milrinone has been researched along with Muscle Contraction in 21 studies
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We wished to provide comparative information regarding the direct effects of flosequinan, a novel quinolone under development for treating heart failure, on isolated human arterial, venous, and cardiac muscle." | 7.69 | Assessment of flosequinan's direct effect on human arterial, venous, and cardiac muscle: comparison with other classes of agents used to treat heart failure. ( Britton, LW; Ferraris, VA; Kiser, LM; Sim, MF; Wallace, AM; Weishaar, RE, 1994) |
| "Milrinone was injected intracisternally (0." | 5.36 | Effect of vasodilation by milrinone, a phosphodiesterase III inhibitor, on vasospastic arteries after a subarachnoid hemorrhage in vitro and in vivo: effectiveness of cisternal injection of milrinone. ( Date, I; Hishikawa, T; Iseda, K; Manabe, H; Nishiguchi, M; Ono, S, 2010) |
| "We wished to provide comparative information regarding the direct effects of flosequinan, a novel quinolone under development for treating heart failure, on isolated human arterial, venous, and cardiac muscle." | 3.69 | Assessment of flosequinan's direct effect on human arterial, venous, and cardiac muscle: comparison with other classes of agents used to treat heart failure. ( Britton, LW; Ferraris, VA; Kiser, LM; Sim, MF; Wallace, AM; Weishaar, RE, 1994) |
| "Milrinone was injected intracisternally (0." | 1.36 | Effect of vasodilation by milrinone, a phosphodiesterase III inhibitor, on vasospastic arteries after a subarachnoid hemorrhage in vitro and in vivo: effectiveness of cisternal injection of milrinone. ( Date, I; Hishikawa, T; Iseda, K; Manabe, H; Nishiguchi, M; Ono, S, 2010) |
| "If milrinone or SNP was added as a pretreatment, using the EC50 values, the inhibitory effect of milrinone on phenylephrine-induced contractions was greater in arteries than in veins (71 +/- 4 vs." | 1.29 | Vasorelaxant properties of isolated human internal mammary arteries and saphenous veins: comparative effects of milrinone and sodium nitroprusside. ( Dimitri, WR; Dominiczak, AF; Hamilton, CA; Reid, JL; Thorin-Trescases, N, 1993) |
| "When OPC 3911 or milrinone was combined with rolipram more than additive effects on aortic relaxation and cAMP content were obtained." | 1.28 | Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta. ( Andersson, KE; Degerman, E; Lindgren, S; Manganiello, V; Rascón, A, 1991) |
| "Pretreatment with milrinone more than doubled the mean time to fatigue (10." | 1.27 | Effects of milrinone on contractility of the rat diaphragm in vitro. ( Miller, MJ; Rossing, TH; Shannon, K, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 11 (52.38) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agren, P | 1 |
| van der Sterren, S | 1 |
| Cogolludo, AL | 1 |
| Blanco, CE | 1 |
| Villamor, E | 1 |
| Fong, M | 1 |
| Yoshitake, M | 1 |
| Kambayashi, J | 1 |
| Liu, Y | 1 |
| Nishiguchi, M | 1 |
| Ono, S | 1 |
| Iseda, K | 1 |
| Manabe, H | 1 |
| Hishikawa, T | 1 |
| Date, I | 1 |
| Birk, S | 1 |
| Edvinsson, L | 1 |
| Olesen, J | 1 |
| Kruuse, C | 1 |
| Kaneda, T | 2 |
| Shimizu, K | 2 |
| Urakawa, N | 2 |
| Nakajyo, S | 2 |
| Watanabe, A | 1 |
| Saitoh, Y | 1 |
| Thorin-Trescases, N | 1 |
| Dimitri, WR | 1 |
| Dominiczak, AF | 1 |
| Hamilton, CA | 1 |
| Reid, JL | 1 |
| Drescher, P | 1 |
| Eckert, RE | 1 |
| Madsen, PO | 1 |
| Weishaar, RE | 1 |
| Wallace, AM | 1 |
| Kiser, LM | 1 |
| Ferraris, VA | 1 |
| Britton, LW | 1 |
| Sim, MF | 1 |
| Planquois, JM | 1 |
| Ruffin-Morin, Y | 1 |
| Lagente, V | 1 |
| Payne, AN | 1 |
| Dahl, SG | 1 |
| Fujii, Y | 3 |
| Takahashi, S | 3 |
| Toyooka, H | 3 |
| Lindgren, S | 1 |
| Rascón, A | 1 |
| Andersson, KE | 1 |
| Manganiello, V | 1 |
| Degerman, E | 1 |
| Heesen, BJ | 1 |
| De Mey, JG | 1 |
| Resnick, MS | 1 |
| Maitland, LA | 1 |
| Morgan, KG | 1 |
| Wu, PF | 1 |
| Stone, TW | 1 |
| Paton, DM | 1 |
| Rossing, TH | 2 |
| Shannon, K | 1 |
| Miller, MJ | 1 |
| Drazen, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Milrinone in Addition to Hyperdynamic Therapy in the Treatment of Vasospasm Following Aneurysmal Subarachnoid Hemorrhage[NCT02712788] | Phase 2 | 4 participants (Actual) | Interventional | 2016-04-18 | Terminated (stopped due to Completion not feasible due to lack of eligible subjects.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reported as number for each subject and then will look statistically to see if there is a difference between the active arm and the placebo arm. The Modified Rankin scale is Scored as follows: 0 = No symptoms, 1 = No significant disability. Able to carry out all usual activities, despite some symptoms, 2 = Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities, 3 = Moderate disability. Requires some help, but able to walk unassisted, 4 = Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted, 5 = Severe disability. Requires constant nursing care and attention, bedridden, incontinent, 6 = Death. Higher scores indicate worse outcome. (NCT02712788)
Timeframe: 6 months
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | 1.5 |
Reported as number for each subject and then will look statistically to see if there is a difference between the active arm and the placebo arm. THe Modified Rankin Scale is Scored as follows: 0 = No symptoms, 1 = No significant disability. Able to carry out all usual activities, despite some symptoms, 2 = Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities, 3 = Moderate disability. Requires some help, but able to walk unassisted, 4 = Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted, 5 = Severe disability. Requires constant nursing care and attention, bedridden, incontinent, 6 = Death. Higher scores indicate worse outcome. (NCT02712788)
Timeframe: 12 months
| Intervention | score on a scale (Mean) |
|---|---|
| Placebo | 2 |
1 review available for milrinone and Muscle Contraction
| Article | Year |
|---|---|
Drugs to facilitate recovery of neuromuscular blockade and muscle strength.
Topics: Amino Acids; Anesthesia Recovery Period; Animals; Body Temperature Regulation; Humans; Milrinone; Mu | 2005 |
20 other studies available for milrinone and Muscle Contraction
| Article | Year |
|---|---|
Developmental changes in the effects of prostaglandin E2 in the chicken ductus arteriosus.
Topics: Age Factors; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Chick Embryo; C | 2009 |
Cilostazol increases tissue blood flow in contracting rabbit gastrocnemius muscle.
Topics: Adenosine; AMP Deaminase; Animals; Cilostazol; Dose-Response Relationship, Drug; Electric Stimulatio | 2010 |
Effect of vasodilation by milrinone, a phosphodiesterase III inhibitor, on vasospastic arteries after a subarachnoid hemorrhage in vitro and in vivo: effectiveness of cisternal injection of milrinone.
Topics: Angiography; Animals; Basilar Artery; Cyclic AMP; Disease Models, Animal; Dogs; Female; Injections, | 2010 |
Analysis of the effects of phosphodiesterase type 3 and 4 inhibitors in cerebral arteries.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Cyclic Nucl | 2004 |
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in guinea pig taenia coli.
Topics: Adenine; Animals; Carbachol; Colforsin; Colon; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, D | 2004 |
Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adenine; Animals; Carbachol; Cyclic AMP; Cyclic GMP; | 2005 |
Vasorelaxant properties of isolated human internal mammary arteries and saphenous veins: comparative effects of milrinone and sodium nitroprusside.
Topics: Aged; Coronary Artery Bypass; Female; Humans; Male; Mammary Arteries; Middle Aged; Milrinone; Muscle | 1993 |
Smooth muscle contractility in prostatic hyperplasia: role of cyclic adenosine monophosphate.
Topics: Bucladesine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Humans; Male; Milrinone; Muscl | 1994 |
Assessment of flosequinan's direct effect on human arterial, venous, and cardiac muscle: comparison with other classes of agents used to treat heart failure.
Topics: Captopril; Diltiazem; Heart Failure; Humans; In Vitro Techniques; Milrinone; Muscle Contraction; Mus | 1994 |
Salbutamol potentiates the relaxant effects of selective phosphodiesterase inhibitors on guinea pig isolated trachea.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adrenergic beta-Agonists; Albuterol; Animals; Drug S | 1996 |
The effects of milrinone and its mechanism in the fatigued diaphragm in dogs.
Topics: Animals; Blood Pressure; Diaphragm; Dogs; Hemodynamics; In Vitro Techniques; Milrinone; Muscle Contr | 1998 |
The effect of olprinone compared with milrinone on diaphragmatic muscle function in dogs.
Topics: Animals; Blood Pressure; Cardiac Output; Diaphragm; Dogs; Heart Rate; Imidazoles; Milrinone; Muscle | 1999 |
Milrinone enhances the contractility of fatigued diaphragm in dogs: a dose-ranging study.
Topics: Animals; Diaphragm; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Hemodynami | 1999 |
Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Aorta; Cyclic AMP; Cyclic GMP; Drug Interaction | 1991 |
Effects of cyclic AMP-affecting agents on contractile reactivity of isolated mesenteric and renal resistance arteries of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Arteries; Buclades | 1990 |
Flosequinan, a vasodilator with a novel mechanism of action.
Topics: Aequorin; Animals; Aorta, Thoracic; Calcium; Ferrets; In Vitro Techniques; Male; Milrinone; Muscle C | 1991 |
[Change in pulmonary artery and aorta reactions of isobaric hypoxic pulmonary hypertension in guinea-pig and milrinone's effect].
Topics: Animals; Aorta; Female; Guinea Pigs; Hypertension, Pulmonary; Hypoxia; Male; Milrinone; Muscle Contr | 1991 |
Actions of amrinone and milrinone on the guinea-pig ileum.
Topics: Amrinone; Animals; Evoked Potentials; Female; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Mil | 1988 |
Effects of milrinone on contractility of the rat diaphragm in vitro.
Topics: Animals; Diaphragm; Dose-Response Relationship, Drug; Electric Stimulation; Indomethacin; Isometric | 1987 |
Effects of milrinone on contractile responses of guinea pig trachea, lung parenchyma and pulmonary artery.
Topics: Aminophylline; Animals; Carbachol; Cardiotonic Agents; Dose-Response Relationship, Drug; Guinea Pigs | 1986 |