Page last updated: 2024-10-31

milrinone and Hypotension

milrinone has been researched along with Hypotension in 34 studies

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"To determine the effect of milrinone on induced hypotension during spinal surgery in elderly patients."9.19The effect of milrinone on induced hypotension in elderly patients during spinal surgery: a randomized controlled trial. ( Hwang, W; Kim, E, 2014)
" We hypothesized that vasopressin could recover hypotension induced by milrinone with less effect on pulmonary vascular resistance (PVR) compared to norepinephrine."9.12Comparative hemodynamic effects of vasopressin and norepinephrine after milrinone-induced hypotension in off-pump coronary artery bypass surgical patients. ( Bahk, JH; Choi, JY; Jeon, Y; Kim, CS; Lim, YJ; Ryu, JH; Yoon, SZ, 2006)
"Hypotension is an adverse event that may be related to systemic exposure of milrinone; however, the true exposure-safety relationship is unknown."8.12The relationship between simulated milrinone exposure and hypotension in children. ( Balevic, SJ; Cohen-Wolkowiez, M; Commander, SJ; Gonzalez, D; Hornik, CP; Kumar, KR; Spears, T; Zimmerman, KO, 2022)
" Postoperatively, the patient had persistent sinus tachycardia that was initially unsuccessfully treated with metoprolol."7.70Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998)
"Vasopressin at very low doses appears to be an effective vasopressor for milrinone-induced hypotension."7.70Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension. ( Chen, J; Cullinane, S; Gold, JA; Landry, DW; Oliver, JA; Oz, MC, 2000)
"The use of phosphodiesterase inhibitors such as milrinone in the treatment of severe heart failure is frequently restricted because they cause vasodilation and hypotension."7.70Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure. ( Chen, J; Cullinane, S; Gold, J; Landry, DW; Oliver, JA; Oz, MC; Seo, S, 2000)
" Patients were maintained on milrinone therapy for as long as 8 weeks and demonstrated a low incidence of adverse cardiac (7%) or noncardiac (4%) events."6.68Safety and clinical utility of long-term intravenous milrinone in advanced heart failure. ( Kapoor, C; Mehra, MR; Smart, FW; Stapleton, DD; Ventura, HO; Zimmerman, D, 1997)
"Milrinone is a phosphodiesterase type III inhibitor with positive inotropic and vasodilatory effects."5.31Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis. ( Ewald, G; Mindel, G; Saab, G; Vijayan, A, 2002)
"To determine the effect of milrinone on induced hypotension during spinal surgery in elderly patients."5.19The effect of milrinone on induced hypotension in elderly patients during spinal surgery: a randomized controlled trial. ( Hwang, W; Kim, E, 2014)
" We hypothesized that vasopressin could recover hypotension induced by milrinone with less effect on pulmonary vascular resistance (PVR) compared to norepinephrine."5.12Comparative hemodynamic effects of vasopressin and norepinephrine after milrinone-induced hypotension in off-pump coronary artery bypass surgical patients. ( Bahk, JH; Choi, JY; Jeon, Y; Kim, CS; Lim, YJ; Ryu, JH; Yoon, SZ, 2006)
"Hypotension is an adverse event that may be related to systemic exposure of milrinone; however, the true exposure-safety relationship is unknown."4.12The relationship between simulated milrinone exposure and hypotension in children. ( Balevic, SJ; Cohen-Wolkowiez, M; Commander, SJ; Gonzalez, D; Hornik, CP; Kumar, KR; Spears, T; Zimmerman, KO, 2022)
"Population pharmacokinetic modeling and simulations suggest a slow loading dose followed by maintenance infusion to reach therapeutic milrinone plasma concentrations within the timeframe of the postligation cardiac syndrome."3.91Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants. ( Hallik, M; Ilmoja, ML; Jalas, T; Kipper, K; Metsvaht, T; Raidmäe, M; Standing, JF; Starkopf, J; Takkis, K; Tasa, T; Uibo, K; Veigure, R, 2019)
" Postoperatively, the patient had persistent sinus tachycardia that was initially unsuccessfully treated with metoprolol."3.70Treatment of milrinone-associated tachycardia with beta-blockers. ( Alhashemi, JA; Hooper, J, 1998)
"Vasopressin at very low doses appears to be an effective vasopressor for milrinone-induced hypotension."3.70Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension. ( Chen, J; Cullinane, S; Gold, JA; Landry, DW; Oliver, JA; Oz, MC, 2000)
"The use of phosphodiesterase inhibitors such as milrinone in the treatment of severe heart failure is frequently restricted because they cause vasodilation and hypotension."3.70Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure. ( Chen, J; Cullinane, S; Gold, J; Landry, DW; Oliver, JA; Oz, MC; Seo, S, 2000)
"Milrinone was associated with a higher incidence of sinus bradycardia (D = 2%, M = 13%; p < 0."2.70Comparison of the hemodynamic effects of milrinone with dobutamine in patients after cardiac surgery. ( Feneck, RO; Oduro-Dominah, A; Sherry, KM; Withington, PS, 2001)
" Patients were maintained on milrinone therapy for as long as 8 weeks and demonstrated a low incidence of adverse cardiac (7%) or noncardiac (4%) events."2.68Safety and clinical utility of long-term intravenous milrinone in advanced heart failure. ( Kapoor, C; Mehra, MR; Smart, FW; Stapleton, DD; Ventura, HO; Zimmerman, D, 1997)
"Milrinone has been suggested as a possible first-line therapy for preterm neonates to prevent postligation cardiac syndrome (PLCS) through decreasing systemic vascular resistance and increasing cardiac contractility."1.46Dosing of Milrinone in Preterm Neonates to Prevent Postligation Cardiac Syndrome: Simulation Study Suggests Need for Bolus Infusion. ( Hallik, M; Metsvaht, T; Starkopf, J; Tasa, T, 2017)
"Hypotension is a common problem in neonates with complex underlying pathophysiology."1.46Management of Neonatal Hypotension. ( Kalish, BT, 2017)
" We identified adverse events (AEs) during milrinone exposure."1.42Safety of milrinone use in neonatal intensive care units. ( Brian Smith, P; Clark, RH; Hornik, CP; McHutchison, K; Raman, SR; Samiee-Zafarghandy, S; van den Anker, JN, 2015)
"The echocardiographic presence of mild aortic regurgitation combined with left ventricular hypocontractility in a structurally normal heart should alert the physician to the presence of underlying hypertension."1.39Neonatal circulatory failure due to acute hypertensive crisis: clinical and echocardiographic clues. ( Allegaert, K; Brown, S; Cools, B; Eyskens, B; Gewillig, M; Heying, R; Levtchenko, E; Louw, J; Smits, A; Thewissen, L, 2013)
" Beta-blocker dosages were titrated, and three patients achieved the target beta-blocker dosage established for stage A-C heart failure."1.34Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone. ( Earl, GL; Fitzpatrick, JM; Narula, J; Verbos-Kazanas, MA, 2007)
"Milrinone is a phosphodiesterase type III inhibitor with positive inotropic and vasodilatory effects."1.31Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis. ( Ewald, G; Mindel, G; Saab, G; Vijayan, A, 2002)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (11.76)18.2507
2000's14 (41.18)29.6817
2010's14 (41.18)24.3611
2020's2 (5.88)2.80

Authors

AuthorsStudies
Phad, N1
de Waal, K1
Commander, SJ1
Gonzalez, D1
Kumar, KR1
Spears, T1
Cohen-Wolkowiez, M1
Zimmerman, KO1
Balevic, SJ1
Hornik, CP2
Elhassan, A1
Essandoh, M1
Hallik, M2
Ilmoja, ML1
Tasa, T2
Standing, JF1
Takkis, K1
Veigure, R1
Kipper, K1
Jalas, T1
Raidmäe, M1
Uibo, K1
Starkopf, J2
Metsvaht, T2
Dempsey, E1
Rabe, H1
Qin, H1
Jiang, W1
EL-Khuffash, A1
McNamara, PJ1
Lapointe, A1
Jain, A1
Louw, J1
Brown, S1
Thewissen, L1
Smits, A1
Eyskens, B1
Heying, R1
Cools, B1
Levtchenko, E1
Allegaert, K1
Gewillig, M1
Hwang, W1
Kim, E1
Samiee-Zafarghandy, S1
Raman, SR1
van den Anker, JN1
McHutchison, K1
Clark, RH1
Brian Smith, P1
Meyer, S1
Tagawa, M1
Nanba, H1
Suzuki, H1
Nakamura, Y1
Uchiyama, H1
Ochiai, S1
Terunuma, M1
Yahata, K1
Minamino, T1
Kalish, BT1
Cuevas Valenzuela, P1
Rufino Ruiz, J1
Palacios Blanco, E1
Toth-Heyn, P1
Cataldi, L1
Saab, G1
Mindel, G1
Ewald, G1
Vijayan, A1
Smull, DL1
Jorde, UP1
Liet, JM1
Jacqueline, C1
Orsonneau, JL1
Gras-Leguen, C1
Potel, G1
Rozé, JC1
Seri, I2
Noori, S1
Osborn, DA1
Johnston, AM1
Carr, B1
Jeon, Y1
Ryu, JH1
Lim, YJ1
Kim, CS1
Bahk, JH1
Yoon, SZ1
Choi, JY1
Lange, M1
Van Aken, H1
Westphal, M1
Mayr, V1
Luckner, G1
Jochberger, S1
Wenzel, V1
Ulmer, H1
Pajk, W1
Knotzer, H1
Friesenecker, B1
Lindner, K1
Hasibeder, W1
Dünser, M1
Earl, GL1
Verbos-Kazanas, MA1
Fitzpatrick, JM1
Narula, J1
Shubert, J1
Mancano, MA1
Pina, IL1
Milfred, SK1
Mehra, MR1
Ventura, HO1
Kapoor, C1
Stapleton, DD1
Zimmerman, D1
Smart, FW1
Alhashemi, JA1
Hooper, J1
Orime, Y1
Shiono, M1
Hata, H1
Yagi, S1
Tsukamoto, S1
Okumura, H1
Kimura, S1
Hata, M1
Sezai, A1
Obana, M1
Sezai, Y1
Gold, JA1
Cullinane, S2
Chen, J2
Oz, MC2
Oliver, JA2
Landry, DW2
Gold, J1
Seo, S1
Feneck, RO1
Sherry, KM1
Withington, PS1
Oduro-Dominah, A1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Levosimendan Administration in High Risk Cardiac Surgery Patients With Pulmonary Hypertension[NCT04599816]45 participants (Actual)Interventional2020-10-17Completed
Comparison of Intravenous Levosimendan and Inhalational Milrinone in High Risk Cardiac Patients With Pulmonary Hypertension[NCT04718350]40 participants (Anticipated)Interventional2021-01-27Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for milrinone and Hypotension

ArticleYear
What Inotrope and Why?
    Clinics in perinatology, 2020, Volume: 47, Issue:3

    Topics: Cardiac Output; Cardiotonic Agents; Dobutamine; Dopamine; Echocardiography; Epinephrine; Heart; Huma

2020
The Use of Cardiotonic Drugs in Neonates.
    Clinics in perinatology, 2019, Volume: 46, Issue:2

    Topics: Adrenal Cortex Hormones; Asphyxia Neonatorum; Cardiotonic Agents; Dobutamine; Dopamine; Heart Defect

2019
Vasoactive compounds in the neonatal period.
    Current medicinal chemistry, 2012, Volume: 19, Issue:27

    Topics: Adrenal Cortex Hormones; Cardiovascular System; Catecholamines; Humans; Hydrazones; Hypotension; Inf

2012
Diagnosis and treatment of neonatal hypotension outside the transitional period.
    Early human development, 2005, Volume: 81, Issue:5

    Topics: Adrenal Insufficiency; Dobutamine; Dopamine; Ductus Arteriosus, Patent; Humans; Hypotension; Infant,

2005
Diagnosis and treatment of preterm transitional circulatory compromise.
    Early human development, 2005, Volume: 81, Issue:5

    Topics: Adrenal Cortex Hormones; Blood Circulation; Blood Pressure; Cardiac Output, Low; Dobutamine; Dopamin

2005

Trials

4 trials available for milrinone and Hypotension

ArticleYear
The effect of milrinone on induced hypotension in elderly patients during spinal surgery: a randomized controlled trial.
    The spine journal : official journal of the North American Spine Society, 2014, Aug-01, Volume: 14, Issue:8

    Topics: Aged; Blood Loss, Surgical; Double-Blind Method; Elective Surgical Procedures; Female; Hemodynamics;

2014
Comparative hemodynamic effects of vasopressin and norepinephrine after milrinone-induced hypotension in off-pump coronary artery bypass surgical patients.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2006, Volume: 29, Issue:6

    Topics: Aged; Coronary Artery Bypass, Off-Pump; Double-Blind Method; Female; Humans; Hypotension; Intraopera

2006
Safety and clinical utility of long-term intravenous milrinone in advanced heart failure.
    The American journal of cardiology, 1997, Jul-01, Volume: 80, Issue:1

    Topics: Adult; Aged; Cardiotonic Agents; Cohort Studies; Dobutamine; Drug Administration Schedule; Drug Ther

1997
Comparison of the hemodynamic effects of milrinone with dobutamine in patients after cardiac surgery.
    Journal of cardiothoracic and vascular anesthesia, 2001, Volume: 15, Issue:3

    Topics: Adrenergic beta-Agonists; Blood Gas Analysis; Cardiac Output, Low; Cardiac Surgical Procedures; Dobu

2001

Other Studies

25 other studies available for milrinone and Hypotension

ArticleYear
The relationship between simulated milrinone exposure and hypotension in children.
    Cardiology in the young, 2022, Volume: 32, Issue:5

    Topics: Cardiotonic Agents; Child; Hemodynamics; Humans; Hypotension; Milrinone

2022
Inhaled Levosimendan for Pulmonary Hypertension Treatment During Cardiac Surgery: A Novel Application to Avoid Systemic Hypotension.
    Journal of cardiothoracic and vascular anesthesia, 2019, Volume: 33, Issue:4

    Topics: Double-Blind Method; Humans; Hypertension, Pulmonary; Hypotension; Milrinone; Mitral Valve; Pilot Pr

2019
Inhaled Levosimendan for Pulmonary Hypertension Treatment During Cardiac Surgery: A Novel Application to Avoid Systemic Hypotension.
    Journal of cardiothoracic and vascular anesthesia, 2019, Volume: 33, Issue:4

    Topics: Double-Blind Method; Humans; Hypertension, Pulmonary; Hypotension; Milrinone; Mitral Valve; Pilot Pr

2019
Inhaled Levosimendan for Pulmonary Hypertension Treatment During Cardiac Surgery: A Novel Application to Avoid Systemic Hypotension.
    Journal of cardiothoracic and vascular anesthesia, 2019, Volume: 33, Issue:4

    Topics: Double-Blind Method; Humans; Hypertension, Pulmonary; Hypotension; Milrinone; Mitral Valve; Pilot Pr

2019
Inhaled Levosimendan for Pulmonary Hypertension Treatment During Cardiac Surgery: A Novel Application to Avoid Systemic Hypotension.
    Journal of cardiothoracic and vascular anesthesia, 2019, Volume: 33, Issue:4

    Topics: Double-Blind Method; Humans; Hypertension, Pulmonary; Hypotension; Milrinone; Mitral Valve; Pilot Pr

2019
Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2019, Volume: 20, Issue:7

    Topics: Cardiotonic Agents; Ductus Arteriosus, Patent; Echocardiography; Female; Humans; Hypotension; Infant

2019
Myocarditis in fulminant meningococcemia.
    Intensive care medicine, 2019, Volume: 45, Issue:11

    Topics: Adult; Anti-Bacterial Agents; Cardiotonic Agents; Ceftriaxone; Cerebrospinal Fluid; Confusion; Femal

2019
Adrenal function in preterm infants undergoing patent ductus arteriosus ligation.
    Neonatology, 2013, Volume: 104, Issue:1

    Topics: Adrenal Insufficiency; Adrenocorticotropic Hormone; Cardiotonic Agents; Cohort Studies; Ductus Arter

2013
Neonatal circulatory failure due to acute hypertensive crisis: clinical and echocardiographic clues.
    Cardiovascular journal of Africa, 2013, Volume: 24, Issue:3

    Topics: Acute Disease; Antihypertensive Agents; Aortic Valve Insufficiency; Arterial Pressure; Body Weight;

2013
Safety of milrinone use in neonatal intensive care units.
    Early human development, 2015, Volume: 91, Issue:1

    Topics: Cardiotonic Agents; Female; Humans; Hypotension; Infant, Newborn; Infant, Premature; Intensive Care

2015
Use of milrinone in neonatal intensive care medicine.
    Early human development, 2015, Volume: 91, Issue:2

    Topics: Cardiotonic Agents; Female; Humans; Hypotension; Intensive Care Units, Neonatal; Male; Milrinone; Th

2015
Ventricular Rhythm and Hypotension in a Patient with Pheochromocytoma-induced Myocardial Damage and Reverse Takotsubo Cardiomyopathy.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:18

    Topics: Abdominal Pain; Adrenal Gland Neoplasms; Adrenergic beta-Antagonists; Adult; Biomarkers; Cardiac Cat

2015
Dosing of Milrinone in Preterm Neonates to Prevent Postligation Cardiac Syndrome: Simulation Study Suggests Need for Bolus Infusion.
    Neonatology, 2017, Volume: 111, Issue:1

    Topics: Cardiac Output; Cardiotonic Agents; Ductus Arteriosus, Patent; Estonia; Female; Gestational Age; Hum

2017
Management of Neonatal Hypotension.
    Neonatal network : NN, 2017, Jan-01, Volume: 36, Issue:1

    Topics: Blood Pressure; Cardiotonic Agents; Dobutamine; Dopamine; Ductus Arteriosus, Patent; Humans; Hypoten

2017
[Mulibrey syndrome: anesthetic management].
    Revista espanola de anestesiologia y reanimacion, 2010, Volume: 57, Issue:3

    Topics: Abnormalities, Multiple; Anesthesia, Inhalation; Ascites; Child; Comorbidity; Dopamine; Drainage; Fe

2010
Acute renal failure secondary to milrinone in a patient with cardiac amyloidosis.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 40, Issue:2

    Topics: Acute Kidney Injury; Adrenergic beta-Agonists; Amyloidosis; Cardiotonic Agents; Dobutamine; Drug Adm

2002
Concomitant use of nesiritide and milrinone in decompensated congestive heart failure.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2005, Feb-01, Volume: 62, Issue:3

    Topics: Adult; Aged; Blood Pressure; Cardiotonic Agents; Drug Synergism; Drug Therapy, Combination; Female;

2005
The effects of milrinone on hemodynamics in an experimental septic shock model.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2005, Volume: 6, Issue:2

    Topics: Animals; Dilatation, Pathologic; Disease Models, Animal; Female; Hemodynamics; Hypotension; Milrinon

2005
Community-acquired bacterial meningitis.
    The New England journal of medicine, 2006, Mar-30, Volume: 354, Issue:13

    Topics: Catheterization, Swan-Ganz; Community-Acquired Infections; Humans; Hypotension; Meningitis, Bacteria

2006
Is vasopressin really superior to norepinephrine in reversing milrinone-induced vasodilation?
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2006, Volume: 30, Issue:4

    Topics: Coronary Artery Bypass; Humans; Hypotension; Milrinone; Norepinephrine; Vasoconstrictor Agents; Vaso

2006
Arginine vasopressin in advanced cardiovascular failure during the post-resuscitation phase after cardiac arrest.
    Resuscitation, 2007, Volume: 72, Issue:1

    Topics: Aged; Arginine Vasopressin; Bilirubin; Blood Pressure; Epinephrine; Female; Heart Arrest; Humans; Hy

2007
Cardiovascular support in the preterm: treatments in search of indications.
    The Journal of pediatrics, 2007, Volume: 150, Issue:2

    Topics: Cardiac Output, Low; Cardiotonic Agents; Cardiovascular System; Dopamine; Female; Humans; Hypotensio

2007
Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone.
    Pharmacotherapy, 2007, Volume: 27, Issue:5

    Topics: Adrenergic beta-Antagonists; Aged; Arrhythmias, Cardiac; Blood Pressure; Carbazoles; Cardiac Output,

2007
Criteria for use of intravenous milrinone in adult inpatients.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1995, Sep-01, Volume: 52, Issue:17

    Topics: Adult; Arrhythmias, Cardiac; Cardiotonic Agents; Female; Heart Failure; Humans; Hypotension; Infusio

1995
Treatment of milrinone-associated tachycardia with beta-blockers.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:1

    Topics: Adrenergic beta-Antagonists; Aged; Anesthesia, Epidural; Anesthesia, General; Anti-Arrhythmia Agents

1998
Effects of phosphodiesterase inhibitors after coronary artery bypass grafting.
    Japanese circulation journal, 1999, Volume: 63, Issue:2

    Topics: Aged; Cardiotonic Agents; Coronary Artery Bypass; Dobutamine; Dopamine; Female; Hemodynamics; Humans

1999
Vasopressin as an alternative to norepinephrine in the treatment of milrinone-induced hypotension.
    Critical care medicine, 2000, Volume: 28, Issue:1

    Topics: Aged; Aged, 80 and over; Cardiotonic Agents; Coronary Artery Bypass; Fatal Outcome; Female; Heart Va

2000
Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure.
    The American journal of cardiology, 2000, Feb-15, Volume: 85, Issue:4

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Blood Pressure; Cyclic Nucleotide Phosphodiesterases, Type 3; H

2000