milrinone has been researched along with Hypoxia in 16 studies
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There is little information regarding the comparative hemodynamic effects of adding milrinone or levosimendan to dopamine infusion in hypoxia-reoxygenated (H-R) newborns." | 7.78 | Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine. ( Bigam, DL; Cheung, PY; Churchill, T; Joynt, C; Manouchehri, N; Vento, M, 2012) |
| " We examined the dose-response of milrinone on systemic, pulmonary, and carotid circulations in a model of neonatal hypoxia-reoxygenation." | 7.74 | Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation. ( Bigam, DL; Charrois, G; Cheung, PY; Jewell, LD; Joynt, C; Korbutt, G, 2008) |
| "There is little information regarding the comparative hemodynamic effects of adding milrinone or levosimendan to dopamine infusion in hypoxia-reoxygenated (H-R) newborns." | 3.78 | Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine. ( Bigam, DL; Cheung, PY; Churchill, T; Joynt, C; Manouchehri, N; Vento, M, 2012) |
| " In a swine model of neonatal hypoxia-reoxygenation, effects of epinephrine, dobutamine and milrinone on systemic, pulmonary and regional hemodynamics and oxygen transport were compared." | 3.76 | Milrinone, dobutamine or epinephrine use in asphyxiated newborn pigs resuscitated with 100% oxygen. ( Bigam, DL; Charrois, G; Cheung, PY; Jewell, LD; Joynt, C; Korbutt, G, 2010) |
| " We examined the dose-response of milrinone on systemic, pulmonary, and carotid circulations in a model of neonatal hypoxia-reoxygenation." | 3.74 | Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation. ( Bigam, DL; Charrois, G; Cheung, PY; Jewell, LD; Joynt, C; Korbutt, G, 2008) |
| " Milrinone, a phosphodiesterase (PDE)-3 inhibitor, is frequently used to treat perioperative pulmonary hypertension." | 3.73 | Zaprinast attenuates hypoxic pulmonary artery injury and causes less aortic relaxation than milrinone. ( Crisostomo, P; Kher, A; Meldrum, DR; Pitcher, JM; Tsai, BM; Wang, M, 2005) |
| "Milrinone, a therapeutic agent for acute congestive heart failure, has both inotropic and vasodilatory effects, but investigations of these effects of milrinone were almost all conducted under normoxia, and few reports have investigated how milrinone affects the hemodynamics and redistribution of regional blood flow under severe hypoxia." | 3.71 | Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dog. ( Fujiki, M; Misumi, K; Miura, N; Ota, H; Sakamoto, H; Setoyama, K, 2002) |
| "Milrinone and 6-bromo-8(methylamino)imidazo[1,2a]pyrazine-2-carbonitrile [SCA40; phosphodiesterase (PDE) III inhibitors], zaprinast (PDE V inhibitor), and 3-isobutyl-1-methyl xanthine (IBMX; nonselective PDE inhibitor) were examined on main pulmonary arteries from control rats and rats exposed to hypoxia (10% O2; 1 or 4 weeks) to induce pulmonary hypertension." | 3.70 | Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension. ( Jeffery, TK; Wanstall, JC, 1998) |
| "It is therefore important to avoid both hypoxemia and hyperoxemia in the management of PPHN." | 2.53 | Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates. ( Konduri, GG; Lakshminrusimha, S; Steinhorn, RH, 2016) |
| "Only milrinone treated patients with HIE/TH had a marked drop in DAP in the first hour, which persisted for more than 12 h despite escalation in inotropes (p = 0." | 1.62 | Hemodynamic response to milrinone for refractory hypoxemia during therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy. ( Bischoff, AR; Giesinger, RE; Habib, S; McNamara, PJ, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Mandell, E | 1 |
| Kinsella, JP | 1 |
| Abman, SH | 1 |
| Bischoff, AR | 1 |
| Habib, S | 1 |
| McNamara, PJ | 1 |
| Giesinger, RE | 1 |
| Lakshminrusimha, S | 1 |
| Konduri, GG | 1 |
| Steinhorn, RH | 1 |
| Kamamoto, H | 1 |
| Joynt, C | 3 |
| Bigam, DL | 3 |
| Charrois, G | 2 |
| Jewell, LD | 2 |
| Korbutt, G | 2 |
| Cheung, PY | 3 |
| Manouchehri, N | 1 |
| Churchill, T | 1 |
| Vento, M | 1 |
| Setoyama, K | 1 |
| Ota, H | 1 |
| Miura, N | 1 |
| Fujiki, M | 1 |
| Misumi, K | 1 |
| Sakamoto, H | 1 |
| Rohlicek, CV | 1 |
| Viau, S | 1 |
| Trieu, P | 1 |
| Hébert, TE | 1 |
| Bassler, D | 1 |
| Choong, K | 1 |
| McNamara, P | 1 |
| Kirpalani, H | 1 |
| Tsai, BM | 1 |
| Wang, M | 1 |
| Pitcher, JM | 1 |
| Kher, A | 1 |
| Crisostomo, P | 1 |
| Meldrum, DR | 1 |
| Webster, KA | 1 |
| Bodi, I | 1 |
| McNamara, JP | 1 |
| Tracy, M | 1 |
| Discher, DJ | 1 |
| Bishopric, NH | 1 |
| Jeffery, TK | 1 |
| Wanstall, JC | 1 |
| Kato, R | 1 |
| Sato, J | 1 |
| Nishino, T | 1 |
| Wu, PF | 1 |
| Sys, SU | 1 |
| Goenen, MJ | 1 |
| Chalant, CH | 1 |
| Brutsaert, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness of Nebulized Magnesium Sulfate Combined With Sildenafil Citrate in Persistent Pulmonary Hypertension of Newborn[NCT04898114] | Phase 1/Phase 2 | 40 participants (Anticipated) | Interventional | 2021-06-02 | Recruiting | ||
| Does Closed-loop Automated Oxygen Control During Mechanical Ventilation Reduce Hypoxic Events? A Randomised Controlled Crossover Study in Ventilated Infants[NCT05017727] | 31 participants (Actual) | Observational | 2021-10-05 | Completed | |||
| Does Closed-loop Automated Oxygen Control During Mechanical Ventilation Reduce the Duration of Supplementary Oxygen Treatment and the Amount of Time Spent in Hyperoxia? A Randomised Trial in Ventilated Infants Born at or Near Term[NCT05657795] | 40 participants (Anticipated) | Interventional | 2022-12-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for milrinone and Hypoxia
| Article | Year |
|---|---|
Persistent pulmonary hypertension of the newborn.
Topics: Bosentan; Epoprostenol; Humans; Hypertension, Pulmonary; Hypoxia; Infant; Infant, Newborn; Infant, P | 2021 |
Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates.
Topics: Administration, Inhalation; Animals; Extracorporeal Membrane Oxygenation; Humans; Hyperoxia; Hypoxia | 2016 |
Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates.
Topics: Administration, Inhalation; Animals; Extracorporeal Membrane Oxygenation; Humans; Hyperoxia; Hypoxia | 2016 |
Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates.
Topics: Administration, Inhalation; Animals; Extracorporeal Membrane Oxygenation; Humans; Hyperoxia; Hypoxia | 2016 |
Considerations in the management of hypoxemic respiratory failure and persistent pulmonary hypertension in term and late preterm neonates.
Topics: Administration, Inhalation; Animals; Extracorporeal Membrane Oxygenation; Humans; Hyperoxia; Hypoxia | 2016 |
14 other studies available for milrinone and Hypoxia
| Article | Year |
|---|---|
Hemodynamic response to milrinone for refractory hypoxemia during therapeutic hypothermia for neonatal hypoxic ischemic encephalopathy.
Topics: Hemodynamics; Humans; Hypothermia, Induced; Hypoxia; Hypoxia-Ischemia, Brain; Infant, Newborn; Milri | 2021 |
[The effect of PDEIII inhibitors and colforsin daropate on hypoxic pulmonary vasoconstriction in rabbit lungs].
Topics: Animals; Colforsin; Hypoxia; Imidazoles; In Vitro Techniques; Male; Milrinone; Phosphodiesterase Inh | 2008 |
Milrinone, dobutamine or epinephrine use in asphyxiated newborn pigs resuscitated with 100% oxygen.
Topics: Animals; Animals, Newborn; Bronchodilator Agents; Cardiotonic Agents; Dobutamine; Epinephrine; Femal | 2010 |
Milrinone is preferred to levosimendan for mesenteric perfusion in hypoxia-reoxygenated newborn piglets treated with dopamine.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Dopamine; Drug Therapy, Combination; Hemodynamics; Hy | 2012 |
Effects of milrinone on hemodynamics and regional blood flow in the hypoxic dog.
Topics: Animals; Blood Pressure; Cerebellum; Dogs; Heart Rate; Hemodynamics; Hypoxia; Kidney; Milrinone; Myo | 2002 |
Effects of neonatal hypoxia in the rat on inotropic stimulation of the adult heart.
Topics: Adrenergic beta-Antagonists; Animals; Animals, Newborn; Body Weight; Cardiotonic Agents; Dobutamine; | 2005 |
Neonatal persistent pulmonary hypertension treated with milrinone: four case reports.
Topics: Administration, Inhalation; Animals; Female; Gestational Age; Humans; Hypoxia; Infant, Newborn; Infa | 2006 |
Zaprinast attenuates hypoxic pulmonary artery injury and causes less aortic relaxation than milrinone.
Topics: Animals; Aorta; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Synergism; Hypertension, Pul | 2005 |
Dose-response effects of milrinone on hemodynamics of newborn pigs with hypoxia-reoxygenation.
Topics: Animals; Animals, Newborn; Blood Pressure; Dose-Response Relationship, Drug; Hemodynamics; Hypoxia; | 2008 |
Negative lusitropy and abnormal calcium handling in hypoxic cardiac myocytes exposed to the calcium-sensitizer EMD 53998.
Topics: Animals; Calcium; Cardiotonic Agents; Cells, Cultured; Dose-Response Relationship, Drug; Guinea Pigs | 1993 |
Phosphodiesterase III and V inhibitors on pulmonary artery from pulmonary hypertensive rats: differences between early and established pulmonary hypertension.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1998 |
Milrinone decreases both pulmonary arterial and venous resistances in the hypoxic dog.
Topics: Animals; Dogs; Hemodynamics; Hypoxia; Milrinone; Oxygen; Partial Pressure; Phosphodiesterase Inhibit | 1998 |
[Change in pulmonary artery and aorta reactions of isobaric hypoxic pulmonary hypertension in guinea-pig and milrinone's effect].
Topics: Animals; Aorta; Female; Guinea Pigs; Hypertension, Pulmonary; Hypoxia; Male; Milrinone; Muscle Contr | 1991 |
Inotropic effects of amrinone and milrinone on contraction and relaxation of isolated cardiac muscle.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Aminopyridines; Amrinone; Animals; Calcium; Cardiotonic Agents; | 1986 |