoing coronary artery bypass grafting--milrinone versus nifedipin.
Topics: Aged; Anesthesia, General; Calcium Channel Blockers; Coronary Artery Bypass; Coronary Disease; Creat | 2002 |
Prophylactic milrinone during OPCAB of posterior vessels: implication in angina patients taking beta-blockers.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Aged; Angina Pectoris; Cardiotonic | 2003 |
Selective pulmonary vasodilation with inhaled aerosolized milrinone in heart transplant candidates.
Topics: Adult; Aerosols; Blood Volume; Cardiomyopathy, Dilated; Extravascular Lung Water; Heart Transplantat | 2005 |
Postextrasystolic potentiation in patients with ischaemic heart disease: influence of inotropic agents.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Cardiac Complexes, Premature; Cardiotonic Agents; Female; | 1995 |
20 other studies available for milrinone and Myocardial Ischemia
| Article | Year |
|---|---|
Milrinone and levosimendan during porcine myocardial ischemia -- no effects on calcium overload and metabolism.
Topics: Animals; Calcium; Calcium Radioisotopes; Cardiotonic Agents; Drug Evaluation, Preclinical; Energy Me | 2013 |
Myocardial ischaemia following cocaine and adrenaline exposure in a child during an ophthalmological procedure.
Topics: Administration, Topical; Anesthetics, Local; Cardiovascular Agents; Cocaine; Diagnostic Techniques, | 2015 |
Effects of Combined Milrinone and Levosimendan Treatment on Systolic and Diastolic Function During Postischemic Myocardial Dysfunction in a Porcine Model.
Topics: Animals; Cardiotonic Agents; Diastole; Disease Models, Animal; Drug Therapy, Combination; Hydrazones | 2016 |
Sympathomimetic inefficiency in restoring contractility in the acute or chronic beta-blocker-treated ischaemic heart: comparison with a new agent.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cardiotonic Agents; Dobutamine; Dogs | 2008 |
Anti-ischemic effects of inotropic agents in experimental right ventricular infarction.
Topics: Animals; Blood Gas Analysis; Cardiotonic Agents; Dobutamine; Female; Heart Ventricles; Hemodynamics; | 2009 |
The efficacy of intravenous milrinone in left ventricular restoration.
Topics: Aged; Cardiac Surgical Procedures; Cardiomyopathies; Cardiopulmonary Bypass; Cardiotonic Agents; Com | 2009 |
Milrinone administered before ischemia or just after reperfusion, attenuates myocardial stunning in anesthetized swine.
Topics: Anesthesia; Animals; Cardiotonic Agents; Female; Male; Milrinone; Myocardial Contraction; Myocardial | 2006 |
Pharmacologic support with high-energy phosphate preservation in the postischemic neonatal heart.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Animals, Newborn; Cardiotonic Agents; Cyclic A | 1995 |
A quantitative comparison of functional and anti-ischaemic effects of the phosphodiesterase-inhibitors, amrinone, milrinone and levosimendan in rabbit isolated hearts.
Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Electric Stimulation; Heart; Heart Rate | 1994 |
Effect of flosequinan on ischaemia-induced arrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressu | 1993 |
Effect of amrinone and milrinone on myocardial ischemia extent and infarct size in isolated rabbit hearts.
Topics: Amrinone; Animals; Cardiotonic Agents; Coronary Circulation; Fluorescence; Hemodynamics; Histocytoch | 1993 |
Ischemia-dependent efficacy of phosphodiesterase inhibition.
Topics: Animals; Cardiotonic Agents; Female; Male; Milrinone; Myocardial Contraction; Myocardial Ischemia; M | 1994 |
Changes in calcium transient and left ventricular function during positive inotropic stimulation and myocardial ischemia in indo-1-loaded beating guinea pig heart.
Topics: Animals; Calcium; Cardiotonic Agents; Digoxin; Fluorescent Dyes; Guinea Pigs; Indoles; Male; Milrino | 1996 |
Repletion of high energy phosphates in the postischemic neonatal heart.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Cardiac Output; Cardiotonic Agents; Cyclic AMP; D | 1996 |
Comparative study of toborinone (OPC-18790) and milrinone on energy metabolism in microembolized guinea pig hearts.
Topics: Animals; Cardiotonic Agents; Energy Metabolism; Guinea Pigs; Heart; Male; Milrinone; Myocardial Isch | 1997 |
Treatment of milrinone-associated tachycardia with beta-blockers.
Topics: Adrenergic beta-Antagonists; Aged; Anesthesia, Epidural; Anesthesia, General; Anti-Arrhythmia Agents | 1998 |
Relationship between myocardial milrinone content and its acute hemodynamic and electrophysiologic effects.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Hemodynamics; Humans; Male; Middle Aged; Milrinon | 1998 |
Inhibition of adenosine uptake and augmentation of ischemia-induced increase of interstitial adenosine by cilostazol, an agent to treat intermittent claudication.
Topics: Adenosine; Animals; Blood Pressure; Cilostazol; Dose-Response Relationship, Drug; Heart Rate; Humans | 2000 |
Combined phosphodiesterase inhibition and beta-blockade in the GI104313, decreases ischemia-induced arrhythmias in the rat.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Hemodynamics; Ma | 2001 |
Cardiac and hemodynamic effects of intravenous R80122, a new phosphodiesterase III inhibitor, in a canine model of myocardial ischemia and heart failure.
Topics: Animals; Blood Pressure; Cardiac Output, Low; Dogs; Female; Heart Rate; Hemodynamics; Imidazoles; In | 1992 |