milrinone has been researched along with Muscle Relaxation in 13 studies
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to elucidate the effects of milrinone, a PDE III inhibitor, on d-tubocurarine (dTc)-induced muscle relaxation in vitro and then to compare its effects with those of other activators of the adenylate cyclase (AC) system (aminophylline, a non-selective PDE inhibitor; forskolin, a direct AC activator; and isoproterenol, a beta-adrenoceptor agonist)." | 3.70 | Milrinone, a phosphodiesterase III inhibitor, antagonizes the neuromuscular blocking effect of a non-depolarizing muscle relaxant in vitro. ( Aimono, M; Fujimura, N; Iwasaki, H; Nakayama, Y; Namiki, A; Narimatsu, E, 1999) |
| " The here obtained pharmacodynamic profiles of the drugs suggest that both milrinone and theophylline may be considered as potent relaxing agents of the lower oesophageal sphincter." | 1.35 | Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit. ( Batzias, GC; Koutsoviti-Papadopoulou, M; Psarra, TA, 2009) |
| "1% when administered intravenously at 30 microg/kg to the chronically hypoxic rats and had an apparent oral bioavailability of about 19." | 1.31 | 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. ( Adachi, H; Ishibashi, K; Ishihara, H; Kabasawa, Y; Kakiki, M; Kodama, K; Matsukura, M; Miyazaki, K; Nishino, M; Ozaki, H; Takase, Y; Watanabe, N, 2000) |
| "Diltiazem was the most potent airway relaxant, and amrinone was less potent in these experiments." | 1.31 | Comparative effect of amrinone, aminophylline and diltiazem on rat airway smooth muscle. ( Kiyota, T; Matsuda, F; Sadohara, T; Sugahara, K; Sugita, M; Terasaki, H, 2000) |
| "Levosimendan is a pyridazinone-dinitrile derivative belonging to a new class of cardiac inotropic drugs, Ca++ sensitizers." | 1.30 | Levosimendan, a calcium sensitizer in cardiac muscle, induces relaxation in coronary smooth muscle through calcium desensitization. ( Bowman, P; Haikala, H; Paul, RJ, 1999) |
| "When OPC 3911 or milrinone was combined with rolipram more than additive effects on aortic relaxation and cAMP content were obtained." | 1.28 | Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta. ( Andersson, KE; Degerman, E; Lindgren, S; Manganiello, V; Rascón, A, 1991) |
| "Milrinone was more potent as a vasorelaxant in coronary arteries relative to cerebral or renal arteries regardless of the mode of contraction; amrinone was coronary selective with K+ contraction only." | 1.28 | Differential vasorelaxant effects of milrinone and amrinone on contractile responses of canine coronary, cerebral, and renal arteries. ( Alousi, AA; Evans, DB; Grant, AM; Harris, AL; Silver, PJ, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davey, DD | 1 |
| Erhardt, PW | 1 |
| Cantor, EH | 1 |
| Greenberg, SS | 1 |
| Ingebretsen, WR | 1 |
| Wiggins, J | 1 |
| Watanabe, N | 1 |
| Adachi, H | 1 |
| Takase, Y | 1 |
| Ozaki, H | 1 |
| Matsukura, M | 1 |
| Miyazaki, K | 1 |
| Ishibashi, K | 1 |
| Ishihara, H | 1 |
| Kodama, K | 1 |
| Nishino, M | 1 |
| Kakiki, M | 1 |
| Kabasawa, Y | 1 |
| Dünnes, S | 1 |
| Voussen, B | 1 |
| Aue, A | 1 |
| Groneberg, K | 1 |
| Nikolaev, V | 1 |
| Groneberg, D | 1 |
| Friebe, A | 1 |
| Koutsoviti-Papadopoulou, M | 1 |
| Psarra, TA | 1 |
| Batzias, GC | 1 |
| Birowo, P | 1 |
| Uckert, S | 1 |
| Kedia, GT | 1 |
| Sonnenberg, JE | 1 |
| Sandner, P | 1 |
| Thon, WF | 1 |
| Scheller, F | 1 |
| Rahardjo, D | 1 |
| Kuczyk, MA | 1 |
| Tasatargil, A | 1 |
| Sadan, G | 1 |
| Ozdem, SS | 1 |
| Planquois, JM | 1 |
| Ruffin-Morin, Y | 1 |
| Lagente, V | 1 |
| Payne, AN | 1 |
| Dahl, SG | 1 |
| Bowman, P | 1 |
| Haikala, H | 1 |
| Paul, RJ | 1 |
| Narimatsu, E | 1 |
| Nakayama, Y | 1 |
| Aimono, M | 1 |
| Fujimura, N | 1 |
| Iwasaki, H | 1 |
| Namiki, A | 1 |
| Matsuda, F | 1 |
| Sugahara, K | 1 |
| Sugita, M | 1 |
| Sadohara, T | 1 |
| Kiyota, T | 1 |
| Terasaki, H | 1 |
| Lindgren, S | 1 |
| Rascón, A | 1 |
| Andersson, KE | 1 |
| Manganiello, V | 1 |
| Degerman, E | 1 |
| Heesen, BJ | 1 |
| De Mey, JG | 1 |
| Harris, AL | 1 |
| Grant, AM | 1 |
| Silver, PJ | 1 |
| Evans, DB | 1 |
| Alousi, AA | 1 |
13 other studies available for milrinone and Muscle Relaxation
| Article | Year |
|---|---|
Novel compounds possessing potent cAMP and cGMP phosphodiesterase inhibitory activity. Synthesis and cardiovascular effects of a series of imidazo[1,2-a]quinoxalinones and imidazo[1,5-a]quinoxalinones and their aza analogues.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aza Compounds; Ca | 1991 |
4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antihypertensive Agents; Biological Availability; Bloo | 2000 |
Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase.
Topics: Animals; Aorta; Blood Platelets; Blood Pressure; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotid | 2018 |
Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit.
Topics: Animals; Bronchodilator Agents; Esophageal Sphincter, Lower; Female; Male; Milrinone; Muscle Relaxat | 2009 |
Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Aged; Colforsin; Cyclic AMP; Cyclic GMP; Drug Evalua | 2010 |
The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Animals; Argini | 2003 |
Salbutamol potentiates the relaxant effects of selective phosphodiesterase inhibitors on guinea pig isolated trachea.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Albuterol; Animals; Drug S | 1996 |
Levosimendan, a calcium sensitizer in cardiac muscle, induces relaxation in coronary smooth muscle through calcium desensitization.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium; Cardiotonic Agents; Coronary Vessels; Cyclic | 1999 |
Milrinone, a phosphodiesterase III inhibitor, antagonizes the neuromuscular blocking effect of a non-depolarizing muscle relaxant in vitro.
Topics: Adrenergic beta-Agonists; Aminophylline; Animals; Colforsin; Diaphragm; Drug Interactions; Electric | 1999 |
Comparative effect of amrinone, aminophylline and diltiazem on rat airway smooth muscle.
Topics: Acetylcholine; Adrenergic beta-Agonists; Aminophylline; Amrinone; Animals; Bronchodilator Agents; Ca | 2000 |
Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Aorta; Cyclic AMP; Cyclic GMP; Drug Interaction | 1991 |
Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Arteries; Buclades | 1990 |
Differential vasorelaxant effects of milrinone and amrinone on contractile responses of canine coronary, cerebral, and renal arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amrinone; Animals; Cerebral Arte | 1989 |